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> Protein (NX_Q16186)
Protein (NX_Q16186)
Protein
Gene SymbolADRM1 to neXtProt (NX_Q16186)
DescriptionProteasomal ubiquitin receptor ADRM1
Chromosome20
Location20q13.33 (60877149 ~ 60883918) to Ensembl
Sequene Features : Isoforms 1, Variants 41, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.proteasome assembly
.positive regulation of endopeptidase activity
.transcription elongation from RNA polymerase II promoter
.proteasome binding
.endopeptidase activator activity
.protease binding
.membrane
.integral component of plasma membrane
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 41 9
2014-09-19protein level
1 32 9
2014-05-27protein level
1 32 9
2014-02-25protein level
1 31 9
2013-12-09protein level
1 22 9
2013-11-01protein level
1 21 8
2013-09-12protein level
1 21 9
2013-08-17protein level
1 21 9
2013-07-15protein level
1 15 7
2013-06-11protein level
1 15 7
2013-02-12protein level
1 9 10
2012-12-20protein level
1 9 10
2012-10-30protein level
1 9 10
2012-10-07protein level
1 9 10
2012-08-24protein level
1 9 10
2012-07-28protein level
1 9 10
2012-06-08protein level
1 10 10
2012-05-07protein level
1 9 10
2012-04-10protein level
1 9 10
2012-01-13protein level
1 11 10
2011-12-20protein level
1 11 10
2011-11-11protein level
1 11 9
2011-08-23protein level
1 11 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16186-1
14 0 0 42126.6925
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-954387,EBI-3390054 UBC  
  .programmed necrotic cell death
.apoptotic signaling pathway
.energy homeostasis
  + 90 more...
.poly(A) RNA binding
.protease binding
.extracellular exosome
.endocytic vesicle membrane
.endosome membrane
  + 3 more...
2 EBI-954387,EBI-954531 RAD23B  
  .proteasome-mediated ubiquitin-dependent protein catabolic process
.regulation of proteasomal ubiquitin-dependent protein catabolic process
.spermatogenesis
  + 4 more...
.polyubiquitin binding
.single-stranded DNA binding
.damaged DNA binding
.XPC complex
.cytoplasm
.nucleoplasm
  + 2 more...
3 EBI-954387,EBI-359318 PSMD4  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 21 more...
.poly(A) RNA binding
.identical protein binding
.proteasome accessory complex
.proteasome regulatory particle, base subcomplex
.cytosol
  + 3 more...
4 EBI-954387,EBI-947187 UBQLN2  
  .regulation of autophagic vacuole assembly
.negative regulation of G-protein coupled receptor internalization
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
  + 2 more...
.N/A .plasma membrane
.cytoplasm
.nucleus
5 EBI-954387,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
6 EBI-954387,EBI-1051183 UCHL5  
  .regulation of proteasomal protein catabolic process
.forebrain morphogenesis
.midbrain development
  + 10 more...
.proteasome binding
.poly(A) RNA binding
.omega peptidase activity
  + 2 more...
.Ino80 complex
.cytosol
.nucleus
.proteasome complex
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites150
bladder33
blood106
bone83
bone marrow102
brain85
cervix247
connective tissue53
embryonic tissue112
eye162
intestine172
kidney80
liver102
lung200
lymph135
lymph node66
mammary gland224
mouth15
muscle94
nerve128
ovary325
pancreas121
pharynx73
placenta155
prostate94
salivary gland98
skin910
spleen131
stomach31
testis193
thymus50
thyroid85
tonsil176
trachea19
umbilical cord145
uterus103
vascular38
Health State
TissuesTPM*
normal123
adrenal tumor158
bladder carcinoma56
breast (mammary gland) tumor290
cervical tumor231
chondrosarcoma169
colorectal tumor266
gastrointestinal tumor101
germ cell tumor125
glioma121
head and neck tumor59
kidney tumor174
leukemia84
liver tumor124
lung tumor369
lymphoma152
non-neoplasia41
ovarian tumor393
pancreatic tumor209
primitive neuroectodermal tumor of the CNS220
prostate cancer154
retinoblastoma150
skin tumor374
soft tissue/muscle tissue tumor87
uterine tumor155
Developmental Stage
TissuesTPM*
adult146
embryoid body114
blastocyst130
neonate96
fetus26
infant127
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue46.2
adrenal gland37.1
appendix47.9
bone marrow39.5
cerebral cortex31.7
colon36
duodenum43.8
esophagus37.1
gallbladder35.2
heart muscle40.1
kidney39.8
liver35.8
lung34.8
lymph node48.3
ovary19.7
pancreas37.3
placenta42
prostate42.5
salivary gland33.4
skin39.6
small intestine35.8
spleen52.2
stomach46.2
testis85.3
thyroid gland26.2
urinary bladder34
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderHigh
hippocampusMedium
kidneyHigh
lateral ventricleHigh
liverMedium
lungLow
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandHigh
skeletal muscleMedium
skin 1Medium
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610650, gene) Adhesion-regulating molecule 1; ADRM1OMIM


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