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> Protein (NX_Q5JST6)
Protein (NX_Q5JST6)
Gene SymbolEFHC2 to neXtProt (NX_Q5JST6)
DescriptionEF-hand domain-containing family member C2
LocationXp11.3 (44007128 ~ 44202918) to Ensembl
Sequene Features : Isoforms 2, Variants 83, PTMsto neXtProt Sequence Features
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .calcium ion binding .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 83 0
2014-09-19protein level
2 67 0
2014-05-27protein level
2 67 1
2014-02-25protein level
2 66 1
2013-12-09protein level
2 55 1
2013-11-01protein level
2 55 1
2013-09-12protein level
2 55 1
2013-08-17protein level
2 55 1
2013-07-15protein level
2 37 0
2013-06-11protein level
2 37 0
2013-02-12protein level
2 18 0
2012-12-20protein level
2 16 0
2012-10-30protein level
2 23 0
2012-10-07protein level
2 23 0
2012-08-24protein level
2 17 0
2012-07-28protein level
2 17 0
2012-06-08protein level
2 20 0
2012-05-07protein level
2 20 0
2012-04-10protein level
2 20 0
2012-01-13protein level
2 10 0
2011-12-20protein level
2 10 0
2011-11-11protein level
2 10 0
2011-08-23protein level
2 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
30 8 0 87340.7979
1 8 0 19029.4254
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2349927,EBI-711301 COPE  
  .membrane organization
.COPI coating of Golgi vesicle
.protein transport
  + 3 more...
.structural molecule activity .COPI vesicle coat
.Golgi apparatus
2 EBI-2349927,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.endoplasmic reticulum
3 EBI-2349927,EBI-741582 PLOD3  
  .basement membrane assembly
.lung morphogenesis
.epidermis morphogenesis
  + 9 more...
.procollagen galactosyltransferase activity
.procollagen glucosyltransferase activity
.L-ascorbic acid binding
  + 2 more...
.extracellular exosome
.rough endoplasmic reticulum membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
4 EBI-2349927,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.Golgi-associated vesicle
5 EBI-2349927,EBI-10192241 CLIC3  
  .chloride transmembrane transport
.signal transduction
.chloride transport
.chloride channel activity
.voltage-gated ion channel activity
.extracellular exosome
.chloride channel complex
6 EBI-2349927,EBI-750589 PBLD  
  .negative regulation of pathway-restricted SMAD protein phosphorylation
.negative regulation of SMAD protein import into nucleus
.negative regulation of epithelial cell proliferation
  + 5 more...
.isomerase activity .extracellular exosome
7 EBI-2349927,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
8 EBI-2349927,EBI-489887 EMD  
  .cellular response to growth factor stimulus
.regulation of canonical Wnt signaling pathway
.negative regulation of fibroblast proliferation
  + 8 more...
.beta-tubulin binding
.actin binding
.nuclear membrane
.integral component of membrane
  + 5 more...
9 EBI-2349927,EBI-10224192 RUNX1T1  
  .negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.generation of precursor metabolites and energy
.metal ion binding
.identical protein binding
.transcription corepressor activity
  + 2 more...
.nuclear matrix
10 EBI-2349927,EBI-602199 ARHGEF5  
  .positive regulation of podosome assembly
.regulation of GTPase activity
.intracellular signal transduction
  + 2 more...
.GTP binding
.Rho guanyl-nucleotide exchange factor activity
11 EBI-2349927,EBI-1383632 PTK6  
  .cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
  + 2 more...
12 EBI-2349927,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
13 EBI-2349927,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
14 EBI-2349927,EBI-752007 JAKMIP2  
  .N/A .N/A .Golgi apparatus
15 EBI-2349927,EBI-997311 EDC3  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.identical protein binding
.RNA binding
.cytoplasmic mRNA processing body
16 EBI-2349927,EBI-10185348 CCDC120  
  .N/A .N/A .N/A
17 EBI-2349927,EBI-3918381 TSSK3  
  .intracellular signal transduction
.cell differentiation
.regulation of signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
18 EBI-2349927,EBI-9675976 SNRNP25  
  .RNA splicing
.mRNA processing
.N/A .intercellular bridge
.U12-type spliceosomal complex
  + 2 more...
19 EBI-2349927,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
20 EBI-2349927,EBI-1175354 EGLN3  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of neuron apoptotic process
  + 7 more...
.peptidyl-proline 4-dioxygenase activity
.L-ascorbic acid binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
.iron ion binding
21 EBI-2349927,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
  + 3 more...
22 EBI-2349927,EBI-1053490 NCDN  
  .regulation of neuronal synaptic plasticity
.bone resorption
.neuron projection development
.N/A .neuronal cell body
23 EBI-2349927,EBI-10249760 NDOR1  
  .oxidation-reduction process
.small molecule metabolic process
.cellular response to menadione
  + 2 more...
.NADP binding
.flavin adenine dinucleotide binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
  + 4 more...
.perinuclear region of cytoplasm
.intermediate filament cytoskeleton
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
bone marrow20
connective tissue6
mammary gland6
pituitary gland60
Health State
breast (mammary gland) tumor10
germ cell tumor3
kidney tumor14
lung tumor19
soft tissue/muscle tissue tumor7
Developmental Stage
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
bone marrow1.3
cerebral cortex2.1
heart muscle3.8
salivary gland9.1
small intestine1.1
thyroid gland3.6
urinary bladder1.6
TumorNumber of patients and Staining levels
breast cancer
cervical cancer
colorectal cancer
endometrial cancer
head and neck cancer
liver cancer
lung cancer
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
No.Disease DescriptionRef.
1(*300817, gene) Ef-hand domain (c-terminal)-containing protein 2; EFHC2OMIM

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