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> Protein (NX_Q16656)
Protein (NX_Q16656)
Protein
Gene SymbolNRF1 to neXtProt (NX_Q16656)
DescriptionNuclear respiratory factor 1
Chromosome7
Location7q32.2 (129251555 ~ 129396922) to Ensembl
Sequene Features : Isoforms 4, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to electrical stimulus
.response to folic acid
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 43 7
2014-09-19protein level
4 29 7
2014-05-27protein level
4 29 7
2014-02-25protein level
2 29 7
2013-12-09protein level
2 29 7
2013-11-01protein level
2 26 7
2013-09-12protein level
2 26 7
2013-08-17protein level
2 26 7
2013-07-15protein level
2 19 6
2013-06-11protein level
2 19 6
2013-02-12protein level
2 4 10
2012-12-20protein level
2 4 10
2012-10-30protein level
2 4 10
2012-10-07protein level
2 4 5
2012-08-24protein level
2 3 5
2012-07-28protein level
2 3 5
2012-06-08protein level
2 4 5
2012-05-07protein level
2 2 5
2012-04-10protein level
2 2 5
2012-01-13protein level
2 3 5
2011-12-20protein level
2 3 5
2011-11-11protein level
2 3 5
2011-08-23protein level
2 3 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16656-1
0 11 0 53507.6979
NX_Q16656-2
1 9 0 46128.0127
NX_Q16656-3
1 5 0 36028.8992
NX_Q16656-4
2 10 0 55638.8277
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2547810,EBI-10198587 SP4  
  .regulation of heart contraction
.transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.transcription coactivator activity
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.intercellular bridge
.microtubule cytoskeleton
.cytoplasm
.nucleoplasm
2 EBI-2547810,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
3 EBI-2547810,EBI-701903 FHL2  
  .heart trabecula formation
.ventricular cardiac muscle cell development
.atrial cardiac muscle cell development
  + 9 more...
.androgen receptor binding
.identical protein binding
.zinc ion binding
  + 2 more...
.M band
.Z disc
.actin cytoskeleton
  + 3 more...
4 EBI-2547810,EBI-1389308 POGZ  
  .kinetochore assembly
.cell division
.mitotic sister chromatid cohesion
.metal ion binding
.DNA binding
.cytoplasm
.nucleoplasm
.nucleus
.nuclear chromatin
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites125
bladder33
blood24
bone41
bone marrow20
brain11
cervix41
embryonic tissue18
esophagus49
eye43
heart22
intestine17
kidney18
liver19
lung5
lymph node55
nerve64
pancreas28
placenta7
prostate21
skin14
stomach20
testis16
thymus37
thyroid21
trachea19
uterus8
Health State
TissuesTPM*
normal16
cervical tumor57
colorectal tumor8
esophageal tumor57
gastrointestinal tumor50
germ cell tumor34
head and neck tumor7
leukemia21
liver tumor31
lung tumor9
lymphoma27
pancreatic tumor19
primitive neuroectodermal tumor of the CNS62
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor11
Developmental Stage
TissuesTPM*
adult15
embryoid body14
blastocyst32
fetus10
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.5
adrenal gland4.6
appendix7.2
bone marrow10.1
cerebral cortex5.7
colon6.4
duodenum6.2
esophagus7.4
gallbladder6.2
heart muscle6
kidney6
liver2.4
lung8.3
lymph node11.9
ovary15.6
pancreas3.6
placenta7.9
prostate6.7
salivary gland5.3
skin7.4
small intestine7
spleen9
stomach6.5
testis8.2
thyroid gland10.5
urinary bladder7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600879, gene) Nuclear respiratory factor 1; NRF1OMIM


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