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> Protein (NX_Q16363)
Protein (NX_Q16363)
Protein
Gene SymbolLAMA4 to neXtProt (NX_Q16363)
DescriptionLaminin subunit alpha-4
Chromosome6
Location6q21 (112429963 ~ 112576141) to Ensembl
Sequene Features : Isoforms 3, Variants 262, PTMs 38 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of embryonic development
.regulation of cell migration
.extracellular matrix organization
  + 2 more...
.extracellular matrix structural constituent .extracellular exosome
.laminin-1 complex
.basal lamina
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 262 38
2014-09-19protein level
3 209 38
2014-05-27protein level
3 209 38
2014-02-25protein level
3 207 38
2013-12-09protein level
3 160 38
2013-11-01protein level
3 155 38
2013-09-12protein level
3 155 38
2013-08-17protein level
3 154 38
2013-07-15protein level
3 111 38
2013-06-11protein level
3 111 38
2013-02-12protein level
3 52 78
2012-12-20protein level
3 50 78
2012-10-30protein level
3 70 78
2012-10-07protein level
3 70 39
2012-08-24protein level
3 54 39
2012-07-28protein level
3 54 39
2012-06-08protein level
3 58 39
2012-05-07protein level
3 58 39
2012-04-10protein level
3 58 39
2012-01-13protein level
3 29 39
2011-12-20protein level
3 29 39
2011-11-11protein level
3 29 39
2011-08-23protein level
3 29 39
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16363-1
1 78 0 202396.0635
NX_Q16363-2
1 78 0 201648.7722
NX_Q16363-3
2 4 0 12810.3351
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-711505,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue777
adrenal gland30
bone111
bone marrow41
brain53
cervix20
connective tissue194
embryonic tissue37
eye114
heart256
intestine185
kidney61
liver4
lung95
mammary gland59
mouth90
muscle206
nerve64
ovary9
pancreas9
parathyroid48
placenta81
prostate47
skin94
spleen18
stomach94
testis29
thymus12
thyroid107
trachea193
umbilical cord435
uterus133
vascular387
Health State
TissuesTPM*
normal93
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor75
cervical tumor28
chondrosarcoma193
colorectal tumor248
gastrointestinal tumor50
germ cell tumor37
glioma102
head and neck tumor82
kidney tumor43
liver tumor10
lung tumor29
lymphoma13
non-neoplasia93
ovarian tumor26
pancreatic tumor19
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor71
uterine tumor99
Developmental Stage
TissuesTPM*
adult96
embryoid body14
blastocyst48
neonate225
fetus152
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue90.3
adrenal gland8.6
appendix30.5
cerebral cortex5
colon30.4
duodenum14.8
esophagus32.2
gallbladder39.8
heart muscle25
kidney4.4
liver3.6
lung44.5
lymph node10.7
ovary10.8
pancreas2.2
placenta38.9
prostate22.9
salivary gland25.1
skin9.9
small intestine17.7
spleen1.1
stomach15.4
testis14.4
thyroid gland14.9
urinary bladder41.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600133, gene) Laminin, alpha-4; LAMA4OMIM


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