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> Protein (NX_Q15759)
Protein (NX_Q15759)
Protein
Gene SymbolMAPK11 to neXtProt (NX_Q15759)
DescriptionMitogen-activated protein kinase 11
Chromosome22
Location22q13.33 (50702142 ~ 50709196) to Ensembl
Sequene Features : Isoforms 2, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.stress-activated MAPK cascade
.positive regulation of muscle cell differentiation
.regulation of sequence-specific DNA binding transcription factor activity
  + 25 more...
.ATP binding
.MAP kinase activity
.protein serine/threonine kinase activity
.cytosol
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 37 3
2014-09-19protein level
2 31 3
2014-05-27protein level
1 22 3
2014-02-25protein level
1 22 3
2013-12-09protein level
1 17 3
2013-11-01protein level
1 15 3
2013-09-12protein level
1 15 3
2013-08-17protein level
1 15 3
2013-07-15protein level
1 10 3
2013-06-11protein level
1 10 3
2013-02-12protein level
1 5 3
2012-12-20protein level
1 5 3
2012-10-30protein level
1 5 3
2012-10-07protein level
1 5 3
2012-08-24protein level
1 5 3
2012-07-28protein level
1 5 3
2012-06-08protein level
1 9 3
2012-05-07protein level
1 7 3
2012-04-10protein level
1 7 3
2012-01-13protein level
1 8 3
2011-12-20protein level
1 8 2
2011-11-11protein level
1 8 2
2011-08-23protein level
1 8 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15759-1
12 4 1 41331.0255
NX_Q15759-3
5 4 1 23587.5893
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-298304,EBI-347522 ZNHIT1  
  .negative regulation of G0 to G1 transition
.histone exchange
.regulation of T cell proliferation
  + 2 more...
.metal ion binding
.histone deacetylase binding
.nucleosome binding
.nucleus
.Swr1 complex
2 EBI-298304,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
blood73
brain18
intestine12
liver24
mammary gland19
nerve64
ovary9
placenta14
prostate10
skin28
spleen18
stomach10
thyroid42
vascular19
Health State
TissuesTPM*
normal12
colorectal tumor17
gastrointestinal tumor16
germ cell tumor3
glioma18
head and neck tumor14
leukemia84
primitive neuroectodermal tumor of the CNS70
prostate cancer9
skin tumor47
Developmental Stage
TissuesTPM*
adult12
fetus30
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18.1
adrenal gland5.1
appendix7.7
cerebral cortex15.2
colon2.7
duodenum1.8
esophagus5
gallbladder8.5
heart muscle6.7
kidney4.5
lung11.9
lymph node9.2
ovary4.6
pancreas1.4
placenta6
prostate8
salivary gland4.3
skin5.3
small intestine2.3
spleen8.2
stomach4
testis4.5
thyroid gland4.4
urinary bladder6.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602898, gene) Mitogen-activated protein kinase 11; MAPK11OMIM


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