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> Protein (NX_Q16637)
Protein (NX_Q16637)
Protein
Gene SymbolSMN2 to neXtProt (NX_Q16637)
DescriptionSurvival motor neuron protein
Chromosome5
Location5q13.2 (69345350 ~ 69374349) to Ensembl
Sequene Features : Isoforms 4, Variants 17, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 17 14
2014-09-19protein level
4 17 14
2014-05-27protein level
4 17 14
2014-02-25protein level
4 17 14
2013-12-09protein level
4 16 14
2013-11-01protein level
4 16 11
2013-09-12protein level
4 16 11
2013-08-17protein level
4 16 11
2013-07-15protein level
4 16 11
2013-06-11protein level
4 16 11
2013-02-12protein level
4 16 40
2012-12-20protein level
4 17 40
2012-10-30protein level
4 19 37
2012-10-07protein level
4 19 10
2012-08-24protein level
4 19 10
2012-07-28protein level
4 19 10
2012-06-08protein level
4 19 10
2012-05-07protein level
4 19 10
2012-04-10protein level
4 21 10
2012-01-13protein level
4 27 8
2011-12-20protein level
4 21 8
2011-11-11protein level
4 27 8
2011-08-23protein level
4 17 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16637-1
1 9 0 31828.3969
NX_Q16637-2
1 8 0 28515.6749
NX_Q16637-3
1 9 0 30430.7351
NX_Q16637-4
1 8 0 27118.0131
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-395421,EBI-443648 GEMIN2  
  .ncRNA metabolic process
.gene expression
.RNA splicing
  + 4 more...
.N/A .Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 6 more...
2 EBI-395421,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
3 EBI-395447,EBI-372471 SNRPB  
  .activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
4 EBI-395421,EBI-396072 PPIG  
  .RNA splicing
.protein folding
.protein peptidyl-prolyl isomerization
.poly(A) RNA binding
.cyclosporin A binding
.peptidyl-prolyl cis-trans isomerase activity
.nuclear speck
.nuclear matrix
.cytoplasm
  + 2 more...
5 EBI-395421,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
6 EBI-395447,EBI-286758 KPNB1  
  .intracellular transport of virus
.small molecule metabolic process
.cytokine-mediated signaling pathway
  + 10 more...
.poly(A) RNA binding
.protein domain specific binding
.enzyme binding
  + 3 more...
.endoplasmic reticulum tubular network
.extracellular exosome
.nuclear membrane
  + 6 more...
7 EBI-395421,EBI-10175124 FAM9B  
  .spermatid development .N/A .nucleoplasm
8 EBI-395421,EBI-443630 GEMIN5  
  .ncRNA metabolic process
.gene expression
.protein complex assembly
  + 2 more...
.poly(A) RNA binding
.snRNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 6 more...
9 EBI-395421,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
10 EBI-395421,EBI-1018153 HNRNPUL1  
  .gene expression
.response to virus
.RNA splicing
  + 4 more...
.poly(A) RNA binding
.enzyme binding
.RNA binding
.ribonucleoprotein complex
.nucleoplasm
.nucleus
11 EBI-395421,EBI-465781 BLOC1S6  
  .membrane fusion
.membrane organization
.positive regulation of pigment cell differentiation
  + 12 more...
.actin filament binding
.protein homodimerization activity
.identical protein binding
.syntaxin binding
.BLOC-1 complex
.transport vesicle
.extrinsic component of membrane
  + 4 more...
12 EBI-395421,EBI-347794 CHTOP  
  .positive regulation of helicase activity
.positive regulation of ATPase activity
.mRNA export from nucleus
  + 2 more...
.poly(A) RNA binding .intracellular membrane-bounded organelle
.nuclear speck
.nucleolus
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder66
blood24
bone111
brain22
cervix103
connective tissue13
ear248
embryonic tissue98
eye52
heart67
intestine38
kidney71
larynx85
liver29
lung50
lymph node55
mammary gland39
mouth90
muscle56
nerve64
ovary39
pancreas28
pharynx24
pituitary gland121
placenta63
prostate10
salivary gland49
skin71
stomach156
testis34
thymus25
thyroid42
tonsil58
uterus47
vascular19
Health State
TissuesTPM*
normal21
adrenal tumor79
breast (mammary gland) tumor64
cervical tumor28
chondrosarcoma84
colorectal tumor62
gastrointestinal tumor177
germ cell tumor34
glioma27
head and neck tumor112
kidney tumor43
leukemia52
liver tumor10
lung tumor19
lymphoma13
non-neoplasia62
ovarian tumor52
pancreatic tumor19
primitive neuroectodermal tumor of the CNS47
prostate cancer9
retinoblastoma150
skin tumor7
soft tissue/muscle tissue tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult56
embryoid body85
blastocyst130
neonate32
fetus41
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.5
adrenal gland19.1
appendix27
bone marrow39.1
cerebral cortex18.9
colon22.3
duodenum14.5
esophagus21.7
gallbladder23.8
heart muscle16.6
kidney16.4
liver19.1
lung20.9
lymph node31.8
ovary20.1
pancreas12.1
placenta22.4
prostate20.9
salivary gland18.1
skin21.9
small intestine16.4
spleen22.1
stomach18.7
testis26.9
thyroid gland27.7
urinary bladder28.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowHigh
breastMedium
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Low
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleHigh
lungLow
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
pancreasHigh
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleLow
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#253300, phenotype) Spinal muscular atrophy, type i; SMA1OMIM
2(#253400, phenotype) Spinal muscular atrophy, type iii; SMA3OMIM
3(#253550, phenotype) Spinal muscular atrophy, type ii; SMA2OMIM
4(#271150, phenotype) Spinal muscular atrophy, type iv; SMA4OMIM
5(*600354, gene) Survival of motor neuron 1; SMN1OMIM
6(*601627, gene) Survival of motor neuron 2; SMN2OMIM


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