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> Protein (NX_Q2NKJ3)
Protein (NX_Q2NKJ3)
Protein
Gene SymbolCTC1 to neXtProt (NX_Q2NKJ3)
DescriptionCST complex subunit CTC1
Chromosome17
Location17p13.1 (8130191 ~ 8151362) to Ensembl
Sequene Features : Isoforms 2, Variants 111, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.replicative senescence
.hematopoietic stem cell proliferation
.bone marrow development
  + 9 more...
.single-stranded DNA binding .Stn1-Ten1 complex
.nucleus
.nuclear chromosome, telomeric region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 111 4
2014-09-19protein level
2 90 4
2014-05-27protein level
2 90 4
2014-02-25protein level
2 89 4
2013-12-09protein level
2 57 4
2013-11-01protein level
2 55 4
2013-09-12protein level
2 55 4
2013-08-17protein level
2 55 4
2013-07-15protein level
2 37 0
2013-06-11protein level
2 37 0
2013-02-12protein level
2 24 0
2012-12-20protein level
2 20 0
2012-10-30protein level
2 28 0
2012-10-07protein level
2 28 0
2012-08-24protein level
2 26 0
2012-07-28protein level
2 26 0
2012-06-08protein level
2 32 0
2012-05-07protein level
2 31 0
2012-04-10protein level
2 20 0
2012-01-13protein level
2 15 0
2011-12-20protein level
2 15 0
2011-11-11protein level
2 15 0
2011-08-23protein level
2 15 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q2NKJ3-1
11 45 0 134522.2277
NX_Q2NKJ3-2
1 45 0 114069.2585
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2562802,EBI-743771 APPBP2  
  .intracellular transport
.metabolic process
.intracellular protein transport
.microtubule motor activity .cytoplasmic vesicle membrane
.microtubule associated complex
.microtubule
  + 2 more...
2 EBI-2562802,EBI-746930 OBFC1  
  .positive regulation of DNA replication
.telomere maintenance via telomere lengthening
.telomere maintenance
.single-stranded telomeric DNA binding
.single-stranded DNA binding
.Stn1-Ten1 complex
.intermediate filament cytoskeleton
.intracellular membrane-bounded organelle
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood40
bone27
brain29
connective tissue13
embryonic tissue14
eye14
intestine30
kidney14
liver14
lung41
lymph45
lymph node100
mammary gland46
mouth15
ovary19
pancreas18
placenta10
prostate15
skin4
spleen18
stomach10
testis29
thymus100
thyroid42
tonsil58
uterus43
Health State
TissuesTPM*
normal19
breast (mammary gland) tumor64
chondrosarcoma36
colorectal tumor26
gastrointestinal tumor8
germ cell tumor15
glioma27
head and neck tumor14
kidney tumor14
leukemia127
liver tumor10
lung tumor97
lymphoma41
non-neoplasia10
ovarian tumor13
pancreatic tumor9
prostate cancer19
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult30
embryoid body14
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue12.6
adrenal gland13
appendix32.6
bone marrow22.7
cerebral cortex15.6
colon13.1
duodenum18.6
esophagus8.7
gallbladder15.4
heart muscle8.4
kidney11.2
liver5.9
lung23.1
lymph node45.4
ovary20.9
pancreas13.3
placenta14.2
prostate12.4
salivary gland10.2
skin15.4
small intestine18.4
spleen43.3
stomach17.7
testis13.1
thyroid gland15.6
urinary bladder16.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#612199, phenotype) Cerebroretinal microangiopathy with calcifications and cysts; CRMCCOMIM
2(*613129, gene) Conserved telomere maintenance component 1; CTC1OMIM


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