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> Protein (NX_Q16586)
Protein (NX_Q16586)
Protein
Gene SymbolSGCA to neXtProt (NX_Q16586)
DescriptionAlpha-sarcoglycan
Chromosome17
Location17q21.33 (48241575 ~ 48253292) to Ensembl
Sequene Features : Isoforms 2, Variants 88, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.muscle organ development
.muscle contraction
.calcium ion binding .membrane raft
.sarcolemma
.integral component of membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 88 2
2014-09-19protein level
2 67 2
2014-05-27protein level
2 67 2
2014-02-25protein level
2 67 2
2013-12-09protein level
2 54 2
2013-11-01protein level
2 53 2
2013-09-12protein level
2 53 2
2013-08-17protein level
2 53 2
2013-07-15protein level
2 45 2
2013-06-11protein level
2 45 2
2013-02-12protein level
2 35 3
2012-12-20protein level
2 32 3
2012-10-30protein level
2 36 3
2012-10-07protein level
2 36 2
2012-08-24protein level
2 35 2
2012-07-28protein level
2 35 2
2012-06-08protein level
2 35 2
2012-05-07protein level
2 34 2
2012-04-10protein level
2 34 2
2012-01-13protein level
2 34 2
2011-12-20protein level
2 34 2
2011-11-11protein level
2 34 2
2011-08-23protein level
2 34 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16586-1
6 11 0 42847.867
NX_Q16586-2
0 11 0 29336.0915
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5663553,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain3
connective tissue20
eye33
heart44
lung2
lymph22
muscle225
ovary19
placenta7
prostate15
stomach10
testis9
umbilical cord72
uterus12
Health State
TissuesTPM*
normal19
chondrosarcoma24
gastrointestinal tumor8
lymphoma13
non-neoplasia20
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult18
neonate32
fetus10
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.1
adrenal gland1.5
appendix6.7
colon5.5
duodenum5.6
esophagus22.3
gallbladder12.9
heart muscle97.9
kidney1.4
liver1.1
lung12.9
ovary2.5
placenta6.1
prostate19
salivary gland1
skin2.9
small intestine4.1
spleen2.6
stomach1.8
testis8.2
urinary bladder17.8
Tissues
TissuesExpression level
adrenal glandLow
appendixLow
breastLow
bronchusLow
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisLow
esophagusMedium
fallopian tubeLow
gallbladderLow
heart muscleMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
liverLow
lungMedium
lymph nodeLow
nasopharynxLow
oral mucosaMedium
ovaryLow
pancreasLow
parathyroid glandLow
placentaLow
rectumLow
salivary glandLow
seminal vesicleLow
skeletal muscleMedium
skin 1Low
small intestineLow
smooth muscleLow
soft tissue 1Medium
soft tissue 2Low
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilLow
urinary bladderLow
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600119, gene) Sarcoglycan, alpha; SGCAOMIM
2(#608099, phenotype) Muscular dystrophy, limb-girdle, type 2d; LGMD2DOMIM


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