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> Protein (NX_Q16555)
Protein (NX_Q16555)
Protein
Gene SymbolDPYSL2 to neXtProt (NX_Q16555)
DescriptionDihydropyrimidinase-related protein 2
Chromosome8
Location8p21.2 (26371791 ~ 26515694) to Ensembl
Sequene Features : Isoforms 2, Variants 60, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.synaptic vesicle transport
.response to drug
.response to cocaine
  + 11 more...
.dihydropyrimidinase activity .extracellular exosome
.protein complex
.terminal bouton
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 60 18
2014-09-19protein level
2 50 18
2014-05-27protein level
2 50 21
2014-02-25protein level
2 50 19
2013-12-09protein level
2 42 19
2013-11-01protein level
2 41 17
2013-09-12protein level
2 41 18
2013-08-17protein level
2 41 18
2013-07-15protein level
2 20 17
2013-06-11protein level
2 20 17
2013-02-12protein level
2 10 31
2012-12-20protein level
1 11 18
2012-10-30protein level
1 12 18
2012-10-07protein level
1 12 18
2012-08-24protein level
1 12 18
2012-07-28protein level
1 12 18
2012-06-08protein level
1 21 18
2012-05-07protein level
1 16 18
2012-04-10protein level
1 16 18
2012-01-13protein level
1 15 18
2011-12-20protein level
1 15 18
2011-11-11protein level
1 15 16
2011-08-23protein level
1 15 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16555-1
0 22 4 62254.3908
NX_Q16555-2
0 22 3 58126.256
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1104711,EBI-10232496 DPYSL3  
  .cellular response to cytokine stimulus
.actin crosslink formation
.positive regulation of filopodium assembly
  + 7 more...
.chondroitin sulfate binding
.SH3 domain binding
.hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
.exocytic vesicle
.cell body
.filamentous actin
  + 4 more...
2 EBI-1104711,EBI-724653 DPYSL5  
  .axon guidance
.nervous system development
.signal transduction
.hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds .neuronal cell body
.dendrite
.cytosol
3 EBI-1104711,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue777
adrenal gland91
ascites50
blood24
bone83
bone marrow61
brain517
cervix61
connective tissue60
ear186
embryonic tissue136
eye95
heart55
intestine51
kidney94
larynx42
liver53
lung122
lymph158
lymph node89
mammary gland92
mouth15
muscle188
nerve386
ovary59
pancreas23
parathyroid97
pharynx49
pituitary gland121
placenta31
prostate15
skin94
spleen18
stomach52
testis89
thymus25
thyroid21
trachea96
umbilical cord72
uterus90
vascular96
Health State
TissuesTPM*
normal209
breast (mammary gland) tumor64
cervical tumor86
chondrosarcoma60
colorectal tumor71
gastrointestinal tumor50
germ cell tumor136
glioma279
head and neck tumor14
kidney tumor188
leukemia42
liver tumor83
lung tumor48
lymphoma96
non-neoplasia134
ovarian tumor52
pancreatic tumor9
primitive neuroectodermal tumor of the CNS70
prostate cancer9
retinoblastoma107
skin tumor63
soft tissue/muscle tissue tumor87
uterine tumor11
Developmental Stage
TissuesTPM*
adult107
embryoid body142
blastocyst195
neonate32
fetus294
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue44.9
adrenal gland33.5
appendix22.4
bone marrow2.1
cerebral cortex192.9
colon19.1
duodenum9.4
esophagus18.1
gallbladder31.3
heart muscle35.5
kidney18
liver11.2
lung77.1
lymph node16.7
ovary37
pancreas4.9
placenta32.3
prostate12.2
salivary gland6.7
skin13.5
small intestine13.8
spleen32.2
stomach12.2
testis12.8
thyroid gland11.7
urinary bladder24.8
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeMedium
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602463, gene) Dihydropyrimidinase-like 2; DPYSL2OMIM


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