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> Protein (NX_Q2TAC2)
Protein (NX_Q2TAC2)
Protein
Gene SymbolCCDC57 to neXtProt (NX_Q2TAC2)
DescriptionCoiled-coil domain-containing protein 57
Chromosome17
Location17q25.3 (80059336 ~ 80170706) to Ensembl
Sequene Features : Isoforms 2, Variants 95, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 95 0
2014-09-19protein level
2 75 0
2014-05-27transcript level
2 75 0
2014-02-25transcript level
2 74 0
2013-12-09transcript level
2 52 0
2013-11-01transcript level
2 52 0
2013-09-12transcript level
2 52 0
2013-08-17transcript level
2 52 0
2013-07-15transcript level
2 40 0
2013-06-11transcript level
2 40 0
2013-02-12transcript level
2 22 0
2012-12-20transcript level
2 22 0
2012-10-30transcript level
2 28 0
2012-10-07transcript level
2 28 0
2012-08-24transcript level
2 24 0
2012-07-28transcript level
2 24 0
2012-06-08transcript level
2 25 0
2012-05-07transcript level
2 25 0
2012-04-10transcript level
2 25 0
2012-01-13transcript level
2 18 0
2011-12-20transcript level
2 18 0
2011-11-11transcript level
2 18 0
2011-08-23transcript level
2 18 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q2TAC2-1
7 36 0 103104.1015
NX_Q2TAC2-2
0 36 0 85413.3019
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2808286,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
2 EBI-2808286,EBI-348444 NELFE  
  .negative regulation of mRNA polyadenylation
.positive regulation of viral transcription
.negative regulation of transcription elongation from RNA polymerase II promoter
  + 4 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.NELF complex
.mitochondrion
.nucleoplasm
.nucleus
3 EBI-2808286,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
4 EBI-2808286,EBI-2265723 PTPN7  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.protein tyrosine phosphatase activity .cytoplasmic side of plasma membrane
.cytoskeleton
.cytosol
.cytoplasm
5 EBI-2808286,EBI-2875746 ARL4A  
  .brown fat cell differentiation
.small GTPase mediated signal transduction
.GTP binding .plasma membrane
.cytoplasm
.nucleolus
.nucleus
6 EBI-2808286,EBI-1048159 MFAP1  
  .extracellular matrix organization .poly(A) RNA binding .extracellular region
.microfibril
7 EBI-2808286,EBI-714680 HBA2  
  .oxidation-reduction process
.protein heterooligomerization
.small molecule metabolic process
  + 6 more...
.heme binding
.oxygen binding
.iron ion binding
.oxygen transporter activity
.blood microparticle
.endocytic vesicle lumen
.extracellular exosome
  + 6 more...
8 EBI-2808286,EBI-2803328 PRR3  
  .N/A .metal ion binding
.poly(A) RNA binding
.N/A
9 EBI-2808286,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
10 EBI-2808286,EBI-521611 NUMA1  
  .lung epithelial cell differentiation
.meiotic cell cycle
.cell division
  + 5 more...
.structural molecule activity .extracellular exosome
.apical part of cell
.neuronal cell body
  + 11 more...
11 EBI-2808286,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
12 EBI-2808286,EBI-10241197 TSGA10IP  
  .N/A .N/A .N/A
13 EBI-2808286,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
14 EBI-2808286,EBI-10254820 NAPRT  
  .small molecule metabolic process
.NAD metabolic process
.nicotinate nucleotide salvage
  + 5 more...
.ligase activity
.nicotinate phosphoribosyltransferase activity
.nicotinate-nucleotide diphosphorylase (carboxylating) activity
.extracellular exosome
.cytosol
.Golgi apparatus
  + 3 more...
15 EBI-2808286,EBI-10260504 CDC20B  
  .N/A .N/A .N/A
16 EBI-2808286,EBI-6658203 FAM90A1  
  .N/A .zinc ion binding
.nucleic acid binding
.N/A
17 EBI-2808286,EBI-10181988 CEP57L1  
  .microtubule anchoring .N/A .microtubule
.microtubule organizing center
.cytoplasm
18 EBI-2808286,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
19 EBI-2808286,EBI-474076 PPHLN1  
  .keratinization .poly(A) RNA binding .intracellular membrane-bounded organelle
.Golgi apparatus
.cytoplasm
.nucleoplasm
20 EBI-2808286,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
21 EBI-2808286,EBI-743796 RAB3IL1  
  .positive regulation of GTPase activity
.protein transport
.Rab guanyl-nucleotide exchange factor activity .N/A
22 EBI-2808286,EBI-746309 GPKOW  
  .N/A .nucleic acid binding .nucleoplasm
23 EBI-2808286,EBI-726510 LENG1  
  .N/A .N/A .N/A
24 EBI-2808286,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
25 EBI-2808286,EBI-10286106 LINC00526  
  .N/A .N/A .N/A
26 EBI-2808286,EBI-10185348 CCDC120  
  .N/A .N/A .N/A
27 EBI-2808286,EBI-2682299 ZMAT2  
  .N/A .zinc ion binding
.DNA binding
.nucleus
28 EBI-2808286,EBI-2860740 PRAM1  
  .regulation of neutrophil degranulation
.integrin-mediated signaling pathway
.lipid binding .N/A
29 EBI-2808286,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
30 EBI-2808286,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
31 EBI-2808286,EBI-8644968 TMEM100  
  .positive regulation of vasculogenesis
.cellular response to BMP stimulus
.arterial endothelial cell differentiation
  + 8 more...
.N/A .perinuclear region of cytoplasm
.perikaryon
.integral component of membrane
  + 2 more...
32 EBI-2808286,EBI-742802 FAM50B  
  .N/A .N/A .nucleus
33 EBI-2808286,EBI-1043104 USP15  
  .regulation of proteasomal protein catabolic process
.pathway-restricted SMAD protein phosphorylation
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 6 more...
.ubiquitinated histone binding
.SMAD binding
.identical protein binding
  + 3 more...
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood16
bone13
brain10
connective tissue6
embryonic tissue14
esophagus49
eye28
heart11
intestine21
kidney9
liver4
lung29
lymph node22
mammary gland52
mouth181
ovary29
pancreas4
parathyroid48
pituitary gland60
placenta21
prostate15
salivary gland49
stomach125
testis18
thyroid42
uterus17
vascular19
Health State
TissuesTPM*
normal15
bladder carcinoma56
breast (mammary gland) tumor64
chondrosarcoma12
colorectal tumor35
esophageal tumor57
gastrointestinal tumor101
germ cell tumor11
glioma9
head and neck tumor104
leukemia42
liver tumor10
lung tumor29
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
retinoblastoma21
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult42
embryoid body28
blastocyst16
fetus26
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.8
adrenal gland16.1
appendix23.6
bone marrow26.6
cerebral cortex9.3
colon14.6
duodenum25.6
esophagus11.5
gallbladder25
heart muscle6.5
kidney16.3
liver15.5
lung28.1
lymph node31
ovary14
pancreas10.3
placenta12
prostate34.3
salivary gland20.9
skin17.1
small intestine21
spleen27.8
stomach29.1
testis22.7
thyroid gland16.4
urinary bladder16.3
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverHigh
lungMedium
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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