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> Protein (NX_Q5D1E8)
Protein (NX_Q5D1E8)
Protein
Gene SymbolZC3H12A to neXtProt (NX_Q5D1E8)
DescriptionRibonuclease ZC3H12A
Chromosome1
Location1p34.3 (37940153 ~ 37949980) to Ensembl
Sequene Features : Isoforms 1, Variants 82, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of reactive oxygen species metabolic process
.cellular response to lipopolysaccharide
.positive regulation of fat cell differentiation
  + 12 more...
.metal ion binding
.endonuclease activity
.plasma membrane
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 82 0
2014-09-19protein level
1 66 0
2014-05-27protein level
1 66 0
2014-02-25protein level
1 66 0
2013-12-09protein level
1 51 0
2013-11-01protein level
1 50 0
2013-09-12protein level
1 50 0
2013-08-17protein level
1 50 0
2013-07-15protein level
1 29 0
2013-06-11protein level
1 29 0
2013-02-12protein level
1 17 1
2012-12-20protein level
1 17 1
2012-10-30protein level
1 21 1
2012-10-07protein level
1 21 1
2012-08-24protein level
1 21 1
2012-07-28protein level
1 21 1
2012-06-08protein level
1 23 1
2012-05-07protein level
1 18 1
2012-04-10protein level
1 18 1
2012-01-13protein level
1 15 1
2011-12-20protein level
1 15 1
2011-11-11protein level
1 15 1
2011-08-23protein level
1 15 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5D1E8-1
25 0 4 65657.7417
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-747793,EBI-447733 IRAK2  
  .response to interleukin-1
.interleukin-1-mediated signaling pathway
.nucleotide-binding oligomerization domain containing signaling pathway
  + 25 more...
.protein heterodimerization activity
.protein homodimerization activity
.ATP binding
.protein serine/threonine kinase activity
.interleukin-1 receptor complex
.endosome membrane
.plasma membrane
  + 3 more...
2 EBI-747793,EBI-347161 SMAD3  
  .positive regulation of extracellular matrix assembly
.activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 73 more...
.R-SMAD binding
.co-SMAD binding
.transcription regulatory region DNA binding
  + 21 more...
.SMAD2-SMAD3 protein complex
.SMAD protein complex
.receptor complex
  + 8 more...
3 EBI-747793,EBI-2510389 USP10  
  .regulation of proteasomal protein catabolic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
.DNA damage response, signal transduction by p53 class mediator
  + 5 more...
.poly(A) RNA binding
.ion channel binding
.ubiquitin-specific protease activity
  + 2 more...
.early endosome
.cytoplasm
.nucleoplasm
.nucleus
4 EBI-747793,EBI-10181968 P4HA3  
  .N/A .L-ascorbic acid binding
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
.iron ion binding
.procollagen-proline 4-dioxygenase activity
.endoplasmic reticulum lumen
5 EBI-747793,EBI-720250 AHSP  
  .protein stabilization
.hemopoiesis
.hemoglobin metabolic process
.protein folding
.unfolded protein binding
.hemoglobin binding
.hemoglobin complex
6 EBI-747793,EBI-307461 BTRC  
  .cellular response to organic cyclic compound
.regulation of proteasomal protein catabolic process
.branching involved in mammary gland duct morphogenesis
  + 28 more...
.ligase activity
.ubiquitin-protein transferase activity
.SCF ubiquitin ligase complex
.cytosol
.nucleoplasm
7 EBI-747793,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder66
brain4
cervix82
connective tissue13
embryonic tissue18
esophagus148
eye19
heart11
intestine34
kidney14
liver19
lung98
lymph node33
mammary gland26
mouth90
muscle28
nerve64
ovary59
pancreas18
parathyroid48
pharynx171
placenta17
prostate36
skin23
spleen149
stomach41
testis18
thymus37
trachea135
uterus51
vascular38
Health State
TissuesTPM*
normal26
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor86
chondrosarcoma24
esophageal tumor115
gastrointestinal tumor16
germ cell tumor41
glioma9
head and neck tumor89
kidney tumor29
leukemia31
liver tumor41
lung tumor145
lymphoma27
non-neoplasia20
ovarian tumor65
pancreatic tumor28
prostate cancer9
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor88
Developmental Stage
TissuesTPM*
adult31
embryoid body28
blastocyst16
fetus19
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.3
adrenal gland14.9
appendix16.8
bone marrow72.3
colon8.8
duodenum11.5
esophagus12.4
gallbladder32.4
heart muscle2.9
kidney3.6
liver11
lung13.9
lymph node9.8
ovary3.8
pancreas5.5
placenta3.3
prostate11.7
salivary gland6.1
skin13.1
small intestine13.9
spleen8.8
stomach12.8
testis3.6
thyroid gland2.2
urinary bladder34.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*610562, gene) Zinc finger ccch domain-containing protein 12a; ZC3H12AOMIM


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