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> Protein (NX_Q15750)
Protein (NX_Q15750)
Protein
Gene SymbolTAB1 to neXtProt (NX_Q15750)
DescriptionTGF-beta-activated kinase 1 and MAP3K7-binding protein 1
Chromosome22
Location22q13.1 (39795746 ~ 39833065) to Ensembl
Sequene Features : Isoforms 2, Variants 64, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 24 more...
.kinase activator activity
.enzyme activator activity
.catalytic activity
.protein complex
.endosome membrane
.cytosol
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 64 6
2014-09-19protein level
2 48 6
2014-05-27protein level
2 48 6
2014-02-25protein level
2 47 6
2013-12-09protein level
2 32 6
2013-11-01protein level
2 32 5
2013-09-12protein level
2 32 5
2013-08-17protein level
2 32 5
2013-07-15protein level
2 26 4
2013-06-11protein level
2 26 4
2013-02-12protein level
2 14 5
2012-12-20protein level
2 11 5
2012-10-30protein level
2 14 5
2012-10-07protein level
2 14 3
2012-08-24protein level
2 14 3
2012-07-28protein level
2 14 3
2012-06-08protein level
2 17 3
2012-05-07protein level
2 17 3
2012-04-10protein level
2 17 3
2012-01-13protein level
2 10 3
2011-12-20protein level
2 10 3
2011-11-11protein level
2 10 3
2011-08-23protein level
1 10 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15750-1
4 21 0 54610.2223
NX_Q15750-2
2 21 0 49886.1196
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-358643,EBI-358684 MAP3K7  
  .negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
2 EBI-358643,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
3 EBI-358643,EBI-73946 MAPK14  
  .positive regulation of reactive oxygen species metabolic process
.positive regulation of myoblast fusion
.regulation of cytokine production involved in inflammatory response
  + 64 more...
.NFAT protein binding
.ATP binding
.MAP kinase kinase activity
  + 2 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 4 more...
4 EBI-358643,EBI-358708 TAB2  
  .nucleotide-binding oligomerization domain containing signaling pathway
.stress-activated MAPK cascade
.positive regulation of NF-kappaB transcription factor activity
  + 23 more...
.K63-linked polyubiquitin binding
.zinc ion binding
.endosome membrane
.plasma membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites50
blood24
bone27
brain88
cervix20
embryonic tissue4
eye23
heart22
intestine4
kidney4
lung11
lymph22
lymph node55
pancreas28
parathyroid48
pituitary gland60
prostate10
testis6
uterus12
Health State
TissuesTPM*
normal57
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma144
colorectal tumor17
gastrointestinal tumor33
germ cell tumor53
glioma55
head and neck tumor74
kidney tumor101
leukemia42
liver tumor83
lung tumor68
lymphoma96
non-neoplasia10
ovarian tumor118
pancreatic tumor9
primitive neuroectodermal tumor of the CNS220
prostate cancer9
retinoblastoma43
skin tumor23
soft tissue/muscle tissue tumor39
Developmental Stage
TissuesTPM*
adult42
embryoid body71
blastocyst81
neonate64
fetus77
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.8
adrenal gland7.7
appendix8.3
bone marrow6.1
cerebral cortex12.4
colon8.2
duodenum9.7
esophagus8.1
gallbladder8
heart muscle9.2
kidney9.3
liver5.3
lung9.9
lymph node10.1
ovary14.9
pancreas4.9
placenta8.3
prostate11.3
salivary gland10.2
skin9.4
small intestine8.5
spleen13.2
stomach9
testis8.8
thyroid gland7.9
urinary bladder9.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602615, gene) Mitogen-activated protein kinase kinase kinase 7-interacting proteinOMIM


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