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> Protein (NX_Q53TS8)
Protein (NX_Q53TS8)
Protein
Gene SymbolALS2CR11 to neXtProt (NX_Q53TS8)
DescriptionAmyotrophic lateral sclerosis 2 chromosomal region candidate gene 11 protein
Chromosome2
Location2q33.1 (202352148 ~ 202483901) to Ensembl
Sequene Features : Isoforms 4, Variants 156, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
4 156 0
2014-09-19transcript level
4 132 0
2014-05-27transcript level
4 132 0
2014-02-25transcript level
4 132 0
2013-12-09transcript level
4 104 0
2013-11-01transcript level
4 100 0
2013-09-12transcript level
4 100 0
2013-08-17transcript level
4 100 0
2013-07-15transcript level
4 58 0
2013-06-11transcript level
4 58 0
2013-02-12transcript level
2 32 0
2012-12-20transcript level
2 30 0
2012-10-30transcript level
2 39 0
2012-10-07transcript level
2 39 0
2012-08-24transcript level
2 29 0
2012-07-28transcript level
2 29 0
2012-06-08transcript level
2 29 0
2012-05-07transcript level
2 29 0
2012-04-10transcript level
2 29 0
2012-01-13transcript level
2 13 0
2011-12-20transcript level
2 13 0
2011-11-11transcript level
2 13 0
2011-08-23transcript level
2 13 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q53TS8-1
0 30 0 71113.7087
NX_Q53TS8-2
1 17 0 45198.0004
NX_Q53TS8-3
3 23 0 62371.5117
NX_Q53TS8-4
59 30 0 208925.6164
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-739879,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
2 EBI-739879,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
3 EBI-739879,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-739879,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
5 EBI-739879,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
6 EBI-739879,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
7 EBI-739879,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
8 EBI-739879,EBI-3952284 DNAJA3  
  .skeletal muscle acetylcholine-gated channel clustering
.negative regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 23 more...
.chaperone binding
.unfolded protein binding
.NF-kappaB binding
  + 5 more...
.postsynaptic membrane
.intracellular membrane-bounded organelle
.mitochondrial nucleoid
  + 8 more...
9 EBI-739879,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
10 EBI-739879,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
11 EBI-739879,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone marrow20
brain4
muscle18
nerve64
prostate5
testis135
Health State
TissuesTPM*
normal11
germ cell tumor3
Developmental Stage
TissuesTPM*
adult4
fetus7
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
testis39.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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