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> Protein (NX_Q15672)
Protein (NX_Q15672)
Protein
Gene SymbolTWIST1 to neXtProt (NX_Q15672)
DescriptionTwist-related protein 1
Chromosome7
Location7p21.1 (19060614 ~ 19157295) to Ensembl
Sequene Features : Isoforms 1, Variants 33, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
.cell proliferation involved in heart valve development
.negative regulation of double-strand break repair
  + 51 more...
.E-box binding
.bHLH transcription factor binding
.transcription factor binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 33 0
2014-09-19protein level
1 29 0
2014-05-27protein level
1 29 0
2014-02-25protein level
1 28 0
2013-12-09protein level
1 27 0
2013-11-01protein level
1 27 0
2013-09-12protein level
1 27 0
2013-08-17protein level
1 27 0
2013-07-15protein level
1 20 0
2013-06-11protein level
1 20 0
2013-02-12protein level
1 15 0
2012-12-20protein level
1 15 0
2012-10-30protein level
1 9 0
2012-10-07protein level
1 9 0
2012-08-24protein level
1 9 0
2012-07-28protein level
1 9 0
2012-06-08protein level
1 16 0
2012-05-07protein level
1 16 0
2012-04-10protein level
1 16 0
2012-01-13protein level
1 25 0
2011-12-20protein level
1 25 0
2011-11-11protein level
1 25 0
2011-08-23protein level
1 25 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15672-1
5 0 4 20941.1577
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1797287,EBI-723869 BRD4  
  .negative regulation of DNA damage checkpoint
.regulation of phosphorylation of RNA polymerase II C-terminal domain
.regulation of inflammatory response
  + 15 more...
.lysine-acetylated histone binding
.chromatin binding
.DNA binding
.p53 binding
.positive transcription elongation factor complex b
.cytoplasm
.chromosome
  + 4 more...
2 EBI-1797287,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
3 EBI-1797287,EBI-1646991 ETS2  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.cell differentiation
  + 4 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.nucleoplasm
.nucleus
4 EBI-1797287,EBI-477430 KAT2B  
  .rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 19 more...
.histone deacetylase binding
.protein complex binding
.protein kinase binding
  + 7 more...
.actomyosin
.I band
.A band
  + 5 more...
5 EBI-1797287,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
6 EBI-1797287,EBI-1268946 SETD8  
  .cell division
.negative regulation of transcription, DNA-templated
.regulation of DNA damage response, signal transduction by p53 class mediator
  + 7 more...
.histone-lysine N-methyltransferase activity
.protein-lysine N-methyltransferase activity
.transcription corepressor activity
.p53 binding
.nucleolus
.chromosome
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone55
brain6
ear124
embryonic tissue4
eye4
intestine4
larynx42
ovary9
placenta17
prostate5
skin4
stomach20
uterus25
Health State
TissuesTPM*
normal4
chondrosarcoma24
colorectal tumor8
gastrointestinal tumor16
germ cell tumor3
head and neck tumor7
leukemia21
primitive neuroectodermal tumor of the CNS31
prostate cancer9
skin tumor7
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult1
embryoid body14
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.6
adrenal gland4
appendix1.1
cerebral cortex1.3
esophagus6
gallbladder7.1
heart muscle1.7
lymph node2.3
ovary4.5
placenta15.7
prostate2.4
salivary gland1.1
skin5
testis3.1
urinary bladder5.8
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#101400, phenotype) Saethre-chotzen syndrome; SCSOMIM
2(#123100, phenotype) Craniosynostosis, type 1; CRS1OMIM
3(#180750, phenotype) Robinow-sorauf syndromeOMIM
4(*601622, gene) Twist, drosophila, homolog of, 1; TWIST1OMIM


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