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> Protein (NX_Q16665)
Protein (NX_Q16665)
Protein
Gene SymbolHIF1A to neXtProt (NX_Q16665)
DescriptionHypoxia-inducible factor 1-alpha
Chromosome14
Location14q23.2 (62162231 ~ 62214976) to Ensembl
Sequene Features : Isoforms 3, Variants 92, PTMs 22 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 92 22
2014-09-19protein level
3 72 22
2014-05-27protein level
3 72 21
2014-02-25protein level
3 70 21
2013-12-09protein level
3 55 21
2013-11-01protein level
3 55 20
2013-09-12protein level
3 55 20
2013-08-17protein level
3 55 20
2013-07-15protein level
3 31 15
2013-06-11protein level
3 31 15
2013-02-12protein level
3 15 43
2012-12-20protein level
2 15 28
2012-10-30protein level
2 21 28
2012-10-07protein level
2 21 15
2012-08-24protein level
2 21 15
2012-07-28protein level
2 21 15
2012-06-08protein level
2 53 15
2012-05-07protein level
2 45 15
2012-04-10protein level
2 45 15
2012-01-13protein level
2 37 15
2011-12-20protein level
2 37 15
2011-11-11protein level
2 33 9
2011-08-23protein level
2 33 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16665-1
0 34 0 92611.4464
NX_Q16665-2
1 29 0 82693.5564
NX_Q16665-3
1 33 0 95572.9398
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-447269,EBI-722425 CBX4  
  .negative regulation of transcription, DNA-templated
.cellular protein metabolic process
.post-translational protein modification
  + 5 more...
.transcription regulatory region DNA binding
.SUMO binding
.enzyme binding
  + 5 more...
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 2 more...
2 EBI-447269,EBI-1993627 UBXN7  
  .N/A .ubiquitin binding
.ubiquitin protein ligase binding
.transcription factor binding
.Cdc48p-Npl4p-Ufd1p AAA ATPase complex
.nucleoplasm
3 EBI-447269,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-447269,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
5 EBI-447269,EBI-4304679 PKM  
  .canonical glycolysis
.small molecule metabolic process
.programmed cell death
  + 2 more...
.poly(A) RNA binding
.potassium ion binding
.MHC class II protein complex binding
  + 3 more...
.extracellular exosome
.vesicle
.extracellular matrix
  + 6 more...
6 EBI-447269,EBI-80809 ARNT  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.positive regulation of hormone biosynthetic process
  + 14 more...
.protein heterodimerization activity
.enhancer binding
.aryl hydrocarbon receptor binding
  + 4 more...
.RNA polymerase II transcription factor complex
.cytoplasm
.nucleoplasm
.nucleus
7 EBI-447269,EBI-301246 VHL  
  .cellular response to hypoxia
.negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 10 more...
.ubiquitin protein ligase activity
.enzyme binding
.transcription factor binding
.ubiquitin-protein transferase activity
.intermediate filament cytoskeleton
.VCB complex
.membrane
  + 5 more...
8 EBI-447269,EBI-1050865 USP8  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 6 more...
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.extrinsic component of endosome membrane
.midbody
.extrinsic component of plasma membrane
  + 6 more...
9 EBI-447269,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
10 EBI-447269,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
11 EBI-447269,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
12 EBI-447269,EBI-714236 MTA1  
  .negative regulation of nucleic acid-templated transcription
.positive regulation of protein autoubiquitination
.regulation of inflammatory response
  + 11 more...
.zinc ion binding
.transcription corepressor activity
.transcription coactivator activity
  + 5 more...
.intracellular membrane-bounded organelle
.NuRD complex
.microtubule
  + 4 more...
13 EBI-447269,EBI-725454 OS9  
  .protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.response to endoplasmic reticulum stress
.ER-associated ubiquitin-dependent protein catabolic process
  + 3 more...
.carbohydrate binding
.glycoprotein binding
.endoplasmic reticulum quality control compartment
.endoplasmic reticulum lumen
.Hrd1p ubiquitin ligase complex
14 EBI-447269,EBI-473160 PIAS4  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.positive regulation of keratinocyte apoptotic process
.negative regulation of transcription, DNA-templated
  + 8 more...
