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> Protein (NX_Q16643)
Protein (NX_Q16643)
Protein
Gene SymbolDBN1 to neXtProt (NX_Q16643)
DescriptionDrebrin
Chromosome5
Location5q35.3 (176883609 ~ 176901402) to Ensembl
Sequene Features : Isoforms 3, Variants 87, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.neural precursor cell proliferation
.regulation of dendrite development
.regulation of neuronal synaptic plasticity
  + 4 more...
.profilin binding
.actin binding
.actomyosin
.dendrite
.actin cytoskeleton
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 87 17
2014-09-19protein level
3 74 17
2014-05-27protein level
3 74 17
2014-02-25protein level
3 74 17
2013-12-09protein level
3 60 17
2013-11-01protein level
3 56 17
2013-09-12protein level
2 56 18
2013-08-17protein level
2 56 18
2013-07-15protein level
2 35 18
2013-06-11protein level
2 35 18
2013-02-12protein level
2 23 30
2012-12-20protein level
2 21 30
2012-10-30protein level
2 22 30
2012-10-07protein level
2 22 16
2012-08-24protein level
2 18 16
2012-07-28protein level
2 18 16
2012-06-08protein level
2 18 16
2012-05-07protein level
2 18 16
2012-04-10protein level
2 18 16
2012-01-13protein level
2 11 16
2011-12-20protein level
2 11 16
2011-11-11protein level
2 11 15
2011-08-23protein level
2 11 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16643-1
0 27 0 71385.2393
NX_Q16643-2
2 24 0 71554.3254
NX_Q16643-3
4 26 0 76252.5052
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351394,EBI-365875 MLLT4  
  .establishment of endothelial intestinal barrier
.cell-cell junction organization
.positive regulation of GTPase activity
  + 5 more...
.Ras GTPase binding
.protein C-terminus binding
.apical part of cell
.cell junction
.cell-cell adherens junction
  + 5 more...
2 EBI-351394,EBI-696162 PTEN  
  .positive regulation of apoptotic signaling pathway
.negative regulation of synaptic vesicle clustering
.positive regulation of excitatory postsynaptic membrane potential
  + 91 more...
.phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
.inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
.PDZ domain binding
  + 10 more...
.postsynaptic membrane
.Schmidt-Lanterman incisure
.dendritic spine
  + 12 more...
3 EBI-351394,EBI-489411 CXCR4  
  .cellular response to cytokine stimulus
.chemokine-mediated signaling pathway
.neural precursor cell proliferation
  + 24 more...
.ubiquitin binding
.myosin light chain binding
.ubiquitin protein ligase binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.cell leading edge
  + 11 more...
4 EBI-351394,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
5 EBI-351394,EBI-8757328 DBN1  
  .neural precursor cell proliferation
.regulation of dendrite development
.regulation of neuronal synaptic plasticity
  + 4 more...
.profilin binding
.actin binding
.actomyosin
.dendrite
.actin cytoskeleton
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites25
bladder66
bone83
bone marrow41
brain258
cervix226
connective tissue46
embryonic tissue155
eye86
heart78
intestine51
kidney166
larynx170
liver9
lung71
lymph67
mammary gland46
mouth136
muscle65
nerve386
ovary68
pancreas23
placenta17
prostate26
skin71
spleen56
stomach20
testis105
thymus250
thyroid107
trachea19
umbilical cord145
uterus99
vascular135
Health State
TissuesTPM*
normal122
bladder carcinoma56
breast (mammary gland) tumor64
cervical tumor115
chondrosarcoma96
colorectal tumor26
gastrointestinal tumor25
germ cell tumor311
glioma195
head and neck tumor89
kidney tumor159
leukemia21
liver tumor10
lung tumor58
lymphoma41
non-neoplasia31
ovarian tumor65
pancreatic tumor38
primitive neuroectodermal tumor of the CNS236
prostate cancer19
retinoblastoma172
skin tumor63
soft tissue/muscle tissue tumor79
uterine tumor55
Developmental Stage
TissuesTPM*
adult84
embryoid body114
blastocyst227
neonate160
fetus333
infant42
juvenile251
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue27.7
adrenal gland9.5
appendix18.3
bone marrow4.6
cerebral cortex35.6
colon11
duodenum8.8
esophagus16.9
gallbladder24.6
heart muscle12.8
kidney20.9
liver2.9
lung17
lymph node8.6
ovary14.6
pancreas7.1
placenta7
prostate19.8
salivary gland19.4
skin4.5
small intestine10
spleen10.5
stomach12.6
testis21.7
thyroid gland22.6
urinary bladder24.3
Tissues
TissuesExpression level
appendixLow
bone marrowLow
breastLow
cerebellumMedium
cerebral cortexMedium
colonHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusLow
fallopian tubeLow
gallbladderMedium
hippocampusLow
kidneyMedium
lateral ventricleLow
lymph nodeMedium
nasopharynxLow
oral mucosaLow
ovaryLow
pancreasLow
parathyroid glandMedium
prostateLow
rectumLow
salivary glandMedium
soft tissue 2Low
spleenMedium
stomach 1Medium
stomach 2Medium
testisMedium
tonsilMedium
urinary bladderMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*126660, gene) Drebrin e; DBN1OMIM


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