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> Protein (NX_Q15735)
Protein (NX_Q15735)
Protein
Gene SymbolINPP5J to neXtProt (NX_Q15735)
DescriptionPhosphatidylinositol 4,5-bisphosphate 5-phosphatase A
Chromosome22
Location22q12.2 (31518717 ~ 31530682) to Ensembl
Sequene Features : Isoforms 3, Variants 92, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
.inositol phosphate metabolic process
  + 5 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.dendritic shaft
.growth cone
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 92 1
2014-09-19protein level
3 69 1
2014-05-27protein level
3 69 1
2014-02-25protein level
3 69 1
2013-12-09protein level
3 51 1
2013-11-01protein level
3 51 1
2013-09-12protein level
3 51 3
2013-08-17protein level
3 51 3
2013-07-15protein level
3 36 3
2013-06-11protein level
3 36 3
2013-02-12protein level
3 19 3
2012-12-20protein level
3 21 3
2012-10-30protein level
3 22 3
2012-10-07protein level
3 22 3
2012-08-24protein level
3 20 3
2012-07-28protein level
3 20 3
2012-06-08protein level
3 23 3
2012-05-07protein level
3 22 3
2012-04-10protein level
3 22 3
2012-01-13protein level
3 14 3
2011-12-20protein level
3 14 3
2011-11-11protein level
3 14 3
2011-08-23protein level
3 14 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15735-1
10 30 0 107130.0084
NX_Q15735-2
0 27 0 70420.1264
NX_Q15735-3
0 28 0 70195.1537
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10236940,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
2 EBI-10236940,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
3 EBI-10236940,EBI-375576 EPS8  
  .actin polymerization-dependent cell motility
.actin crosslink formation
.actin filament bundle assembly
  + 13 more...
.Rac GTPase binding
.SH3/SH2 adaptor activity
.actin binding
.extracellular exosome
.ruffle membrane
.stereocilium
  + 6 more...
4 EBI-10236940,EBI-3952284 DNAJA3  
  .skeletal muscle acetylcholine-gated channel clustering
.negative regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 23 more...
.chaperone binding
.unfolded protein binding
.NF-kappaB binding
  + 5 more...
.postsynaptic membrane
.intracellular membrane-bounded organelle
.mitochondrial nucleoid
  + 8 more...
5 EBI-10236940,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
6 EBI-10236940,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain53
cervix20
connective tissue6
embryonic tissue14
esophagus49
eye33
heart22
intestine8
kidney23
liver4
lung11
lymph node11
mammary gland19
mouth60
muscle9
pancreas4
parathyroid97
prostate15
spleen37
testis13
thyroid343
trachea57
uterus21
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma12
colorectal tumor8
esophageal tumor57
gastrointestinal tumor8
germ cell tumor18
glioma9
head and neck tumor119
kidney tumor29
liver tumor10
non-neoplasia10
primitive neuroectodermal tumor of the CNS259
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult23
embryoid body14
blastocyst32
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix1
cerebral cortex3.9
colon4.7
duodenum15.5
gallbladder1.2
heart muscle9.5
kidney16.9
lung2.6
pancreas3.8
prostate4.5
salivary gland26.3
skin2.6
small intestine19.7
stomach2.6
testis2.5
thyroid gland127.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*606481, gene) Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, a; PIB5PAOMIM


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