Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q3KNV8)
Protein (NX_Q3KNV8)
Protein
Gene SymbolPCGF3 to neXtProt (NX_Q3KNV8)
DescriptionPolycomb group RING finger protein 3
Chromosome4
Location4p16.3 (699537 ~ 764428) to Ensembl
Sequene Features : Isoforms 2, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.zinc ion binding .PcG protein complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 25 0
2014-09-19protein level
2 21 0
2014-05-27protein level
2 21 0
2014-02-25protein level
2 21 0
2013-12-09protein level
2 17 0
2013-11-01protein level
2 17 0
2013-09-12protein level
2 17 0
2013-08-17protein level
2 17 0
2013-07-15protein level
2 7 0
2013-06-11protein level
2 7 0
2013-02-12protein level
2 0 0
2012-12-20protein level
2 0 0
2012-10-30protein level
2 1 0
2012-10-07protein level
2 1 0
2012-08-24protein level
2 1 0
2012-07-28protein level
2 1 0
2012-06-08protein level
2 0 0
2012-05-07protein level
2 0 0
2012-04-10protein level
2 0 0
2012-01-13protein level
2 0 0
2011-12-20protein level
2 0 0
2011-11-11protein level
2 0 0
2011-08-23protein level
2 0 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q3KNV8-1
0 12 0 28097.1963
NX_Q3KNV8-2
0 12 0 28729.4939
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2339807,EBI-3951758 CBX6  
  .chromatin modification
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.single-stranded RNA binding .PcG protein complex
.nucleoplasm
.nucleus
.heterochromatin
2 EBI-2339807,EBI-3923843 CBX7  
  .sebaceous gland development
.chromatin modification
.transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.single-stranded RNA binding
.chromatin binding
.PRC1 complex
.PcG protein complex
.cytoplasm
  + 4 more...
3 EBI-2339807,EBI-752313 RING1  
  .camera-type eye morphogenesis
.negative regulation of transcription, DNA-templated
.cellular protein metabolic process
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.chromatin binding
.PRC1 complex
.PcG protein complex
.nuclear speck
  + 4 more...
4 EBI-2339807,EBI-10208579 BCOR  
  .negative regulation of tooth mineralization
.specification of axis polarity
.palate development
  + 9 more...
.transcription regulatory region DNA binding
.histone deacetylase binding
.heat shock protein binding
  + 2 more...
.nucleus
5 EBI-2339807,EBI-713786 PHC2  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 2 more...
.identical protein binding
.zinc ion binding
.DNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 2 more...
6 EBI-2339807,EBI-722416 RNF2  
  .cellular protein metabolic process
.post-translational protein modification
.negative regulation of sequence-specific DNA binding transcription factor activity
  + 8 more...
.RING-like zinc finger domain binding
.ligase activity
.zinc ion binding
  + 2 more...
.MLL1 complex
.PRC1 complex
.PcG protein complex
  + 6 more...
7 EBI-2339807,EBI-712912 CBX8  
  .cellular protein metabolic process
.post-translational protein modification
.protein sumoylation
  + 3 more...
.methylated histone binding
.ubiquitin-protein transferase activity
.single-stranded RNA binding
.PRC1 complex
.PcG protein complex
.nucleoplasm
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites100
bladder33
blood16
bone69
brain25
cervix41
connective tissue13
embryonic tissue37
esophagus198
eye9
heart11
intestine12
kidney71
larynx42
liver77
lung8
lymph135
lymph node11
mammary gland19
mouth15
muscle9
nerve193
ovary29
pancreas18
pituitary gland121
placenta14
prostate31
skin4
spleen18
stomach41
testis9
thymus87
trachea19
umbilical cord217
uterus17
vascular38
Health State
TissuesTPM*
normal25
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma24
colorectal tumor133
esophageal tumor231
gastrointestinal tumor50
germ cell tumor30
glioma37
head and neck tumor7
kidney tumor72
leukemia10
liver tumor52
lung tumor9
lymphoma83
non-neoplasia20
ovarian tumor26
pancreatic tumor76
primitive neuroectodermal tumor of the CNS23
prostate cancer19
retinoblastoma21
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor133
Developmental Stage
TissuesTPM*
adult12
embryoid body28
blastocyst81
neonate96
fetus17
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.5
adrenal gland32
appendix23.7
bone marrow31.8
cerebral cortex13.7
colon17.3
duodenum29.7
esophagus24.5
gallbladder25.4
heart muscle16
kidney12.9
liver7.7
lung22.2
lymph node26.5
ovary30.6
pancreas8.9
placenta28
prostate24.2
salivary gland17.7
skin63.7
small intestine28.5
spleen31.6
stomach24.2
testis22.4
thyroid gland17.7
urinary bladder26.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center