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> Protein (NX_Q16666)
Protein (NX_Q16666)
Protein
Gene SymbolIFI16 to neXtProt (NX_Q16666)
DescriptionGamma-interferon-inducible protein 16
Chromosome1
Location1q23.1 (158969758 ~ 159024945) to Ensembl
Sequene Features : Isoforms 4, Variants 134, PTMs 27 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cysteine-type endopeptidase activity
.activation of cysteine-type endopeptidase activity
.intrinsic apoptotic signaling pathway by p53 class mediator
  + 23 more...
.poly(A) RNA binding
.identical protein binding
.transcription factor binding
  + 4 more...
.nuclear speck
.membrane
.cytosol
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 134 27
2014-09-19protein level
4 114 27
2014-05-27protein level
4 114 27
2014-02-25protein level
4 113 27
2013-12-09protein level
4 89 24
2013-11-01protein level
4 89 23
2013-09-12protein level
4 89 23
2013-08-17protein level
5 89 23
2013-07-15protein level
5 50 18
2013-06-11protein level
5 50 18
2013-02-12protein level
5 26 66
2012-12-20protein level
5 28 66
2012-10-30protein level
3 31 44
2012-10-07protein level
3 31 16
2012-08-24protein level
3 28 7
2012-07-28protein level
3 28 7
2012-06-08protein level
3 31 7
2012-05-07protein level
3 30 7
2012-04-10protein level
3 30 7
2012-01-13protein level
3 18 7
2011-12-20protein level
3 18 7
2011-11-11protein level
3 18 4
2011-08-23protein level
4 18 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16666-1
0 30 3 88199.1824
NX_Q16666-2
0 29 3 82043.3003
NX_Q16666-3
0 28 3 75887.4182
NX_Q16666-6
1 27 3 82535.3354
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6273540,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-2867186,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
3 EBI-2867186,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
4 EBI-2867186,EBI-2800345 TMEM173  
  .cellular response to exogenous dsRNA
.defense response to virus
.positive regulation of transcription from RNA polymerase II promoter
  + 11 more...
.cyclic-GMP-AMP binding
.protein homodimerization activity
.identical protein binding
  + 3 more...
.perinuclear region of cytoplasm
.cytoplasmic vesicle membrane
.integral component of membrane
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder133
blood212
bone209
bone marrow61
brain41
cervix103
connective tissue288
ear62
embryonic tissue56
esophagus248
eye28
heart100
intestine77
kidney52
larynx298
liver38
lung107
lymph22
lymph node300
mammary gland85
mouth136
muscle112
ovary49
pancreas56
pharynx122
placenta42
prostate47
salivary gland98
skin170
spleen112
stomach146
testis45
thymus401
thyroid64
trachea77
uterus211
vascular271
Health State
TissuesTPM*
normal77
adrenal tumor79
bladder carcinoma227
breast (mammary gland) tumor107
cervical tumor86
chondrosarcoma205
colorectal tumor79
esophageal tumor289
gastrointestinal tumor109
germ cell tumor83
glioma65
head and neck tumor149
kidney tumor29
leukemia179
liver tumor20
lung tumor116
lymphoma96
non-neoplasia82
ovarian tumor26
pancreatic tumor85
primitive neuroectodermal tumor of the CNS86
prostate cancer9
skin tumor135
soft tissue/muscle tissue tumor231
uterine tumor155
Developmental Stage
TissuesTPM*
adult100
embryoid body85
blastocyst32
neonate418
fetus78
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue81.3
adrenal gland43
appendix121.5
bone marrow23
cerebral cortex22.4
colon39.2
duodenum24.9
esophagus65.5
gallbladder113.8
heart muscle25
kidney16.1
liver16.2
lung60
lymph node155.4
ovary77.3
pancreas9
placenta52.2
prostate24.7
salivary gland21.4
skin64
small intestine30.7
spleen106.6
stomach34.8
testis26.8
thyroid gland22.7
urinary bladder112.6
Tissues
TissuesExpression level
appendixHigh
bone marrowMedium
bronchusMedium
cerebral cortexLow
colonLow
endometrium 1Medium
endometrium 2Medium
epididymisLow
esophagusMedium
fallopian tubeLow
kidneyMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaLow
ovaryMedium
seminal vesicleLow
skin 1Medium
spleenMedium
tonsilHigh
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*147586, gene) Interferon-gamma-inducible protein 16; IFI16OMIM


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