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> Protein (NX_Q16543)
Protein (NX_Q16543)
Protein
Gene SymbolCDC37 to neXtProt (NX_Q16543)
DescriptionHsp90 co-chaperone Cdc37
Chromosome19
Location19p13.2 (10501810 ~ 10530797) to Ensembl
Sequene Features : Isoforms 1, Variants 54, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 54 9
2014-09-19protein level
1 38 9
2014-05-27protein level
1 38 9
2014-02-25protein level
1 38 9
2013-12-09protein level
1 33 9
2013-11-01protein level
1 31 6
2013-09-12protein level
1 31 6
2013-08-17protein level
1 31 6
2013-07-15protein level
1 20 5
2013-06-11protein level
1 20 5
2013-02-12protein level
1 10 9
2012-12-20protein level
1 10 9
2012-10-30protein level
1 11 9
2012-10-07protein level
1 11 9
2012-08-24protein level
1 8 9
2012-07-28protein level
1 8 9
2012-06-08protein level
1 8 9
2012-05-07protein level
1 8 9
2012-04-10protein level
1 8 9
2012-01-13protein level
1 5 9
2011-12-20protein level
1 5 9
2011-11-11protein level
1 5 9
2011-08-23protein level
1 5 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16543-1
13 0 0 44439.8742
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-295634,EBI-745127 IFIT3  
  .type I interferon signaling pathway
.defense response to virus
.negative regulation of apoptotic process
  + 4 more...
.identical protein binding .cytosol
.mitochondrion
.cytoplasm
2 EBI-295634,EBI-81266 IKBKB  
  .positive regulation of cation channel activity
.cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
  + 32 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
3 EBI-295634,EBI-81249 CHUK  
  .cellular response to tumor necrosis factor
.nucleotide-binding oligomerization domain containing signaling pathway
.mammary gland alveolus development
  + 45 more...
.scaffold protein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.intracellular membrane-bounded organelle
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
4 EBI-295634,EBI-358700 MAP3K7  
  .negative regulation of apoptotic signaling pathway
.regulation of reactive oxygen species metabolic process
.negative regulation of ripoptosome assembly involved in necroptotic process
  + 37 more...
.scaffold protein binding
.ATP binding
.MAP kinase kinase kinase activity
  + 4 more...
.endosome membrane
.plasma membrane
.cytosol
  + 4 more...
5 EBI-295634,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
6 EBI-295634,EBI-1222467 APOE  
  .positive regulation of lipid transport across blood brain barrier
.negative regulation of lipid transport across blood brain barrier
.negative regulation of phospholipid efflux
  + 90 more...
.lipoprotein particle binding
.very-low-density lipoprotein particle receptor binding
.phosphatidylcholine-sterol O-acyltransferase activator activity
  + 14 more...
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 24 more...
7 EBI-295634,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
8 EBI-295634,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
9 EBI-295634,EBI-296047 HSP90AA1  
  .regulation of cellular response to heat
.positive regulation of cardiac muscle contraction
.chaperone-mediated protein complex assembly
  + 26 more...
.GTPase binding
.poly(A) RNA binding
.protein homodimerization activity
  + 12 more...
.endocytic vesicle lumen
.extracellular exosome
.perinuclear region of cytoplasm
  + 17 more...
10 EBI-295634,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
11 EBI-295634,EBI-295644 CDK4  
  .negative regulation of cell cycle arrest
.response to hyperoxia
.cell division
  + 20 more...
.cyclin binding
.cyclin-dependent protein serine/threonine kinase regulator activity
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.nuclear membrane
.tight junction
  + 7 more...
12 EBI-295634,EBI-1380661 FER  
  .interleukin-6-mediated signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.diapedesis
  + 37 more...
.lipid binding
.ATP binding
.epidermal growth factor receptor binding
  + 2 more...
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.cell junction
  + 5 more...
13 EBI-295634,EBI-1391623 NOS3  
  .negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.phagosome maturation
.negative regulation of calcium ion transport
  + 34 more...
.NADP binding
.flavin adenine dinucleotide binding
.cadmium ion binding
  + 8 more...
.endocytic vesicle membrane
.caveola
.plasma membrane
  + 5 more...
14 EBI-295634,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
15 EBI-295634,EBI-297277 PSEN1  
  .negative regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.calcium ion transmembrane transport
  + 65 more...
.cadherin binding
.PDZ domain binding
.beta-catenin binding
  + 3 more...
.gamma-secretase complex
.perinuclear region of cytoplasm
.membrane raft
  + 29 more...
16 EBI-295634,EBI-1383449 CDK9  
  .positive regulation of histone H2B ubiquitination
.positive regulation of mRNA 3'-UTR binding
.negative regulation of mRNA polyadenylation
  + 18 more...
.transcription regulatory region DNA binding
.snRNA binding
.RNA polymerase II carboxy-terminal domain kinase activity
  + 5 more...
.intracellular membrane-bounded organelle
.PML body
.membrane
  + 4 more...
17 EBI-295634,EBI-716663 PPP5C  
  .protein heterooligomerization
.response to morphine
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 5 more...
