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> Protein (NX_Q58A45)
Protein (NX_Q58A45)
Protein
Gene SymbolPAN3 to neXtProt (NX_Q58A45)
DescriptionPAB-dependent poly(A)-specific ribonuclease subunit PAN3
Chromosome13
Location13q12.2 (28712643 ~ 28869475) to Ensembl
Sequene Features : Isoforms 4, Variants 73, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of cytoplasmic mRNA processing body assembly
.gene expression
  + 4 more...
.metal ion binding
.transferase activity, transferring phosphorus-containing groups
.ATP binding
.PAN complex
.cytosol
.cytoplasmic mRNA processing body
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 73 3
2014-09-19protein level
4 48 3
2014-05-27protein level
4 48 3
2014-02-25protein level
4 48 3
2013-12-09protein level
4 45 3
2013-11-01protein level
4 43 3
2013-09-12protein level
4 43 3
2013-08-17protein level
4 43 3
2013-07-15protein level
4 30 2
2013-06-11protein level
4 30 2
2013-02-12protein level
4 13 0
2012-12-20protein level
4 14 0
2012-10-30protein level
4 15 0
2012-10-07protein level
4 15 0
2012-08-24protein level
4 13 0
2012-07-28protein level
4 13 0
2012-06-08protein level
4 18 0
2012-05-07protein level
4 10 0
2012-04-10protein level
4 10 0
2012-01-13protein level
4 5 0
2011-12-20protein level
4 5 0
2011-11-11protein level
4 5 0
2011-08-23protein level
4 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q58A45-1
0 36 0 95551.9034
NX_Q58A45-2
2 27 0 64423.5656
NX_Q58A45-3
1 33 0 89347.6685
NX_Q58A45-4
1 23 0 72886.1821
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2513054,EBI-81531 PABPC1  
  .negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
2 EBI-2513054,EBI-1058976 PAN2  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of cytoplasmic mRNA processing body assembly
.gene expression
  + 2 more...
.poly(A)-specific ribonuclease activity
.nucleic acid binding
.3'-5'-exoribonuclease activity
.PAN complex
.cytosol
.nucleus
.cytoplasmic mRNA processing body
3 EBI-2513054,EBI-2269715 TNRC6A  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.innate immune response
  + 9 more...
.poly(A) RNA binding
.nucleotide binding
.micro-ribonucleoprotein complex
.cytosol
.nucleoplasm
.cytoplasmic mRNA processing body
4 EBI-2513054,EBI-6507625 TNRC6C  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.regulation of gene silencing by miRNA
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 13 more...
.RNA binding
.nucleotide binding
.cytosol
5 EBI-2513054,EBI-947158 TNRC6B  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.phosphatidylinositol-mediated signaling
  + 10 more...
.poly(A) RNA binding
.nucleotide binding
.cytosol
.cytoplasmic mRNA processing body
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood57
bone marrow20
brain18
cervix20
connective tissue20
ear186
embryonic tissue32
eye23
intestine21
kidney14
liver4
lung26
lymph node100
mammary gland59
muscle37
nerve64
ovary19
pituitary gland121
placenta49
prostate26
skin14
spleen18
stomach62
testis29
trachea57
uterus30
vascular19
Health State
TissuesTPM*
normal28
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor42
germ cell tumor37
glioma9
kidney tumor14
leukemia10
liver tumor10
lymphoma27
non-neoplasia31
ovarian tumor13
prostate cancer19
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult30
embryoid body42
blastocyst32
neonate32
fetus43
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue11.9
adrenal gland11.9
appendix17.2
bone marrow20.9
cerebral cortex7.4
colon12.5
duodenum10.6
esophagus12.2
gallbladder14.9
heart muscle5.1
kidney12.4
liver5.1
lung14.6
lymph node24.6
ovary15.1
pancreas7.3
placenta12.6
prostate15.3
salivary gland10.2
skin19.4
small intestine11.5
spleen22.4
stomach13.4
testis18.4
thyroid gland17.2
urinary bladder14
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
breastLow
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineLow
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeHigh
nasopharynxMedium
ovaryLow
pancreasMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilHigh
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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