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> Protein (NX_Q53FD0)
Protein (NX_Q53FD0)
Protein
Gene SymbolZC2HC1C to neXtProt (NX_Q53FD0)
DescriptionZinc finger C2HC domain-containing protein 1C
Chromosome14
Location14q24.3 (75530873 ~ 75545126) to Ensembl
Sequene Features : Isoforms 2, Variants 29, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .metal ion binding .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 29 1
2014-09-19protein level
2 43 1
2014-05-27protein level
2 43 1
2014-02-25protein level
2 43 1
2013-12-09protein level
2 25 1
2013-11-01protein level
2 25 1
2013-09-12protein level
2 25 1
2013-08-17protein level
2 25 1
2013-07-15protein level
2 18 1
2013-06-11protein level
2 18 1
2013-02-12transcript level
2 13 0
2012-12-20transcript level
2 8 0
2012-10-30transcript level
2 19 0
2012-10-07transcript level
2 19 0
2012-08-24transcript level
2 19 0
2012-07-28transcript level
2 19 0
2012-06-08transcript level
2 21 0
2012-05-07transcript level
2 18 0
2012-04-10transcript level
1 11 0
2012-01-13transcript level
1 3 0
2011-12-20transcript level
1 3 0
2011-11-11transcript level
1 3 0
2011-08-23transcript level
1 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q53FD0-1
6 9 0 51625.7931
NX_Q53FD0-2
0 9 0 31029.7347
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740767,EBI-5661036 FSD2  
  .N/A .N/A .N/A
2 EBI-740767,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
3 EBI-740767,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-740767,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
5 EBI-740767,EBI-476295 SFN  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 20 more...
.protein kinase C inhibitor activity .extracellular exosome
.cytoplasmic vesicle membrane
.cytosol
  + 3 more...
6 EBI-740767,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
7 EBI-740767,EBI-355744 TRAF2  
  .positive regulation of extrinsic apoptotic signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.negative regulation of neuron death
  + 35 more...
.sphingolipid binding
.identical protein binding
.thioesterase binding
  + 10 more...
.IRE1-TRAF2-ASK1 complex
.TRAF2-GSTP1 complex
.membrane raft
  + 7 more...
8 EBI-740767,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
9 EBI-740767,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
10 EBI-740767,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
11 EBI-740767,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
12 EBI-740767,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
13 EBI-740767,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
14 EBI-740767,EBI-743290 HOOK2  
  .early endosome to late endosome transport
.protein transport
.endosome to lysosome transport
  + 3 more...
.identical protein binding .FHF complex
.microtubule
.centrosome
15 EBI-740767,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
16 EBI-740767,EBI-413317 SPAG5  
  .regulation of attachment of spindle microtubules to kinetochore
.cell division
.chromosome segregation
  + 2 more...
.N/A .mitotic spindle
.microtubule plus-end
.midbody
  + 7 more...
17 EBI-740767,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
18 EBI-740767,EBI-913954 RABGEF1  
  .negative regulation of Kit signaling pathway
.negative regulation of interleukin-6 secretion
.regulation of Fc receptor mediated stimulatory signaling pathway
  + 9 more...
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.zinc ion binding
  + 2 more...
.recycling endosome
.vesicle
.early endosome
19 EBI-740767,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
20 EBI-740767,EBI-744586 EMILIN1  
  .extracellular matrix organization
.positive regulation of cell-substrate adhesion
.cell adhesion
.extracellular matrix constituent conferring elasticity .extracellular exosome
.extracellular matrix
.collagen trimer
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
brain12
connective tissue6
eye14
intestine4
lung8
lymph67
mouth15
muscle9
pharynx24
placenta3
skin9
testis206
thyroid21
trachea19
uterus25
Health State
TissuesTPM*
normal19
germ cell tumor3
head and neck tumor14
leukemia21
lymphoma41
non-neoplasia20
skin tumor15
soft tissue/muscle tissue tumor7
uterine tumor66
Developmental Stage
TissuesTPM*
adult8
fetus8
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1.1
adrenal gland3
appendix1.6
cerebral cortex2.2
colon3
duodenum3.3
esophagus1.8
gallbladder3
heart muscle3.6
kidney6.4
liver8.8
lung3.9
pancreas3.1
placenta2.5
prostate1.6
salivary gland2.7
small intestine3.5
stomach2.3
testis66.7
thyroid gland7.4
urinary bladder1.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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