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> Protein (NX_Q53G59)
Protein (NX_Q53G59)
Protein
Gene SymbolKLHL12 to neXtProt (NX_Q53G59)
DescriptionKelch-like protein 12
Chromosome1
Location1q32.1 (202860228 ~ 202897764) to Ensembl
Sequene Features : Isoforms 2, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
.Wnt signaling pathway
  + 2 more...
.N/A .Cul3-RING ubiquitin ligase complex
.ER to Golgi transport vesicle
.cytosol
.Golgi membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 60 0
2014-09-19protein level
2 45 0
2014-05-27protein level
2 45 0
2014-02-25protein level
2 44 0
2013-12-09protein level
2 34 0
2013-11-01protein level
2 32 0
2013-09-12protein level
2 32 0
2013-08-17protein level
2 32 0
2013-07-15protein level
2 19 0
2013-06-11protein level
2 19 0
2013-02-12protein level
2 7 4
2012-12-20protein level
2 8 4
2012-10-30protein level
2 12 4
2012-10-07protein level
2 12 2
2012-08-24protein level
2 9 2
2012-07-28protein level
2 9 2
2012-06-08protein level
2 13 2
2012-05-07protein level
2 12 2
2012-04-10protein level
2 12 2
2012-01-13protein level
1 8 2
2011-12-20protein level
1 8 2
2011-11-11protein level
1 8 2
2011-08-23protein level
1 8 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q53G59-1
1 26 0 63236.1673
NX_Q53G59-2
2 26 0 67683.4311
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-740929,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-740929,EBI-10191038 INMT  
  .methylation
.response to toxic substance
.amine metabolic process
.amine N-methyltransferase activity
.thioether S-methyltransferase activity
.cytosol
3 EBI-740929,EBI-641237 PDGFRB  
  .positive regulation of DNA biosynthetic process
.positive regulation of reactive oxygen species metabolic process
.positive regulation of calcium ion import
  + 60 more...
.platelet-derived growth factor binding
.vascular endothelial growth factor binding
.protein kinase binding
  + 7 more...
.extracellular exosome
.lysosomal lumen
.intrinsic component of plasma membrane
  + 9 more...
4 EBI-740929,EBI-9641086 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
5 EBI-740929,EBI-347552 BAG6  
  .tail-anchored membrane protein insertion into ER membrane
.intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
.protein stabilization
  + 17 more...
.proteasome binding
.ribosome binding
.ubiquitin protein ligase binding
.polyubiquitin binding
.BAT3 complex
.intracellular membrane-bounded organelle
.cytosol
  + 3 more...
6 EBI-740929,EBI-930964 ATXN1  
  .regulation of excitatory postsynaptic membrane potential
.nuclear export
.lung alveolus development
  + 9 more...
.protein self-association
.identical protein binding
.poly(G) binding
  + 4 more...
.intracellular membrane-bounded organelle
.nuclear inclusion body
.nuclear matrix
  + 3 more...
7 EBI-740929,EBI-711788 MPP1  
  .regulation of neutrophil chemotaxis
.nucleotide phosphorylation
.signal transduction
.guanylate kinase activity .stereocilium
.cortical cytoskeleton
.membrane
  + 2 more...
8 EBI-740929,EBI-456129 CUL3  
  .intrinsic apoptotic signaling pathway
.negative regulation of canonical Wnt signaling pathway
.COPII vesicle coating
  + 22 more...
.POZ domain binding .extracellular exosome
.Cul3-RING ubiquitin ligase complex
.membrane
  + 4 more...
9 EBI-740929,EBI-1050303 TTBK2  
  .cilium assembly
.peptidyl-serine phosphorylation
.regulation of cell shape
  + 2 more...
.ATP binding
.protein serine/threonine kinase activity
.ciliary basal body
.ciliary transition zone
.cytosol
  + 3 more...
10 EBI-740929,EBI-3923278 CCBE1  
  .positive regulation of lymphangiogenesis
.positive regulation of vascular endothelial growth factor signaling pathway
.venous blood vessel morphogenesis
  + 6 more...
.collagen binding
.calcium ion binding
.protease binding
.extracellular space
.collagen trimer
.proteinaceous extracellular matrix
11 EBI-740929,EBI-744896 SNX20  
  .protein transport .phosphatidylinositol binding .endosome membrane
.plasma membrane
.nucleus
12 EBI-740929,EBI-1057190 FGD2  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.metal ion binding
.small GTPase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.ruffle membrane
.early endosome membrane
.lamellipodium
  + 6 more...
13 EBI-740929,EBI-723524 MRPL10  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 4 more...
.poly(A) RNA binding
.structural constituent of ribosome
.ribonucleoprotein complex
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
  + 2 more...
14 EBI-740929,EBI-10261452 TBC1D10C  
  .negative regulation of ERK1 and ERK2 cascade
.negative regulation of NFAT protein import into nucleus
.negative regulation of B cell activation
.retrograde transport, endosome to Golgi
.GTPase activator activity .filopodium membrane
.membrane
.plasma membrane
15 EBI-740929,EBI-748515 GLYCTK  
  .protein phosphorylation .glycerate kinase activity
.ATP binding
.mitochondrion
.cytoplasm
16 EBI-740929,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
17 EBI-740929,EBI-10189722 RPP25L  
  .N/A .poly(A) RNA binding .nucleus
18 EBI-740929,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
19 EBI-740929,EBI-2817707 C1QTNF2  
  .protein heterotrimerization
.protein homooligomerization
.positive regulation of glucose import
  + 3 more...
.N/A .extracellular space
.collagen trimer
20 EBI-740929,EBI-740924 PRR13  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .nucleus
21 EBI-740929,EBI-724639 PEF1  
  .response to calcium ion
.proteolysis
.protein dimerization activity
.protein heterodimerization activity
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland30
ascites125
blood32
bone27
brain63
connective tissue80
ear62
embryonic tissue42
eye52
heart11
intestine43
kidney33
liver38
lung80
lymph67
lymph node77
mammary gland92
mouth136
muscle37
nerve64
pancreas37
parathyroid48
pharynx24
placenta52
prostate21
skin52
spleen37
stomach135
testis170
thymus12
thyroid107
trachea154
uterus38
vascular58
Health State
TissuesTPM*
normal64
breast (mammary gland) tumor75
chondrosarcoma60
colorectal tumor35
gastrointestinal tumor126
germ cell tumor129
glioma27
head and neck tumor82
kidney tumor58
leukemia74
liver tumor62
lung tumor136
lymphoma138
non-neoplasia82
pancreatic tumor28
primitive neuroectodermal tumor of the CNS7
prostate cancer19
retinoblastoma21
skin tumor23
soft tissue/muscle tissue tumor47
uterine tumor22
Developmental Stage
TissuesTPM*
adult58
embryoid body28
blastocyst97
neonate64
fetus78
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue9.1
adrenal gland13.5
appendix12.6
bone marrow9.1
cerebral cortex15.3
colon15.4
duodenum11
esophagus11.7
gallbladder10.6
heart muscle13
kidney14.7
liver6.4
lung11
lymph node14.9
ovary13.4
pancreas5.7
placenta10
prostate14.2
salivary gland8.2
skin9.2
small intestine11
spleen12.2
stomach11.7
testis36
thyroid gland14.9
urinary bladder12.6
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*614522, gene) Kelch-like 12; KLHL12OMIM


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