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> Protein (NX_Q494U1)
Protein (NX_Q494U1)
Protein
Gene SymbolPLEKHN1 to neXtProt (NX_Q494U1)
DescriptionPleckstrin homology domain-containing family N member 1
Chromosome1
Location1p36.33 (901877 ~ 911245) to Ensembl
Sequene Features : Isoforms 3, Variants 108, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 108 2
2014-09-19protein level
3 92 1
2014-05-27protein level
3 92 1
2014-02-25protein level
3 90 1
2013-12-09protein level
3 50 1
2013-11-01protein level
3 47 1
2013-09-12protein level
3 47 1
2013-08-17protein level
3 47 1
2013-07-15protein level
3 37 1
2013-06-11protein level
3 37 1
2013-02-12protein level
3 27 6
2012-12-20protein level
3 25 6
2012-10-30protein level
3 32 6
2012-10-07protein level
3 32 2
2012-08-24protein level
3 31 2
2012-07-28protein level
3 31 2
2012-06-08protein level
3 32 2
2012-05-07protein level
3 32 2
2012-04-10protein level
3 32 2
2012-01-13protein level
3 21 2
2011-12-20protein level
3 21 2
2011-11-11protein level
3 21 2
2011-08-23protein level
3 21 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q494U1-1
3 26 0 71745.108
NX_Q494U1-2
1 26 0 66367.5118
NX_Q494U1-3
1 25 0 62573.4244
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10241513,EBI-744222 LPXN  
  .negative regulation of B cell receptor signaling pathway
.regulation of cell adhesion mediated by integrin
.signal transduction
  + 5 more...
.zinc ion binding
.transcription cofactor activity
.perinuclear region of cytoplasm
.cell projection
.membrane
  + 5 more...
2 EBI-10241513,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-10241513,EBI-533224 TCF4  
  .protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
4 EBI-10241513,EBI-307352 REL  
  .negative regulation of neuron death
.positive regulation of transcription from RNA polymerase II promoter
.innate immune response
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II distal enhancer sequence-specific DNA binding
.I-kappaB/NF-kappaB complex
.cytosol
.transcription factor complex
  + 2 more...
5 EBI-10241513,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
6 EBI-10241513,EBI-10175039 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
7 EBI-10241513,EBI-529518 TAX1BP1  
  .innate immune response
.negative regulation of apoptotic process
.negative regulation of type I interferon production
  + 2 more...
.metal ion binding
.kinase binding
.extracellular exosome
.cytosol
8 EBI-10241513,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
9 EBI-10241513,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
10 EBI-10241513,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
embryonic tissue9
intestine4
lung2
mammary gland13
thyroid21
Health State
TissuesTPM*
breast (mammary gland) tumor21
head and neck tumor7
lung tumor9
Developmental Stage
TissuesTPM*
embryoid body14
blastocyst16
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
esophagus10.2
prostate1.2
skin25
stomach2.1
urinary bladder1.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastLow
bronchusLow
cerebellumLow
cerebral cortexMedium
colonMedium
duodenumLow
endometrium 1Low
epididymisLow
esophagusMedium
fallopian tubeLow
gallbladderMedium
kidneyLow
nasopharynxMedium
oral mucosaMedium
pancreasMedium
placentaLow
prostateLow
rectumLow
salivary glandLow
seminal vesicleLow
skin 1Low
skin 2Low
stomach 1Low
stomach 2Low
testisLow
tonsilLow
urinary bladderLow
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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