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> Protein (NX_Q4VCS5)
Protein (NX_Q4VCS5)
Protein
Gene SymbolAMOT to neXtProt (NX_Q4VCS5)
DescriptionAngiomotin
ChromosomeX
LocationXq23 (112017731 ~ 112084043) to Ensembl
Sequene Features : Isoforms 2, Variants 136, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of stress fiber assembly
.positive regulation of cell size
.positive regulation of blood vessel endothelial cell migration
  + 16 more...
.angiostatin binding
.receptor activity
.endocytic vesicle
.lamellipodium
.integral component of membrane
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 136 7
2014-09-19protein level
2 97 7
2014-05-27protein level
2 97 7
2014-02-25protein level
2 94 7
2013-12-09protein level
2 75 7
2013-11-01protein level
2 74 4
2013-09-12protein level
2 74 5
2013-08-17protein level
2 74 5
2013-07-15protein level
2 51 5
2013-06-11protein level
2 51 5
2013-02-12protein level
2 20 12
2012-12-20protein level
2 23 12
2012-10-30protein level
2 28 12
2012-10-07protein level
2 28 7
2012-08-24protein level
2 21 7
2012-07-28protein level
2 21 7
2012-06-08protein level
2 21 7
2012-05-07protein level
2 21 7
2012-04-10protein level
2 21 7
2012-01-13protein level
2 2 7
2011-12-20protein level
2 2 7
2011-11-11protein level
2 2 7
2011-08-23protein level
2 2 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q4VCS5-1
17 24 2 118012.3028
NX_Q4VCS5-2
0 24 1 72495.0698
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3891843,EBI-749483 SNAPC5  
  .gene expression
.transcription initiation from RNA polymerase III promoter
.transcription from RNA polymerase III promoter
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity .nucleolus
.nucleoplasm
.nucleus
2 EBI-3891843,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-2511319,EBI-1014472 NF2  
  .regulation of neural precursor cell proliferation
.regulation of protein localization to nucleus
.lens fiber cell differentiation
  + 22 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.ruffle membrane
  + 13 more...
4 EBI-3891843,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
5 EBI-3891843,EBI-711260 UNC119  
  .negative regulation of caveolin-mediated endocytosis
.negative regulation of clathrin-mediated endocytosis
.positive regulation of protein tyrosine kinase activity
  + 5 more...
.lipid binding .spindle midzone
.intercellular bridge
.cytosol
  + 2 more...
6 EBI-3891843,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
7 EBI-3891843,EBI-1774121 PPP2R4  
  .regulation of phosphoprotein phosphatase activity
.positive regulation of apoptotic process
.negative regulation of protein dephosphorylation
  + 7 more...
.protein phosphatase 2A binding
.protein heterodimerization activity
.protein homodimerization activity
  + 5 more...
.extracellular exosome
.calcium channel complex
.cytoplasm
  + 3 more...
8 EBI-3891843,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
9 EBI-3891843,EBI-1642807 ARHGAP17  
  .regulation of small GTPase mediated signal transduction
.small GTPase mediated signal transduction
.GTPase activator activity .tight junction
.plasma membrane
.cytosol
10 EBI-3891843,EBI-747505 C1orf216  
  .N/A .N/A .N/A
11 EBI-3891843,EBI-693002 SEPT1  
  .cell division
.cell cycle
.GTP binding .midbody
.microtubule organizing center
.cytoplasm
12 EBI-3891843,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
13 EBI-3891843,EBI-741355 LURAP1  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.actomyosin structure organization
.cell migration
.positive regulation of cytokine production
.N/A .actomyosin
.cytoplasm
14 EBI-3891843,EBI-394607 MED4  
  .positive regulation of transcription, DNA-templated
.androgen receptor signaling pathway
.intracellular steroid hormone receptor signaling pathway
  + 3 more...
.thyroid hormone receptor binding
.vitamin D receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 3 more...
.mediator complex
.membrane
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
brain26
connective tissue13
embryonic tissue32
heart89
intestine25
kidney61
lung11
lymph node11
mammary gland26
mouth90
muscle56
ovary49
pancreas14
pituitary gland60
placenta56
prostate36
skin28
testis32
thymus12
thyroid21
trachea19
uterus43
Health State
TissuesTPM*
normal30
breast (mammary gland) tumor42
chondrosarcoma24
colorectal tumor44
germ cell tumor34
head and neck tumor37
kidney tumor87
non-neoplasia51
ovarian tumor52
pancreatic tumor28
prostate cancer19
skin tumor47
uterine tumor55
Developmental Stage
TissuesTPM*
adult33
embryoid body71
fetus55
infant42
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.1
adrenal gland2.3
appendix2.2
cerebral cortex15.8
colon4.8
duodenum4.6
esophagus5.1
gallbladder4.3
heart muscle4.1
kidney12.2
liver1.7
lung4.1
ovary7.4
pancreas1.4
placenta27.2
prostate10.9
salivary gland3.4
skin2.5
small intestine4.7
spleen1.9
stomach5.2
testis4
thyroid gland4.9
urinary bladder3.5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*300410, gene) Angiomotin; AMOTOMIM


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