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> Protein (NX_Q15696)
Protein (NX_Q15696)
Protein
Gene SymbolZRSR2 to neXtProt (NX_Q15696)
DescriptionU2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2
ChromosomeX
LocationXp22.2 (15808595 ~ 15841383) to Ensembl
Sequene Features : Isoforms 1, Variants 38, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA splicing
.mRNA splicing, via spliceosome
.spliceosomal complex assembly
.metal ion binding
.pre-mRNA 3'-splice site binding
.nucleotide binding
.U12-type spliceosomal complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 38 2
2014-09-19protein level
1 29 2
2014-05-27protein level
1 29 2
2014-02-25protein level
1 29 2
2013-12-09protein level
1 23 2
2013-11-01protein level
1 23 2
2013-09-12protein level
1 23 2
2013-08-17protein level
1 23 2
2013-07-15protein level
1 14 2
2013-06-11protein level
1 14 2
2013-02-12protein level
1 10 2
2012-12-20protein level
1 9 2
2012-10-30protein level
1 12 2
2012-10-07protein level
1 12 2
2012-08-24protein level
1 12 2
2012-07-28protein level
1 12 2
2012-06-08protein level
1 7 2
2012-05-07protein level
1 7 2
2012-04-10protein level
1 7 2
2012-01-13protein level
1 3 2
2011-12-20protein level
1 3 2
2011-11-11protein level
1 3 2
2011-08-23protein level
1 3 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15696-1
6 0 12 58008.7187
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6657923,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
2 EBI-6657923,EBI-593303 SRPK2  
  .regulation of mRNA splicing, via spliceosome
.positive regulation of cell cycle
.innate immune response
  + 12 more...
.14-3-3 protein binding
.poly(A) RNA binding
.ATP binding
  + 2 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
3 EBI-6657923,EBI-742426 SDCBP2  
  .intracellular transport
.intracellular signal transduction
.nervous system development
.protein heterodimerization activity
.protein homodimerization activity
.protein C-terminus binding
.extracellular exosome
.plasma membrane
.cytoplasm
4 EBI-6657923,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain1
connective tissue20
embryonic tissue4
eye9
intestine4
kidney4
liver58
lung14
lymph node44
mammary gland19
mouth15
ovary9
prostate10
testis4
tonsil117
uterus17
Health State
TissuesTPM*
normal9
breast (mammary gland) tumor21
chondrosarcoma12
colorectal tumor8
germ cell tumor15
head and neck tumor7
lung tumor19
lymphoma13
non-neoplasia10
prostate cancer9
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult6
embryoid body14
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.9
adrenal gland7.1
appendix11
bone marrow13.2
cerebral cortex5.1
colon6.9
duodenum5.7
esophagus5
gallbladder6.5
heart muscle7
kidney7.7
liver3.2
lung10
lymph node13.9
ovary10.8
pancreas1.9
placenta5
prostate7.4
salivary gland5
skin6.2
small intestine4.8
spleen12.8
stomach6.2
testis3
thyroid gland8.6
urinary bladder6.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300028, gene) Zinc finger-, ccch domain-, and rna-binding motif-containing serine/arginine-richOMIM
2myelodysplastic syndrome;chronic lymphatic leukemiaCGP


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