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> Protein (NX_Q52MB2)
Protein (NX_Q52MB2)
Protein
Gene SymbolCCDC184 to neXtProt (NX_Q52MB2)
DescriptionCoiled-coil domain-containing protein 184
Chromosome12
Location12q13.11 (48577366 ~ 48579709) to Ensembl
Sequene Features : Isoforms 1, Variants 7, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .cytoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
1 7 0
2014-09-19transcript level
1 11 0
2014-05-27transcript level
1 11 0
2014-02-25transcript level
1 11 0
2013-12-09transcript level
1 8 0
2013-11-01transcript level
1 8 0
2013-09-12transcript level
1 8 0
2013-08-17transcript level
1 8 0
2013-07-15transcript level
1 5 0
2013-06-11transcript level
1 5 0
2013-02-12transcript level
1 4 0
2012-12-20transcript level
1 4 0
2012-10-30transcript level
1 5 0
2012-10-07transcript level
1 5 0
2012-08-24transcript level
1 5 0
2012-07-28transcript level
1 5 0
2012-06-08transcript level
1 6 0
2012-05-07transcript level
1 6 0
2012-04-10transcript level
1 6 0
2012-01-13transcript level
1 3 0
2011-12-20transcript level
1 3 0
2011-11-11transcript level
1 3 0
2011-08-23transcript level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q52MB2-1
9 0 0 20470.6297
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10179526,EBI-523498 TRAF5  
  .positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 4 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
  + 2 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
2 EBI-10179526,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
3 EBI-10179526,EBI-751540 GPANK1  
  .N/A .nucleic acid binding .N/A
4 EBI-10179526,EBI-750589 PBLD  
  .negative regulation of pathway-restricted SMAD protein phosphorylation
.negative regulation of SMAD protein import into nucleus
.negative regulation of epithelial cell proliferation
  + 5 more...
.isomerase activity .extracellular exosome
.cytoplasm
5 EBI-10179526,EBI-358122 RPL9  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.rRNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic large ribosomal subunit
.membrane
.focal adhesion
  + 5 more...
6 EBI-10179526,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
7 EBI-10179526,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
8 EBI-10179526,EBI-1105153 PPP1R13B  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
.N/A .plasma membrane
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
brain92
embryonic tissue4
eye19
intestine4
kidney14
liver4
lung2
mammary gland13
muscle9
pancreas9
placenta14
testis16
uterus8
Health State
TissuesTPM*
normal35
germ cell tumor49
kidney tumor43
liver tumor10
non-neoplasia10
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult16
embryoid body14
fetus95
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland4.9
cerebral cortex7.9
gallbladder1.4
ovary3.6
placenta1.8
testis2.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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