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> Protein (NX_Q15796)
Protein (NX_Q15796)
Protein
Gene SymbolSMAD2 to neXtProt (NX_Q15796)
DescriptionMothers against decapentaplegic homolog 2
Chromosome18
Location18q21.1 (45357922 ~ 45457515) to Ensembl
Sequene Features : Isoforms 2, Variants 62, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.response to cholesterol
.SMAD protein signal transduction
  + 42 more...
.R-SMAD binding
.I-SMAD binding
.co-SMAD binding
  + 15 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.activin responsive factor complex
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 62 13
2014-09-19protein level
2 50 13
2014-05-27protein level
2 50 13
2014-02-25protein level
2 50 13
2013-12-09protein level
2 49 13
2013-11-01protein level
2 49 13
2013-09-12protein level
2 49 13
2013-08-17protein level
2 49 13
2013-07-15protein level
2 38 13
2013-06-11protein level
2 38 13
2013-02-12protein level
2 16 24
2012-12-20protein level
2 16 24
2012-10-30protein level
2 16 24
2012-10-07protein level
2 16 12
2012-08-24protein level
2 6 12
2012-07-28protein level
2 6 12
2012-06-08protein level
2 18 12
2012-05-07protein level
2 22 12
2012-04-10protein level
2 22 12
2012-01-13protein level
2 20 12
2011-12-20protein level
2 20 12
2011-11-11protein level
2 20 13
2011-08-23protein level
2 19 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q15796-1
1 9 9 52272.6209
NX_Q15796-2
0 9 9 48924.1527
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1040141,EBI-743923 WWP2  
  .regulation of potassium ion transmembrane transporter activity
.protein K63-linked ubiquitination
.protein autoubiquitination
  + 13 more...
.ligase activity
.transcription factor binding
.ubiquitin-protein transferase activity
.RNA polymerase II transcription factor binding
.extracellular exosome
.membrane
.cytoplasm
  + 2 more...
2 EBI-1040141,EBI-296817 ZFYVE9  
  .negative regulation of transforming growth factor beta receptor signaling pathway
.SMAD protein import into nucleus
.SMAD protein complex assembly
  + 3 more...
.metal ion binding
.serine-type peptidase activity
.1-phosphatidylinositol binding
.early endosome membrane
.early endosome
3 EBI-1040141,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
4 EBI-1040141,EBI-712619 CHGB  
  .N/A .hormone activity .secretory granule
.extracellular region
5 EBI-1040141,EBI-1105035 NEFM  
  .activation of mitophagy in response to mitochondrial depolarization
.neurofilament bundle assembly
.regulation of axon diameter
  + 2 more...
.microtubule binding
.structural constituent of cytoskeleton
.neurofibrillary tangle
.neuromuscular junction
.axon
.neurofilament
6 EBI-1040141,EBI-989143 PPM1A  
  .positive regulation of transcription, DNA-templated
.negative regulation of I-kappaB kinase/NF-kappaB signaling
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 16 more...
.R-SMAD binding
.calmodulin-dependent protein phosphatase activity
.manganese ion binding
  + 3 more...
.neuron projection
.membrane
.voltage-gated calcium channel complex
  + 3 more...
7 EBI-1040141,EBI-446668 RHOA  
  .skeletal muscle satellite cell migration
.mitotic spindle assembly
.trabecula morphogenesis
  + 32 more...
.myosin binding
.GTP binding
.GTPase activity
.extracellular exosome
.apical junction complex
.cleavage furrow
  + 11 more...
8 EBI-1040141,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
9 EBI-1040141,EBI-1171238 DAB2  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of integrin-mediated signaling pathway
.positive regulation of early endosome to late endosome transport
  + 35 more...
.SMAD binding
.cargo receptor activity
.clathrin adaptor activity
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
  + 8 more...
10 EBI-1040141,EBI-2691178 ANK3  
  .positive regulation of sodium ion transmembrane transporter activity
.negative regulation of delayed rectifier potassium channel activity
.positive regulation of membrane depolarization during cardiac muscle cell action potential
  + 23 more...
.cadherin binding
.ion channel binding
.protein binding, bridging
  + 3 more...
.postsynaptic membrane
.axon initial segment
.costamere
  + 17 more...
