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> Protein (NX_Q59EK9)
Protein (NX_Q59EK9)
Protein
Gene SymbolRUNDC3A to neXtProt (NX_Q59EK9)
DescriptionRUN domain-containing protein 3A
Chromosome17
Location17q21.31 (42385781 ~ 42396039) to Ensembl
Sequene Features : Isoforms 4, Variants 25, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small GTPase mediated signal transduction .GTPase regulator activity
.guanylate cyclase activator activity
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 25 0
2014-09-19protein level
4 16 0
2014-05-27protein level
4 16 0
2014-02-25protein level
4 16 0
2013-12-09protein level
4 16 0
2013-11-01protein level
4 16 0
2013-09-12protein level
4 16 0
2013-08-17protein level
4 16 0
2013-07-15protein level
4 10 0
2013-06-11protein level
4 10 0
2013-02-12transcript level
4 7 0
2012-12-20transcript level
4 5 0
2012-10-30transcript level
4 6 0
2012-10-07transcript level
4 6 0
2012-08-24transcript level
4 6 0
2012-07-28transcript level
4 6 0
2012-06-08transcript level
4 7 0
2012-05-07transcript level
4 5 0
2012-04-10transcript level
4 5 0
2012-01-13transcript level
4 3 0
2011-12-20transcript level
4 3 0
2011-11-11transcript level
4 3 0
2011-08-23transcript level
4 3 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q59EK9-1
3 15 0 49715.6525
NX_Q59EK9-2
1 15 0 45240.5093
NX_Q59EK9-3
0 16 0 45653.6815
NX_Q59EK9-4
0 14 0 41297.742
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747225,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
2 EBI-747225,EBI-751857 MAGEB4  
  .N/A .N/A .N/A
3 EBI-747225,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
4 EBI-747225,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
5 EBI-747225,EBI-347740 EIF3E  
  .negative regulation of translational initiation
.cellular protein metabolic process
.gene expression
  + 5 more...
.protein N-terminus binding
.poly(A) RNA binding
.translation initiation factor activity
.extracellular exosome
.eukaryotic 48S preinitiation complex
.PML body
  + 7 more...
6 EBI-747225,EBI-750871 RAP2B  
  .platelet aggregation
.regulation of protein tyrosine kinase activity
.Rap protein signal transduction
  + 4 more...
.GDP binding
.GTP binding
.extracellular exosome
.recycling endosome membrane
.membrane raft
  + 5 more...
7 EBI-747225,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
8 EBI-747225,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
9 EBI-747225,EBI-746778 MAGOHB  
  .mRNA transport
.RNA splicing
.mRNA processing
.poly(A) RNA binding .catalytic step 2 spliceosome
.exon-exon junction complex
10 EBI-747225,EBI-1045974 CCNL2  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.regulation of cyclin-dependent protein serine/threonine kinase activity
.N/A .intracellular membrane-bounded organelle
.cell junction
.nuclear speck
  + 3 more...
11 EBI-747225,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
12 EBI-747225,EBI-745392 SYT17  
  .positive regulation of dendrite extension
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.clathrin binding
.syntaxin binding
.calcium-dependent phospholipid binding
.calcium ion binding
.plasma membrane
.trans-Golgi network
13 EBI-747225,EBI-541426 AP1M1  
  .membrane organization
.regulation of defense response to virus by virus
.endosome to melanosome transport
  + 5 more...
.N/A .extracellular exosome
.trans-Golgi network membrane
.clathrin-coated endocytic vesicle membrane
  + 6 more...
14 EBI-747225,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
15 EBI-747225,EBI-2371967 MRPL15  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 2 more...
.poly(A) RNA binding
.structural constituent of ribosome
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain120
embryonic tissue4
eye38
heart22
kidney4
lung23
muscle9
nerve64
pancreas42
pituitary gland242
prostate5
skin4
spleen37
testis6
Health State
TissuesTPM*
normal39
bladder carcinoma56
germ cell tumor22
glioma214
kidney tumor14
lung tumor29
non-neoplasia20
pancreatic tumor38
primitive neuroectodermal tumor of the CNS86
retinoblastoma64
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult25
embryoid body14
fetus44
infant42
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland20.1
bone marrow2.6
cerebral cortex111.4
colon1.1
duodenum1.7
kidney1.1
pancreas2.3
placenta2
skin6.8
small intestine1.5
stomach3.4
testis8.5
thyroid gland2.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*605448, gene) Run domain-containing 3a; RUNDC3AOMIM


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