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> Protein (NX_Q53EP0)
Protein (NX_Q53EP0)
Protein
Gene SymbolFNDC3B to neXtProt (NX_Q53EP0)
DescriptionFibronectin type III domain-containing protein 3B
Chromosome3
Location3q26.31 (171757418 ~ 172119455) to Ensembl
Sequene Features : Isoforms 3, Variants 160, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .poly(A) RNA binding .integral component of membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 160 2
2014-09-19protein level
3 129 2
2014-05-27protein level
3 129 2
2014-02-25protein level
3 128 2
2013-12-09protein level
3 99 2
2013-11-01protein level
3 97 2
2013-09-12protein level
3 97 2
2013-08-17protein level
3 97 2
2013-07-15protein level
3 77 2
2013-06-11protein level
3 77 2
2013-02-12protein level
3 39 5
2012-12-20protein level
3 37 5
2012-10-30protein level
3 44 5
2012-10-07protein level
3 44 3
2012-08-24protein level
3 40 3
2012-07-28protein level
3 40 3
2012-06-08protein level
3 53 3
2012-05-07protein level
3 39 3
2012-04-10protein level
3 39 3
2012-01-13protein level
3 35 3
2011-12-20protein level
3 35 3
2011-11-11protein level
3 35 3
2011-08-23protein level
3 35 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q53EP0-1
22 26 0 132802.8684
NX_Q53EP0-2
1 26 0 69527.1034
NX_Q53EP0-3
1 1 0 7838.8115
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10242151,EBI-948613 TOX4  
  .regulation of transcription, DNA-templated
.chromatin remodeling
.chromatin binding
.DNA binding
.PTW/PP1 phosphatase complex
.nucleoplasm
.chromatin
2 EBI-10242151,EBI-2107455 VAC14  
  .small molecule metabolic process
.regulation of lipid kinase activity
.viral process
  + 3 more...
.receptor activity .PAS complex
.late endosome membrane
.early endosome membrane
  + 3 more...
3 EBI-10242151,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
4 EBI-10242151,EBI-351018 CAMK2D  
  .negative regulation of sodium ion transmembrane transporter activity
.regulation of generation of L-type calcium current
.negative regulation of sodium ion transmembrane transport
  + 41 more...
.ion channel binding
.protein homodimerization activity
.titin binding
  + 5 more...
.perinuclear region of cytoplasm
.axon initial segment
.neuronal cell body
  + 12 more...
5 EBI-10242151,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland91
ascites25
blood40
bone153
bone marrow61
brain13
cervix61
connective tissue80
ear248
embryonic tissue51
esophagus49
eye19
heart178
intestine64
kidney66
larynx42
liver63
lung65
lymph node22
mammary gland178
mouth15
muscle28
ovary49
pancreas74
placenta155
prostate15
salivary gland49
skin75
spleen37
stomach52
testis18
thymus12
thyroid107
trachea77
uterus94
vascular116
Health State
TissuesTPM*
normal74
adrenal tumor158
breast (mammary gland) tumor107
cervical tumor86
chondrosarcoma108
colorectal tumor88
esophageal tumor57
gastrointestinal tumor33
germ cell tumor26
glioma27
head and neck tumor29
kidney tumor58
leukemia31
liver tumor83
lung tumor38
non-neoplasia31
ovarian tumor52
pancreatic tumor47
primitive neuroectodermal tumor of the CNS7
prostate cancer28
skin tumor79
soft tissue/muscle tissue tumor23
uterine tumor166
Developmental Stage
TissuesTPM*
adult74
embryoid body100
blastocyst32
neonate64
fetus96
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue45.7
adrenal gland27.5
appendix29.3
bone marrow36.4
cerebral cortex5.3
colon22.5
duodenum17
esophagus16.2
gallbladder43.9
heart muscle29.6
kidney21.2
liver19.8
lung29.1
lymph node12.4
ovary29
pancreas16.2
placenta55.3
prostate14.9
salivary gland18.4
skin6
small intestine13.4
spleen20.3
stomach23
testis12
thyroid gland66.8
urinary bladder64.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611909, gene) Fibronectin domain iii-containing protein 3b; FNDC3BOMIM


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