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> Protein (NX_Q2V2M9)
Protein (NX_Q2V2M9)
Protein
Gene SymbolFHOD3 to neXtProt (NX_Q2V2M9)
DescriptionFH1/FH2 domain-containing protein 3
Chromosome18
Location18q12.2 (33877677 ~ 34360018) to Ensembl
Sequene Features : Isoforms 4, Variants 227, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cardiac myofibril assembly
.actin filament network formation
.sarcomere organization
.negative regulation of actin filament polymerization
.N/A .Z disc
.striated muscle thin filament
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 227 2
2014-09-19protein level
4 183 2
2014-05-27protein level
4 183 2
2014-02-25protein level
4 181 2
2013-12-09protein level
4 148 2
2013-11-01protein level
4 143 2
2013-09-12protein level
4 143 2
2013-08-17protein level
4 143 2
2013-07-15protein level
4 98 2
2013-06-11protein level
4 98 2
2013-02-12protein level
4 55 14
2012-12-20protein level
4 55 14
2012-10-30protein level
3 55 9
2012-10-07protein level
3 55 3
2012-08-24protein level
3 52 3
2012-07-28protein level
3 52 3
2012-06-08protein level
3 60 3
2012-05-07protein level
3 36 3
2012-04-10protein level
3 36 3
2012-01-13protein level
3 19 3
2011-12-20protein level
3 19 3
2011-11-11protein level
3 19 3
2011-08-23protein level
3 19 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q2V2M9-1
0 57 0 158515.0784
NX_Q2V2M9-2
0 56 0 156655.2507
NX_Q2V2M9-3
0 57 0 160704.1293
NX_Q2V2M9-4
7 57 0 179969.0153
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-6395541,EBI-307104 SQSTM1  
  .activation of mitophagy in response to mitochondrial depolarization
.apoptotic signaling pathway
.protein heterooligomerization
  + 20 more...
.ubiquitin binding
.identical protein binding
.SH2 domain binding
  + 5 more...
.extracellular exosome
.cytoplasmic vesicle
.PML body
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
bone41
brain25
connective tissue26
embryonic tissue18
eye52
heart55
intestine21
kidney52
liver9
lung23
lymph node44
mouth30
muscle18
nerve128
ovary9
placenta3
prostate36
stomach20
testis22
trachea57
uterus8
Health State
TissuesTPM*
normal29
bladder carcinoma56
chondrosarcoma72
gastrointestinal tumor8
glioma27
head and neck tumor7
kidney tumor43
liver tumor20
lung tumor19
ovarian tumor13
retinoblastoma43
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult16
embryoid body14
blastocyst32
fetus30
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.3
adrenal gland30.6
appendix3.2
cerebral cortex10.3
colon4.2
duodenum1.9
esophagus13.3
gallbladder9.4
heart muscle110.9
kidney19.1
lung2.4
lymph node1.9
ovary7.5
pancreas1.3
placenta1.1
prostate31.1
salivary gland10.1
skin6
small intestine2.9
spleen1.5
stomach1.8
testis4.7
thyroid gland3.4
urinary bladder11
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*609691, gene) Formin homology-2 domain-containing protein 3; FHOD3OMIM


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