.SUMO ligase activity
.ubiquitin protein ligase binding
.SUMO transferase activity
  + 3 more...
.PML body
.nuclear matrix
.cytoplasm
  + 2 more...
15 EBI-447269,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
16 EBI-447269,EBI-477430 KAT2B  
  .rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of cyclin-dependent protein serine/threonine kinase activity
  + 19 more...
.histone deacetylase binding
.protein complex binding
.protein kinase binding
  + 7 more...
.actomyosin
.I band
.A band
  + 5 more...
17 EBI-447269,EBI-726614 EGLN2  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.positive regulation of protein catabolic process
  + 6 more...
.peptidyl-proline 4-dioxygenase activity
.L-ascorbic acid binding
.oxygen sensor activity
  + 2 more...
.cytosol
.nucleoplasm
.nucleus
18 EBI-447269,EBI-1174818 EGLN1  
  .response to nitric oxide
.cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 11 more...
.peptidyl-proline 4-dioxygenase activity
.peptidyl-proline dioxygenase activity
.L-ascorbic acid binding
  + 3 more...
.cytosol
.cytoplasm
.nucleus
19 EBI-447269,EBI-1175354 EGLN3  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of neuron apoptotic process
  + 7 more...
.peptidyl-proline 4-dioxygenase activity
.L-ascorbic acid binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
.iron ion binding
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
20 EBI-447269,EBI-745632 HIF1AN  
  .positive regulation of vasculogenesis
.cellular response to hypoxia
.negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
  + 8 more...
.ankyrin repeat binding
.NF-kappaB binding
.cofactor binding
  + 9 more...
.perinuclear region of cytoplasm
.cytosol
.cytoplasm
.nucleoplasm
21 EBI-447269,EBI-851558 SEPT9  
  .cell division
.protein heterooligomerization
.metabolic process
.cell cycle
.GTP binding
.GTPase activity
.perinuclear region of cytoplasm
.actin cytoskeleton
.microtubule
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland212
ascites225
bladder401
blood179
bone167
bone marrow205
brain355
cervix61
connective tissue355
ear62
embryonic tissue258
esophagus496
eye52
heart11
intestine133
kidney175
larynx127
liver112
lung164
lymph45
lymph node111
mammary gland112
mouth695
muscle159
ovary59
pancreas98
pharynx147
pituitary gland121
placenta123
prostate126
salivary gland148
skin204
spleen149
stomach94
testis307
thymus313
thyroid193
trachea1796
umbilical cord145
uterus344
vascular522
Health State
TissuesTPM*
normal5
adrenal tumor79
bladder carcinoma56
cervical tumor28
colorectal tumor8
esophageal tumor57
gastrointestinal tumor16
glioma9
head and neck tumor7
kidney tumor14
leukemia10
liver tumor10
lung tumor9
ovarian tumor13
pancreatic tumor19
prostate cancer28
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult152
embryoid body428
blastocyst195
neonate514
fetus161
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue59.6
adrenal gland144
appendix158.2
bone marrow346.2
cerebral cortex54.1
colon49.1
duodenum32.8
esophagus66.1
gallbladder169.4
heart muscle29.9
kidney70.1
liver31.6
lung44
lymph node78.4
ovary35.5
pancreas17.9
placenta65
prostate45.1
salivary gland33.5
skin24.3
small intestine38.1
spleen65.4
stomach41.2
testis39.5
thyroid gland55.4
urinary bladder110.7
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowHigh
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexHigh
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
epididymisLow
esophagusLow
gallbladderMedium
hippocampusLow
kidneyLow
lateral ventricleLow
lungLow
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
pancreasHigh
placentaHigh
rectumMedium
salivary glandLow
seminal vesicleLow
skin 1Low
skin 2Low
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandLow
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*603348, gene) Hypoxia-inducible factor 1, alpha subunit; HIF1AOMIM


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