Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q15691)
Protein (NX_Q15691)
Protein
Gene SymbolMAPRE1 to neXtProt (NX_Q15691)
DescriptionMicrotubule-associated protein RP/EB family member 1
Chromosome20
Location20q11.21 (31407699 ~ 31438211) to Ensembl
Sequene Features : Isoforms 1, Variants 23, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of microtubule plus-end binding
.cell division
.protein localization to microtubule
  + 7 more...
.microtubule plus-end binding
.poly(A) RNA binding
.protein C-terminus binding
.microtubule plus-end
.cell projection membrane
.cortical microtubule cytoskeleton
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 23 14
2014-09-19protein level
1 20 14
2014-05-27protein level
1 20 16
2014-02-25protein level
1 20 16
2013-12-09protein level
1 12 16
2013-11-01protein level
1 11 8
2013-09-12protein level
1 11 8
2013-08-17protein level
1 11 8
2013-07-15protein level
1 6 4
2013-06-11protein level
1 6 4
2013-02-12protein level
1 1 5
2012-12-20protein level
1 1 5
2012-10-30protein level
1 4 5
2012-10-07protein level
1 4 5
2012-08-24protein level
1 4 5
2012-07-28protein level
1 4 5
2012-06-08protein level
1 6 5
2012-05-07protein level
1 6 5
2012-04-10protein level
1 6 5
2012-01-13protein level
1 6 5
2011-12-20protein level
1 6 5
2011-11-11protein level
1 6 5
2011-08-23protein level
1 6 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15691-1
12 0 1 29980.1053
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1004115,EBI-713867 PQBP1  
  .regulation of dendrite morphogenesis
.regulation of RNA splicing
.neuron projection development
  + 3 more...
.ribonucleoprotein complex binding
.transcription coactivator activity
.DNA binding
.neuronal ribonucleoprotein granule
.nuclear speck
.cytoplasmic stress granule
  + 3 more...
2 EBI-1004115,EBI-1053045 APC2  
  .negative regulation of canonical Wnt signaling pathway
.negative regulation of catenin import into nucleus
.Wnt signaling pathway
.beta-catenin binding .perinuclear region of cytoplasm
.lamellipodium membrane
.catenin complex
  + 6 more...
3 EBI-1004115,EBI-727707 APC  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.tight junction assembly
  + 47 more...
.microtubule plus-end binding
.gamma-catenin binding
.protein kinase binding
  + 3 more...
.axonal growth cone
.microtubule plus-end
.ruffle membrane
  + 14 more...
4 EBI-1004115,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
5 EBI-1004115,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
6 EBI-1004115,EBI-710997 TERF1  
  .negative regulation of telomerase activity
.cell division
.protein homooligomerization
  + 14 more...
.protein heterodimerization activity
.protein homodimerization activity
.telomeric DNA binding
  + 5 more...
.spindle
.cytoplasm
.nucleolus
  + 5 more...
7 EBI-1004115,EBI-713847 POLE2  
  .error-prone translesion synthesis
.telomere maintenance via semi-conservative replication
.nucleotide-excision repair, DNA gap filling
  + 10 more...
.DNA-directed DNA polymerase activity
.DNA binding
.intracellular membrane-bounded organelle
.epsilon DNA polymerase complex
.nucleoplasm
8 EBI-1004115,EBI-310758 DST  
  .cell motility
.intermediate filament cytoskeleton organization
.hemidesmosome assembly
  + 8 more...
.microtubule plus-end binding
.protein homodimerization activity
.protein C-terminus binding
  + 2 more...
.extracellular exosome
.intermediate filament cytoskeleton
.microtubule plus-end
  + 19 more...
9 EBI-1004115,EBI-2349743 TROAP  
  .cell adhesion .N/A .cytoplasm
10 EBI-1004115,EBI-739717 MAPRE2  
  .cell division
.cell proliferation
.signal transduction
.mitotic nuclear division
.N/A .microtubule plus-end
.microtubule cytoskeleton
.cytoplasm
11 EBI-1004115,EBI-10241662 SPDYE2  
  .regulation of protein kinase activity .protein kinase binding .N/A
12 EBI-1004115,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
13 EBI-1004115,EBI-1105124 PDE4DIP  
  .cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
14 EBI-1004115,EBI-1642317 KIF2C  
  .regulation of chromosome segregation
.cell division
.establishment or maintenance of microtubule cytoskeleton polarity
  + 10 more...
.microtubule plus-end binding
.centromeric DNA binding
.ATPase activity
  + 2 more...
.microtubule plus-end
.membrane
.microtubule cytoskeleton
  + 5 more...
15 EBI-1004115,EBI-726739 MAPRE3  
  .positive regulation of microtubule plus-end binding
.cell division
.positive regulation of transcription, DNA-templated
  + 2 more...
.microtubule binding .perinuclear region of cytoplasm
.microtubule plus-end
.midbody
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland121
ascites175
bladder200
blood179
bone209
bone marrow225
brain181
cervix226
connective tissue127
ear496
embryonic tissue281
esophagus297
eye186
heart55
intestine99
kidney180
larynx42
liver204
lung119
lymph180
lymph node155
mammary gland132
mouth423
muscle37
nerve64
ovary118
pancreas149
parathyroid48
pharynx270
pituitary gland60
placenta130
prostate79
salivary gland246
skin232
spleen112
stomach114
testis174
thymus175
thyroid193
tonsil117
trachea77
umbilical cord508
uterus224
vascular464
Health State
TissuesTPM*
normal169
adrenal tumor79
bladder carcinoma113
breast (mammary gland) tumor128
cervical tumor318
chondrosarcoma205
colorectal tumor62
esophageal tumor347
gastrointestinal tumor118
germ cell tumor277
glioma93
head and neck tumor254
kidney tumor217
leukemia222
liver tumor385
lung tumor126
lymphoma207
non-neoplasia144
ovarian tumor144
pancreatic tumor142
primitive neuroectodermal tumor of the CNS133
prostate cancer115
retinoblastoma430
skin tumor215
soft tissue/muscle tissue tumor175
uterine tumor110
Developmental Stage
TissuesTPM*
adult132
embryoid body300
blastocyst325
neonate386
fetus228
infant85
juvenile557
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue53.8
adrenal gland42.8
appendix67.2
bone marrow108.1
cerebral cortex44.2
colon58
duodenum34.8
esophagus61.4
gallbladder61.1
heart muscle44.1
kidney46.2
liver16.5
lung45.7
lymph node70.3
ovary32.8
pancreas18.4
placenta60.3
prostate48.9
salivary gland23.1
skin29.1
small intestine37.2
spleen50
stomach41.6
testis58.3
thyroid gland74
urinary bladder71.6
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
breastMedium
bronchusMedium
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandLow
placentaMedium
prostateLow
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleLow
spleenMedium
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603108, gene) Microtubule-associated protein, rp/eb family, member 1; MAPRE1OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center