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> Protein (NX_Q16401)
Protein (NX_Q16401)
Protein
Gene SymbolPSMD5 to neXtProt (NX_Q16401)
Description26S proteasome non-ATPase regulatory subunit 5
Chromosome9
Location9q33.2 (123577774 ~ 123605262) to Ensembl
Sequene Features : Isoforms 2, Variants 45, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.proteasome regulatory particle assembly
  + 22 more...
.N/A .proteasome accessory complex
.cytosol
.nucleoplasm
.proteasome complex
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 45 4
2014-09-19protein level
2 34 4
2014-05-27protein level
2 34 4
2014-02-25protein level
2 34 4
2013-12-09protein level
2 25 4
2013-11-01protein level
2 24 3
2013-09-12protein level
2 24 3
2013-08-17protein level
2 24 3
2013-07-15protein level
2 14 1
2013-06-11protein level
2 14 1
2013-02-12protein level
2 10 1
2012-12-20protein level
1 9 1
2012-10-30protein level
1 17 1
2012-10-07protein level
1 17 1
2012-08-24protein level
1 15 1
2012-07-28protein level
1 15 1
2012-06-08protein level
1 15 1
2012-05-07protein level
1 15 1
2012-04-10protein level
1 15 1
2012-01-13protein level
1 7 1
2011-12-20protein level
1 7 1
2011-11-11protein level
1 7 1
2011-08-23protein level
1 7 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16401-1
2 22 0 56160.1981
NX_Q16401-2
1 22 0 51279.6013
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-752143,EBI-359710 PSMC2  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 26 more...
.proteasome-activating ATPase activity
.TBP-class protein binding
.ATPase activity
.ATP binding
.cytosolic proteasome complex
.nuclear proteasome complex
.proteasome accessory complex
  + 8 more...
2 EBI-752143,EBI-357598 PSMC1  
  .positive regulation of proteasomal protein catabolic process
.positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
  + 24 more...
.poly(A) RNA binding
.proteasome-activating ATPase activity
.TBP-class protein binding
  + 2 more...
.cytosolic proteasome complex
.nuclear proteasome complex
.cell junction
  + 8 more...
3 EBI-752143,EBI-717422 TFCP2  
  .regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.protein C-terminus binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites25
bladder33
blood24
bone69
bone marrow20
brain36
cervix20
connective tissue26
embryonic tissue56
esophagus49
eye9
heart67
intestine38
kidney18
liver73
lung20
lymph node11
mammary gland26
mouth60
muscle18
ovary9
pancreas9
pharynx24
placenta52
prostate15
skin71
spleen37
stomach31
testis96
thymus37
thyroid85
trachea19
uterus43
vascular96
Health State
TissuesTPM*
normal40
adrenal tumor79
breast (mammary gland) tumor42
cervical tumor28
colorectal tumor35
esophageal tumor57
gastrointestinal tumor16
germ cell tumor60
glioma9
head and neck tumor44
kidney tumor14
leukemia31
liver tumor83
lung tumor9
lymphoma27
non-neoplasia41
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor63
uterine tumor22
Developmental Stage
TissuesTPM*
adult33
embryoid body57
blastocyst65
neonate32
fetus50
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.1
adrenal gland18.2
appendix14.8
bone marrow15.2
cerebral cortex9
colon14.7
duodenum11.6
esophagus17.2
gallbladder13.8
heart muscle7.5
kidney12
liver8.9
lung13.9
lymph node15.8
ovary15.4
pancreas6.9
placenta11.1
prostate17.1
salivary gland13.1
skin16.3
small intestine12.2
spleen11.2
stomach13.3
testis14.5
thyroid gland14.6
urinary bladder21
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604452, gene) Proteasome 26s subunit, non-atpase, 5; PSMD5OMIM


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