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> Protein (NX_Q16611)
Protein (NX_Q16611)
Protein
Gene SymbolBAK1 to neXtProt (NX_Q16611)
DescriptionBcl-2 homologous antagonist/killer
Chromosome6
Location6p21.31 (33540329 ~ 33548019) to Ensembl
Sequene Features : Isoforms 2, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of IRE1-mediated unfolded protein response
.apoptotic process involved in patterning of blood vessels
.positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
  + 54 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
.identical protein binding
.pore complex
.integral component of mitochondrial outer membrane
.cytosol
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 24 1
2014-09-19protein level
1 15 1
2014-05-27protein level
1 15 1
2014-02-25protein level
1 15 1
2013-12-09protein level
1 13 1
2013-11-01protein level
1 13 1
2013-09-12protein level
1 13 1
2013-08-17protein level
1 13 1
2013-07-15protein level
1 8 0
2013-06-11protein level
1 8 0
2013-02-12protein level
1 6 0
2012-12-20protein level
1 6 0
2012-10-30protein level
1 6 0
2012-10-07protein level
1 6 0
2012-08-24protein level
1 5 0
2012-07-28protein level
1 5 0
2012-06-08protein level
1 6 0
2012-05-07protein level
1 6 0
2012-04-10protein level
1 6 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16611-1
5 5 0 23393.7912
NX_Q16611-2
2 5 0 16861.0361
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-519866,EBI-519672 BID  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
2 EBI-519866,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
3 EBI-519866,EBI-78035 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
4 EBI-519866,EBI-1003422 MCL1  
  .negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of response to DNA damage stimulus
  + 10 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
.protein channel activity
.Bcl-2 family protein complex
.integral component of membrane
.membrane
  + 7 more...
5 EBI-519866,EBI-1003550 BCL2A1  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic process
.intrinsic apoptotic signaling pathway in response to DNA damage
.protein heterodimerization activity
.protein homodimerization activity
.mitochondrial outer membrane
6 EBI-519866,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
bladder33
blood89
bone13
bone marrow61
brain10
cervix61
connective tissue13
embryonic tissue4
esophagus49
eye14
heart11
intestine43
kidney23
liver19
lung44
lymph90
lymph node33
mammary gland6
muscle9
ovary29
pancreas4
placenta42
prostate15
salivary gland49
skin33
spleen56
stomach62
testis13
thymus25
thyroid64
uterus64
vascular19
Health State
TissuesTPM*
normal19
bladder carcinoma56
cervical tumor28
chondrosarcoma24
colorectal tumor8
esophageal tumor57
gastrointestinal tumor50
germ cell tumor30
glioma37
head and neck tumor7
kidney tumor29
leukemia31
liver tumor10
lung tumor38
lymphoma83
non-neoplasia10
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS94
prostate cancer28
skin tumor39
soft tissue/muscle tissue tumor7
uterine tumor144
Developmental Stage
TissuesTPM*
adult30
blastocyst16
fetus12
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.3
adrenal gland10.7
appendix12.6
bone marrow10.5
cerebral cortex3.4
colon19
duodenum25.4
esophagus10.2
gallbladder7
heart muscle6.5
kidney5.8
liver2.2
lung6.8
lymph node13
ovary3.1
pancreas3.1
placenta6
prostate4.2
salivary gland4.4
skin7.3
small intestine19.3
spleen10.8
stomach13.8
testis4.1
thyroid gland3.1
urinary bladder12.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600516, gene) Bcl2 antagonist killer 1; BAK1OMIM


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