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> Protein (NX_Q53TN4)
Protein (NX_Q53TN4)
Protein
Gene SymbolCYBRD1 to neXtProt (NX_Q53TN4)
DescriptionCytochrome b reductase 1
Chromosome2
Location2q31.1 (172378757 ~ 172414643) to Ensembl
Sequene Features : Isoforms 3, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.transmembrane transport
.response to iron ion
.cellular iron ion homeostasis
.metal ion binding
.oxidoreductase activity, oxidizing metal ions
.ferric-chelate reductase activity
.extracellular exosome
.brush border membrane
.integral component of membrane
.plasma membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 48 4
2014-09-19protein level
3 35 4
2014-05-27protein level
3 33 4
2014-02-25protein level
3 33 4
2013-12-09protein level
3 18 4
2013-11-01protein level
3 18 4
2013-09-12protein level
3 18 4
2013-08-17protein level
3 18 4
2013-07-15protein level
3 13 4
2013-06-11protein level
3 13 4
2013-02-12protein level
3 9 6
2012-12-20protein level
2 9 3
2012-10-30protein level
2 11 3
2012-10-07protein level
2 11 3
2012-08-24protein level
2 11 3
2012-07-28protein level
2 11 3
2012-06-08protein level
2 12 3
2012-05-07protein level
2 9 3
2012-04-10protein level
2 9 3
2012-01-13protein level
2 5 3
2011-12-20protein level
2 5 3
2011-11-11protein level
2 5 3
2011-08-23protein level
1 5 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q53TN4-1
1 9 0 31620.6314
NX_Q53TN4-2
6 2 0 17891.5899
NX_Q53TN4-3
1 7 0 25071.146
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-8637742,EBI-744942 STX4  
  .positive regulation of protein localization to cell surface
.positive regulation of protein localization to plasma membrane
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 21 more...
.sphingomyelin phosphodiesterase activator activity
.SNAP receptor activity
.SNARE binding
.extracellular exosome
.perinuclear region of cytoplasm
.synapse
  + 19 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue854
adrenal gland91
bladder66
blood24
bone97
bone marrow41
brain79
connective tissue288
ear372
embryonic tissue28
esophagus148
eye81
heart111
intestine64
kidney56
liver38
lung68
lymph22
lymph node11
mammary gland85
mouth136
muscle37
nerve386
ovary68
pancreas37
parathyroid48
placenta38
prostate42
salivary gland49
skin99
spleen18
stomach83
testis87
thymus150
thyroid107
trachea2008
umbilical cord72
uterus409
vascular193
Health State
TissuesTPM*
normal85
adrenal tumor237
bladder carcinoma113
breast (mammary gland) tumor118
chondrosarcoma205
colorectal tumor44
esophageal tumor173
gastrointestinal tumor16
germ cell tumor72
glioma65
head and neck tumor74
kidney tumor87
leukemia42
liver tumor52
lung tumor9
lymphoma27
non-neoplasia217
ovarian tumor78
pancreatic tumor66
prostate cancer28
skin tumor15
soft tissue/muscle tissue tumor23
uterine tumor44
Developmental Stage
TissuesTPM*
adult69
blastocyst16
neonate96
fetus89
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue115.8
adrenal gland96.7
appendix25.8
bone marrow13
cerebral cortex15.6
colon46.7
duodenum173.5
esophagus70.2
gallbladder160.2
heart muscle62.3
kidney25.8
liver12.3
lung118.8
lymph node32.6
ovary166.5
pancreas10.4
placenta30.6
prostate58.7
salivary gland30.7
skin70.4
small intestine203.8
spleen24.6
stomach34.1
testis28.4
thyroid gland213.1
urinary bladder84.1
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605745, gene) Cytochrome b reductase 1; CYBRD1OMIM


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