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	> Protein (NX_Q4VCS5) Protein (NX_Q4VCS5) Protein Gene Symbol AMOT to neXtProt (NX_Q4VCS5) Description Angiomotin Chromosome X Location Xq23 (112017731 ~ 112084043) to Ensembl Sequene Features : Isoforms 2, Variants 136, PTMs 7 to neXtProt Sequence Features Gene Ontologies GO: Biological Process GO: Mulecular Function GO: Cellular Component .positive regulation of stress fiber assembly .positive regulation of cell size .positive regulation of blood vessel endothelial cell migration   + 16 more... .angiostatin binding .receptor activity .endocytic vesicle .lamellipodium .integral component of membrane   + 8 more... Proteomic Evidences Release Protein Evidence Pr Ab Isoforms Variants PTMs 2015-01-01 protein level 2 136 7 2014-09-19 protein level 2 97 7 2014-05-27 protein level 2 97 7 2014-02-25 protein level 2 94 7 2013-12-09 protein level 2 75 7 2013-11-01 protein level 2 74 4 2013-09-12 protein level 2 74 5 2013-08-17 protein level 2 74 5 2013-07-15 protein level 2 51 5 2013-06-11 protein level 2 51 5 2013-02-12 protein level 2 20 12 2012-12-20 protein level 2 23 12 2012-10-30 protein level 2 28 12 2012-10-07 protein level 2 28 7 2012-08-24 protein level 2 21 7 2012-07-28 protein level 2 21 7 2012-06-08 protein level 2 21 7 2012-05-07 protein level 2 21 7 2012-04-10 protein level 2 21 7 2012-01-13 protein level 2 2 7 2011-12-20 protein level 2 2 7 2011-11-11 protein level 2 2 7 2011-08-23 protein level 2 2 7 Protein Isoforms Isoform Ac   U G S Mw (Da) NX_Q4VCS5-1 17 24 2 118012.3028 NX_Q4VCS5-2 0 24 1 72495.0698 : Uniquely mapped peptide : Gene-specific peptide : Shared peptide Interacting Partners No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component 1 EBI-3891843,EBI-749483 SNAPC5     .gene expression .transcription initiation from RNA polymerase III promoter .transcription from RNA polymerase III promoter .transcription from RNA polymerase II promoter .sequence-specific DNA binding transcription factor activity .nucleolus .nucleoplasm .nucleus 2 EBI-3891843,EBI-739566 KRT15     .activation of mitophagy in response to mitochondrial depolarization .epidermis development .scaffold protein binding .structural constituent of cytoskeleton .extracellular exosome .intermediate filament .nucleus 3 EBI-2511319,EBI-1014472 NF2     .regulation of neural precursor cell proliferation .regulation of protein localization to nucleus .lens fiber cell differentiation   + 22 more... .N/A .perinuclear region of cytoplasm .apical part of cell .ruffle membrane   + 13 more... 4 EBI-3891843,EBI-2798728 LMO4     .regulation of cell activation .thymus development .positive regulation of transcription from RNA polymerase II promoter   + 8 more... .zinc ion binding .transcription factor binding .sequence-specific DNA binding transcription factor activity .enhancer sequence-specific DNA binding .transcription factor complex 5 EBI-3891843,EBI-711260 UNC119     .negative regulation of caveolin-mediated endocytosis .negative regulation of clathrin-mediated endocytosis .positive regulation of protein tyrosine kinase activity   + 5 more... .lipid binding .spindle midzone .intercellular bridge .cytosol   + 2 more... 6 EBI-3891843,EBI-714158 PIN1     .negative regulation of cell motility .negative regulation of ERK1 and ERK2 cascade .regulation of pathway-restricted SMAD protein phosphorylation   + 11 more... .phosphothreonine binding .phosphoserine binding .GTPase activating protein binding   + 2 more... .midbody .nuclear speck .cytoplasm   + 2 more... 7 EBI-3891843,EBI-1774121 PPP2R4     .regulation of phosphoprotein phosphatase activity .positive regulation of apoptotic process .negative regulation of protein dephosphorylation   + 7 more... .protein phosphatase 2A binding .protein heterodimerization activity .protein homodimerization activity   + 5 more... .extracellular exosome .calcium channel complex .cytoplasm   + 3 more... 8 EBI-3891843,EBI-948001 KRT31     .epidermis development .structural constituent of cytoskeleton .extracellular exosome .intermediate filament .extracellular space 9 EBI-3891843,EBI-1642807 ARHGAP17     .regulation of small GTPase mediated signal transduction .small GTPase mediated signal transduction .GTPase activator activity .tight junction .plasma membrane .cytosol 10 EBI-3891843,EBI-747505 C1orf216     .N/A .N/A .N/A 11 EBI-3891843,EBI-693002 SEPT1     .cell division .cell cycle .GTP binding .midbody .microtubule organizing center .cytoplasm 12 EBI-3891843,EBI-741158 WDYHV1     .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol .nucleus 13 EBI-3891843,EBI-741355 LURAP1     .positive regulation of I-kappaB kinase/NF-kappaB signaling .actomyosin structure organization .cell migration .positive regulation of cytokine production .N/A .actomyosin .cytoplasm 14 EBI-3891843,EBI-394607 MED4     .positive regulation of transcription, DNA-templated .androgen receptor signaling pathway .intracellular steroid hormone receptor signaling pathway   + 3 more... .thyroid hormone receptor binding .vitamin D receptor binding .ligand-dependent nuclear receptor transcription coactivator activity   + 3 more... .mediator complex .membrane .nucleoplasm .nucleus EST expression level of Protein Coding Gene (ref. NCBI UniGene EST) Body Sites Tissues TPM* adrenal gland 30 brain 26 connective tissue 13 embryonic tissue 32 heart 89 intestine 25 kidney 61 lung 11 lymph node 11 mammary gland 26 mouth 90 muscle 56 ovary 49 pancreas 14 pituitary gland 60 placenta 56 prostate 36 skin 28 testis 32 thymus 12 thyroid 21 trachea 19 uterus 43 Health State Tissues TPM* normal 30 breast (mammary gland) tumor 42 chondrosarcoma 24 colorectal tumor 44 germ cell tumor 34 head and neck tumor 37 kidney tumor 87 non-neoplasia 51 ovarian tumor 52 pancreatic tumor 28 prostate cancer 19 skin tumor 47 uterine tumor 55 Developmental Stage Tissues TPM* adult 33 embryoid body 71 fetus 55 infant 42 TPM*: Transcripts per million; transcript expression level measured by expression sequence tags. Expression level of Protein (ref. Human Protein Atlas) RNA-Seq. Tissues FPKM adipose tissue 4.1 adrenal gland 2.3 appendix 2.2 cerebral cortex 15.8 colon 4.8 duodenum 4.6 esophagus 5.1 gallbladder 4.3 heart muscle 4.1 kidney 12.2 liver 1.7 lung 4.1 ovary 7.4 pancreas 1.4 placenta 27.2 prostate 10.9 salivary gland 3.4 skin 2.5 small intestine 4.7 spleen 1.9 stomach 5.2 testis 4 thyroid gland 4.9 urinary bladder 3.5 RNA-seq colour codes Highly expressed RNAs (FPKM >50) Moderately expressed RNAs (50> FPKM >10) Lower expressed RNAs (10> FPKM >1) The lowest expressed RNAs (FPKM value of 0 or 1) Disease No. Disease Description Ref. 1 (*300410, gene) Angiomotin; AMOT OMIM

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