Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q17RB8)
Protein (NX_Q17RB8)
Protein
Gene SymbolLONRF1 to neXtProt (NX_Q17RB8)
DescriptionLON peptidase N-terminal domain and RING finger protein 1
Chromosome8
Location8p23.1 (12579403 ~ 12613582) to Ensembl
Sequene Features : Isoforms 2, Variants 53, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 53 1
2014-09-19protein level
2 43 1
2014-05-27protein level
2 43 1
2014-02-25protein level
2 43 1
2013-12-09protein level
2 29 1
2013-11-01protein level
2 29 1
2013-09-12protein level
2 29 1
2013-08-17protein level
2 29 1
2013-07-15protein level
2 17 1
2013-06-11protein level
2 17 1
2013-02-12transcript level
2 8 0
2012-12-20transcript level
2 13 0
2012-10-30transcript level
2 16 0
2012-10-07transcript level
2 16 0
2012-08-24transcript level
2 11 0
2012-07-28transcript level
2 11 0
2012-06-08transcript level
2 13 0
2012-05-07transcript level
2 13 0
2012-04-10transcript level
2 13 0
2012-01-13transcript level
2 5 0
2011-12-20transcript level
2 5 0
2011-11-11transcript level
2 5 0
2011-08-23transcript level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q17RB8-1
1 39 0 86668.6128
NX_Q17RB8-2
1 39 0 85418.0848
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2341787,EBI-2129974 UBE2L6  
  .innate immune response
.negative regulation of type I interferon production
.ISG15-protein conjugation
  + 5 more...
.ISG15 transferase activity
.ligase activity
.ubiquitin-protein transferase activity
.cytosol
.nucleoplasm
2 EBI-2341787,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
3 EBI-2341787,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
4 EBI-2341787,EBI-358174 STAU1  
  .positive regulation by virus of viral protein levels in host cell
.positive regulation of viral genome replication
.intracellular mRNA localization
.poly(A) RNA binding
.double-stranded RNA binding
.extracellular exosome
.cell body
.neuronal cell body
  + 9 more...
5 EBI-2341787,EBI-3905054 ALAS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
6 EBI-2341787,EBI-721550 NR4A1  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 13 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 2 more...
.nuclear membrane
.cytoplasm
.nucleoplasm
.nucleus
7 EBI-2341787,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
8 EBI-2341787,EBI-517127 XIAP  
  .inhibition of cysteine-type endopeptidase activity involved in apoptotic process
.positive regulation of protein linear polyubiquitination
.intrinsic apoptotic signaling pathway
  + 15 more...
.ubiquitin protein ligase activity
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 2 more...
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
9 EBI-2341787,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
10 EBI-2341787,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
11 EBI-2341787,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
12 EBI-2341787,EBI-2349927 EFHC2  
  .N/A .calcium ion binding .N/A
13 EBI-2341787,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
14 EBI-2341787,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
15 EBI-2341787,EBI-727146 ATG9A  
  .innate immune response
.late nucleophagy
.piecemeal microautophagy of nucleus
  + 5 more...
.N/A .recycling endosome
.late endosome membrane
.cytoplasmic vesicle
  + 8 more...
16 EBI-2341787,EBI-10238842 IQCF2  
  .N/A .N/A .N/A
17 EBI-2341787,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
18 EBI-2341787,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
19 EBI-2341787,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
20 EBI-2341787,EBI-2865388 LHX4  
  .negative regulation of apoptotic process
.medial motor column neuron differentiation
.organ morphogenesis
  + 4 more...
.sequence-specific DNA binding
.zinc ion binding
.nucleus
21 EBI-2341787,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
22 EBI-2341787,EBI-2561458 GORASP1  
  .negative regulation of dendrite morphogenesis
.protein transport
.Golgi organization
.mitotic cell cycle
.N/A .Golgi apparatus
.Golgi membrane
23 EBI-2341787,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
24 EBI-2341787,EBI-3893057 IKZF2  
  .positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood16
bone marrow20
brain10
connective tissue13
embryonic tissue28
eye28
heart55
intestine21
kidney14
larynx42
liver19
lung14
lymph node100
mouth60
muscle9
nerve128
ovary29
pancreas14
placenta24
prostate73
skin18
testis43
trachea38
uterus25
Health State
TissuesTPM*
normal25
chondrosarcoma24
colorectal tumor26
germ cell tumor26
glioma18
head and neck tumor37
leukemia21
liver tumor10
non-neoplasia10
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS15
prostate cancer125
skin tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult28
embryoid body14
blastocyst48
neonate32
fetus30
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue32.5
adrenal gland17.3
appendix14
bone marrow15.1
cerebral cortex14.7
colon10
duodenum5.4
esophagus28.6
gallbladder21.9
heart muscle7.2
kidney9.4
liver12.5
lung17.7
lymph node15.6
ovary30.8
pancreas8.5
placenta16.3
prostate18.9
salivary gland16.6
skin61.3
small intestine6.9
spleen20.2
stomach7.7
testis24.9
thyroid gland19.1
urinary bladder13.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center