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> Protein (NX_Q16512)
Protein (NX_Q16512)
Protein
Gene SymbolPKN1 to neXtProt (NX_Q16512)
DescriptionSerine/threonine-protein kinase N1
Chromosome19
Location19p13.12 (14543865 ~ 14582679) to Ensembl
Sequene Features : Isoforms 3, Variants 104, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell motility
.histone H3-T11 phosphorylation
.epithelial cell migration
  + 7 more...
.androgen receptor binding
.Rac GTPase binding
.histone deacetylase binding
  + 10 more...
.cleavage furrow
.midbody
.cytoplasmic membrane-bounded vesicle
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 104 17
2014-09-19protein level
3 80 17
2014-05-27protein level
3 80 17
2014-02-25protein level
3 79 16
2013-12-09protein level
3 54 16
2013-11-01protein level
3 54 15
2013-09-12protein level
3 54 15
2013-08-17protein level
3 54 16
2013-07-15protein level
3 36 14
2013-06-11protein level
3 36 14
2013-02-12protein level
3 19 40
2012-12-20protein level
3 17 39
2012-10-30protein level
3 24 40
2012-10-07protein level
3 24 15
2012-08-24protein level
3 24 15
2012-07-28protein level
3 24 15
2012-06-08protein level
3 24 15
2012-05-07protein level
3 24 15
2012-04-10protein level
3 24 15
2012-01-13protein level
3 24 15
2011-12-20protein level
3 31 15
2011-11-11protein level
3 31 15
2011-08-23protein level
3 31 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16512-1
0 36 2 103867.2584
NX_Q16512-2
1 35 2 104607.5542
NX_Q16512-3
1 22 0 66019.2255
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-602382,EBI-2340316 MID1  
  .interferon-gamma-mediated signaling pathway
.protein localization to microtubule
.positive regulation of stress-activated MAPK cascade
  + 4 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.microtubule associated complex
.microtubule
.cytosol
.spindle
2 EBI-602382,EBI-353844 VIM  
  .lens fiber cell development
.SMAD protein signal transduction
.Bergmann glial cell differentiation
  + 10 more...
.keratin filament binding
.scaffold protein binding
.identical protein binding
  + 5 more...
.extracellular exosome
.intermediate filament cytoskeleton
.neuron projection
  + 8 more...
3 EBI-602382,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-602382,EBI-602406 MAPK12  
  .positive regulation of muscle cell differentiation
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 14 more...
.ATP binding
.MAP kinase activity
.protein serine/threonine kinase activity
.magnesium ion binding
.cytosol
.mitochondrion
.cytoplasm
.nucleoplasm
5 EBI-602382,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
6 EBI-602382,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
7 EBI-602382,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
8 EBI-602382,EBI-739674 CCDC85B  
  .negative regulation of transcription, DNA-templated
.negative regulation of fat cell differentiation
.negative regulation of cell growth
  + 2 more...
.N/A .centrosome
.cytoplasm
.nucleus
9 EBI-602382,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
10 EBI-602382,EBI-687346 ZAK  
  .positive regulation of apoptotic process
.intracellular signal transduction
.cell differentiation
  + 11 more...
.poly(A) RNA binding
.ATP binding
.MAP kinase kinase kinase activity
  + 2 more...
.cytoplasm
.nucleus
11 EBI-602382,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites150
blood147
bone167
bone marrow61
brain68
cervix82
connective tissue60
embryonic tissue42
esophagus99
eye138
heart33
intestine81
kidney94
liver43
lung119
lymph812
lymph node66
mammary gland85
mouth30
muscle56
nerve128
ovary78
pancreas84
placenta45
prostate94
salivary gland345
skin118
spleen93
stomach94
testis94
thymus200
thyroid128
tonsil411
trachea19
umbilical cord145
uterus103
vascular38
Health State
TissuesTPM*
normal66
adrenal tumor158
breast (mammary gland) tumor53
cervical tumor115
chondrosarcoma181
colorectal tumor88
esophageal tumor115
gastrointestinal tumor177
germ cell tumor72
glioma186
head and neck tumor67
kidney tumor203
leukemia84
liver tumor83
lung tumor214
lymphoma623
non-neoplasia82
ovarian tumor39
pancreatic tumor142
primitive neuroectodermal tumor of the CNS181
prostate cancer77
retinoblastoma193
skin tumor159
soft tissue/muscle tissue tumor167
uterine tumor55
Developmental Stage
TissuesTPM*
adult88
embryoid body28
blastocyst65
neonate64
fetus73
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue39.1
adrenal gland27.1
appendix40.7
bone marrow42.6
cerebral cortex24.1
colon18.5
duodenum11.5
esophagus16.3
gallbladder26.5
heart muscle44.7
kidney25.6
liver10
lung47.1
lymph node50.5
ovary23.7
pancreas21.9
placenta31.5
prostate28.4
salivary gland27.2
skin7.7
small intestine16.3
spleen65.6
stomach34.7
testis42.3
thyroid gland29.6
urinary bladder29.2
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastLow
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisHigh
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusLow
kidneyHigh
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*601032, gene) Protein kinase n1; PKN1OMIM


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