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> Protein (NX_Q16649)
Protein (NX_Q16649)
Protein
Gene SymbolNFIL3 to neXtProt (NX_Q16649)
DescriptionNuclear factor interleukin-3-regulated protein
Chromosome9
Location9q22.31 (94171327 ~ 94186144) to Ensembl
Sequene Features : Isoforms 1, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to interleukin-4
.positive regulation of gene expression
.circadian rhythm
  + 3 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.DNA binding
  + 3 more...
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 48 5
2014-09-19protein level
1 35 5
2014-05-27protein level
1 35 5
2014-02-25protein level
1 35 5
2013-12-09protein level
1 30 5
2013-11-01protein level
1 29 5
2013-09-12protein level
1 29 5
2013-08-17protein level
1 29 5
2013-07-15protein level
1 17 5
2013-06-11protein level
1 17 5
2013-02-12protein level
1 6 4
2012-12-20protein level
1 6 4
2012-10-30protein level
1 7 4
2012-10-07protein level
1 7 4
2012-08-24protein level
1 6 4
2012-07-28protein level
1 6 4
2012-06-08protein level
1 13 4
2012-05-07protein level
1 13 4
2012-04-10protein level
1 13 4
2012-01-13protein level
1 9 4
2011-12-20protein level
1 9 4
2011-11-11protein level
1 9 3
2011-08-23protein level
1 9 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16649-1
21 0 0 51439.6695
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3951858,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
2 EBI-3951858,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
ascites25
blood16
bone55
brain11
cervix20
connective tissue33
esophagus49
eye4
heart67
intestine8
kidney80
larynx42
liver43
lung41
lymph node11
mammary gland26
muscle9
nerve64
ovary19
pancreas28
parathyroid48
pituitary gland121
placenta42
prostate31
skin9
stomach20
testis16
uterus25
vascular19
Health State
TissuesTPM*
normal24
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma84
esophageal tumor57
gastrointestinal tumor33
germ cell tumor34
glioma37
kidney tumor58
leukemia10
liver tumor31
lung tumor38
ovarian tumor26
pancreatic tumor28
primitive neuroectodermal tumor of the CNS15
prostate cancer19
skin tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult28
fetus32
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue62.2
adrenal gland82.5
appendix38
bone marrow121.9
cerebral cortex9.4
colon18.5
duodenum16.7
esophagus22.3
gallbladder49.9
heart muscle14.8
kidney14.7
liver41.8
lung19.1
lymph node9.2
ovary30.8
pancreas14.6
placenta42
prostate29
salivary gland6
skin8.7
small intestine16.2
spleen9.9
stomach11.2
testis18.8
thyroid gland10.8
urinary bladder36.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605327, gene) Nuclear factor, interleukin 3-regulated; NFIL3OMIM


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