11 EBI-1040141,EBI-347263 SMAD4  
  .nephrogenic mesenchyme morphogenesis
.metanephric mesenchyme morphogenesis
.response to transforming growth factor beta
  + 49 more...
.R-SMAD binding
.I-SMAD binding
.metal ion binding
  + 9 more...
.SMAD protein complex
.activin responsive factor complex
.cytosol
  + 6 more...
12 EBI-1040141,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
13 EBI-1040141,EBI-3867416 OLIG1  
  .neuron fate commitment
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .nucleus
14 EBI-1040141,EBI-2513582 ZFR  
  .multicellular organismal development .poly(A) RNA binding
.zinc ion binding
.DNA binding
.cytoplasm
.chromosome
.nucleoplasm
15 EBI-1040141,EBI-2695893 DOCK9  
  .blood coagulation
.small GTPase mediated signal transduction
.Rho guanyl-nucleotide exchange factor activity .membrane
.endomembrane system
.cytosol
16 EBI-1040141,EBI-2337775 TP63  
  .positive regulation of apoptotic signaling pathway
.negative regulation of cellular senescence
.negative regulation of mesoderm development
  + 54 more...
.WW domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 10 more...
.dendrite
.cytosol
.rough endoplasmic reticulum
  + 6 more...
17 EBI-1040141,EBI-992681 RANBP3  
  .intracellular transport
.protein transport
.R-SMAD binding
.Ran GTPase binding
.cytoplasm
.nucleoplasm
.nucleus
18 EBI-1040141,EBI-396727 SMURF2  
  .positive regulation of trophoblast cell migration
.positive regulation of canonical Wnt signaling pathway
.negative regulation of transcription, DNA-templated
  + 11 more...
.ubiquitin protein ligase activity
.SMAD binding
.identical protein binding
  + 2 more...
.membrane raft
.plasma membrane
.cytosol
  + 4 more...
19 EBI-1040141,EBI-1052346 MTMR4  
  .small molecule metabolic process
.peptidyl-tyrosine dephosphorylation
.negative regulation of transforming growth factor beta receptor signaling pathway
  + 5 more...
.metal ion binding
.protein tyrosine phosphatase activity
.protein serine/threonine phosphatase activity
.early endosome membrane
.cytosol
.extracellular space
20 EBI-1040141,EBI-2214398 TRIM33  
  .negative regulation of transcription, DNA-templated
.negative regulation of BMP signaling pathway
.regulation of transforming growth factor beta receptor signaling pathway
  + 6 more...
.R-SMAD binding
.co-SMAD binding
.ligase activity
  + 3 more...
.intracellular membrane-bounded organelle
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites50
bladder167
blood179
bone41
bone marrow20
brain48
cervix247
connective tissue33
ear124
embryonic tissue51
eye52
heart67
intestine68
kidney75
larynx255
liver58
lung50
lymph22
lymph node155
mammary gland52
mouth75
muscle9
ovary9
pancreas14
parathyroid48
placenta24
spleen18
stomach31
testis9
thyroid42
Health State
TissuesTPM*
normal66
adrenal tumor158
bladder carcinoma170
breast (mammary gland) tumor21
cervical tumor289
chondrosarcoma60
colorectal tumor71
gastrointestinal tumor42
germ cell tumor45
glioma83
head and neck tumor74
kidney tumor101
leukemia201
liver tumor72
lung tumor29
lymphoma69
non-neoplasia51
ovarian tumor65
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer77
retinoblastoma21
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor66
Developmental Stage
TissuesTPM*
adult71
embryoid body42
blastocyst65
neonate32
fetus89
infant85
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue40.6
adrenal gland52.8
appendix39
bone marrow21.3
cerebral cortex31.4
colon46.3
duodenum32.9
esophagus52.3
gallbladder40.9
heart muscle42.6
kidney37.3
liver19.9
lung41.5
lymph node43.1
ovary49.3
pancreas17.9
placenta43.7
prostate32.7
salivary gland28.8
skin26.9
small intestine33.7
spleen41.4
stomach42.2
testis50
thyroid gland75.6
urinary bladder57.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601366, gene) Mothers against decapentaplegic, drosophila, homolog of, 2; SMAD2OMIM


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