.metal ion binding
.identical protein binding
.lipid binding
  + 4 more...
.intracellular membrane-bounded organelle
.neuronal cell body
.neuron projection
  + 5 more...
18 EBI-295634,EBI-295663 CDK6  
  .negative regulation of cellular senescence
.regulation of cell motility
.hematopoietic stem cell differentiation
  + 26 more...
.cyclin binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.cytosol
.centrosome
.cytoplasm
  + 4 more...
19 EBI-295634,EBI-1047444 FKBP4  
  .regulation of cellular response to heat
.chaperone-mediated protein folding
.male sex differentiation
  + 12 more...
.poly(A) RNA binding
.heat shock protein binding
.protein binding, bridging
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.axonal growth cone
  + 7 more...
20 EBI-295634,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
21 EBI-295634,EBI-456067 CUL4B  
  .positive regulation of G1/S transition of mitotic cell cycle
.UV-damage excision repair
.positive regulation of protein catabolic process
  + 6 more...
.N/A .extracellular exosome
.Cul4B-RING E3 ubiquitin ligase complex
.plasma membrane
  + 2 more...
22 EBI-295634,EBI-307369 IKBKE  
  .innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
.NIK/NF-kappaB signaling
  + 9 more...
.IkappaB kinase activity
.ATP binding
.NF-kappaB-inducing kinase activity
.mitochondrial membrane
.PML body
.endosome membrane
  + 4 more...
23 EBI-295634,EBI-306838 STK11  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.cellular response to UV-B
.negative regulation of epithelial cell proliferation involved in prostate gland development
  + 35 more...
.protein kinase activator activity
.ATP binding
.protein serine/threonine kinase activity
  + 2 more...
.extracellular exosome
.TCR signalosome
.membrane
  + 4 more...
24 EBI-295634,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
25 EBI-295634,EBI-6428016 ZNF843  
  .N/A .metal ion binding
.nucleic acid binding
.N/A
26 EBI-295634,EBI-624291 AURKB  
  .regulation of chromosome segregation
.mitotic spindle midzone assembly
.protein autophosphorylation
  + 20 more...
.metal ion binding
.histone serine kinase activity
.ATP binding
  + 2 more...
.spindle midzone
.chromosome passenger complex
.spindle pole centrosome
  + 8 more...
27 EBI-295634,EBI-1051975 CDK15  
  .N/A .metal ion binding
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein serine/threonine kinase activity
.N/A
28 EBI-295634,EBI-358011 MAP3K14  
  .cellular response to mechanical stimulus
.innate immune response
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 9 more...
.ATP binding
.MAP kinase kinase kinase activity
.MAP kinase kinase activity
  + 3 more...
.cytosol
.cytoplasm
29 EBI-295634,EBI-914727 FBXW2  
  .protein ubiquitination
.proteolysis
.cellular protein modification process
.ubiquitin-protein transferase activity .cytoplasm
30 EBI-295634,EBI-296115 AKT3  
  .signal transduction
.protein phosphorylation
.mitochondrial genome maintenance
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.plasma membrane
.Golgi apparatus
.cytoplasm
.nucleoplasm
31 EBI-295634,EBI-991501 STK38L  
  .regulation of cellular component organization
.intracellular signal transduction
.protein phosphorylation
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.membrane
.actin cytoskeleton
.cytoplasm
32 EBI-295634,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites251
bladder167
blood73
bone181
bone marrow20
brain81
cervix164
connective tissue53
embryonic tissue234
esophagus49
eye100
heart78
intestine99
kidney52
larynx42
liver146
lung179
lymph180
lymph node77
mammary gland152
muscle94
nerve514
ovary167
pancreas84
parathyroid48
placenta286
prostate116
salivary gland98
skin593
spleen18
stomach104
testis73
thymus50
thyroid42
tonsil176
uterus168
Health State
TissuesTPM*
normal102
adrenal tumor237
bladder carcinoma170
breast (mammary gland) tumor214
cervical tumor115
chondrosarcoma132
colorectal tumor106
esophageal tumor57
gastrointestinal tumor202
germ cell tumor91
glioma195
head and neck tumor37
kidney tumor130
leukemia95
liver tumor83
lung tumor350
lymphoma235
non-neoplasia31
ovarian tumor170
pancreatic tumor95
primitive neuroectodermal tumor of the CNS196
prostate cancer202
retinoblastoma64
skin tumor901
soft tissue/muscle tissue tumor151
uterine tumor188
Developmental Stage
TissuesTPM*
adult149
embryoid body285
blastocyst244
fetus125
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue111.4
adrenal gland65.2
appendix97.2
bone marrow110.5
cerebral cortex59.8
colon88.2
duodenum78.5
esophagus72.5
gallbladder85.9
heart muscle98.7
kidney67.6
liver38.3
lung104.8
lymph node96.8
ovary80.5
pancreas45.2
placenta84.8
prostate87.6
salivary gland75.2
skin91.6
small intestine71.8
spleen120.3
stomach88.9
testis68.6
thyroid gland67.9
urinary bladder81.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasLow
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605065, gene) Cell division cycle 37, s. cerevisiae, homolog of; CDC37OMIM


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