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> Protein (NX_Q16827)
Protein (NX_Q16827)
Protein
Gene SymbolPTPRO to neXtProt (NX_Q16827)
DescriptionReceptor-type tyrosine-protein phosphatase O
Chromosome12
Location12p12.3 (15475331 ~ 15750333) to Ensembl
Sequene Features : Isoforms 5, Variants 164, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of retinal ganglion cell axon guidance
.negative regulation of canonical Wnt signaling pathway
.glomerular visceral epithelial cell differentiation
  + 12 more...
.protein homodimerization activity
.Wnt-protein binding
.phosphatase activity
  + 2 more...
.extracellular exosome
.dendritic spine
.neuron projection
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 164 16
2014-09-19protein level
5 129 16
2014-05-27protein level
5 129 16
2014-02-25protein level
4 127 16
2013-12-09protein level
4 106 16
2013-11-01protein level
4 99 16
2013-09-12protein level
4 99 15
2013-08-17protein level
4 99 15
2013-07-15protein level
4 70 15
2013-06-11protein level
4 70 15
2013-02-12protein level
4 32 30
2012-12-20protein level
4 33 30
2012-10-30protein level
4 37 30
2012-10-07protein level
4 37 16
2012-08-24protein level
4 35 16
2012-07-28protein level
4 35 16
2012-06-08protein level
4 52 16
2012-05-07protein level
4 33 16
2012-04-10protein level
2 33 16
2012-01-13protein level
2 24 16
2011-12-20protein level
2 24 16
2011-11-11protein level
2 24 16
2011-08-23protein level
2 24 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q16827-1
0 41 1 138254.8881
NX_Q16827-2
0 40 1 134854.1139
NX_Q16827-3
0 15 1 47132.5572
NX_Q16827-4
0 14 1 43731.783
NX_Q16827-5
1 19 0 67628.594
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-723739,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
2 EBI-723739,EBI-2257090 TEK  
  .negative regulation of endothelial cell apoptotic process
.regulation of endothelial cell apoptotic process
.positive regulation of actin cytoskeleton reorganization
  + 45 more...
.ATP binding
.receptor activity
.transmembrane receptor protein tyrosine kinase activity
  + 2 more...
.perinuclear region of cytoplasm
.membrane raft
.apical plasma membrane
  + 10 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood49
bone marrow82
brain96
connective tissue26
eye14
heart22
intestine34
kidney66
lung14
lymph node22
mammary gland52
muscle47
nerve64
placenta3
prostate5
spleen56
testis25
trachea19
uterus8
Health State
TissuesTPM*
normal45
breast (mammary gland) tumor85
colorectal tumor44
germ cell tumor117
glioma9
leukemia31
non-neoplasia51
primitive neuroectodermal tumor of the CNS39
uterine tumor11
Developmental Stage
TissuesTPM*
adult29
neonate160
fetus149
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.3
adrenal gland1.2
appendix4
cerebral cortex14
colon12.2
duodenum1.9
gallbladder1.9
kidney19.1
lung5.1
lymph node4.4
placenta4.1
small intestine2.2
spleen3.9
stomach1.3
testis1.2
urinary bladder2.2
Tissues
TissuesExpression level
kidneyHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600579, gene) Protein-tyrosine phosphatase, receptor-type, o; PTPROOMIM
2(#614196, phenotype) Nephrotic syndrome, type 6; NPHS6OMIM


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