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> Protein (NX_Q5S007)
Protein (NX_Q5S007)
Protein
Gene SymbolLRRK2 to neXtProt (NX_Q5S007)
DescriptionLeucine-rich repeat serine/threonine-protein kinase 2
Chromosome12
Location12q12 (40590546 ~ 40763087) to Ensembl
Sequene Features : Isoforms 1, Variants 514, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 514 1
2014-09-19protein level
1 415 1
2014-05-27protein level
1 413 1
2014-02-25protein level
1 414 1
2013-12-09protein level
1 326 1
2013-11-01protein level
1 307 1
2013-09-12protein level
1 307 1
2013-08-17protein level
1 307 1
2013-07-15protein level
1 213 1
2013-06-11protein level
1 213 1
2013-02-12protein level
1 119 0
2012-12-20protein level
1 117 0
2012-10-30protein level
1 135 0
2012-10-07protein level
1 135 0
2012-08-24protein level
1 127 0
2012-07-28protein level
1 127 0
2012-06-08protein level
1 134 0
2012-05-07protein level
1 90 0
2012-04-10protein level
1 90 0
2012-01-13protein level
1 108 0
2011-12-20protein level
1 108 0
2011-11-11protein level
1 108 0
2011-08-23protein level
1 108 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5S007-1
127 0 0 285918.1392
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-5323863,EBI-724571 DNM1L  
  .positive regulation of intrinsic apoptotic signaling pathway
.regulation of mitochondrion degradation
.regulation of peroxisome organization
  + 22 more...
.protein homodimerization activity
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.perinuclear region of cytoplasm
.protein complex
.intracellular membrane-bounded organelle
  + 11 more...
2 EBI-5323863,EBI-6504027 DVL1  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 28 more...
.identical protein binding
.protein kinase binding
.enzyme binding
.frizzled binding
.synapse
.neuronal cell body
.cytoplasmic vesicle
  + 8 more...
3 EBI-5323863,EBI-740850 DVL2  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 20 more...
.identical protein binding
.frizzled binding
.clathrin-coated endocytic vesicle
.apical part of cell
.cytoplasmic vesicle
  + 4 more...
4 EBI-5323863,EBI-492605 MAP2K7  
  .cellular response to sorbitol
.stress-activated MAPK cascade
.innate immune response
  + 22 more...
.protein phosphatase binding
.protein kinase binding
.enzyme binding
  + 6 more...
.cytosol
.cytoplasm
.nucleus
.intracellular
5 EBI-5323863,EBI-372165 RAB29  
  .positive regulation of intracellular protein transport
.retrograde transport, plasma membrane to Golgi
.Rab protein signal transduction
  + 5 more...
.GTP binding
.GTPase activity
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 5 more...
6 EBI-5323863,EBI-714707 GAK  
  .positive regulation of neural precursor cell proliferation
.clathrin-mediated endocytosis
.clathrin coat disassembly
  + 8 more...
.ATP binding
.protein serine/threonine kinase activity
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 2 more...
7 EBI-5323863,EBI-357515 SEC16A  
  .COPII vesicle coating
.substantia nigra development
.protein transport
.endoplasmic reticulum organization
.N/A .cytosol
.Golgi apparatus
.endoplasmic reticulum membrane
  + 2 more...
8 EBI-5323863,EBI-716346 PARK2  
  .negative regulation of reactive oxygen species metabolic process
.regulation of reactive oxygen species metabolic process
.negative regulation of spontaneous neurotransmitter secretion
  + 78 more...
.F-box domain binding
.ubiquitin-specific protease binding
.cullin family protein binding
  + 21 more...
.Parkin-FBXW7-Cul1 ubiquitin ligase complex
.Lewy body
.perinuclear region of cytoplasm
  + 9 more...
9 EBI-5323863,EBI-1054131 OPA1  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.cellular senescence
.negative regulation of release of cytochrome c from mitochondria
  + 10 more...
.GTP binding
.GTPase activity
.magnesium ion binding
.dendrite
.mitochondrial crista
.integral component of membrane
  + 7 more...
10 EBI-5323863,EBI-910915 LRP6  
  .negative regulation of planar cell polarity pathway involved in neural tube closure
.negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
.negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
  + 77 more...
.coreceptor activity involved in Wnt signaling pathway
.Wnt-activated receptor activity
.protein homodimerization activity
  + 8 more...
.synapse
.receptor complex
.neuronal cell body
  + 7 more...
11 EBI-5323863,EBI-3324756 MFN2  
  .mitochondrion localization
.negative regulation of smooth muscle cell proliferation
.camera-type eye morphogenesis
  + 10 more...
.ubiquitin protein ligase binding
.GTP binding
.GTPase activity
.intrinsic component of mitochondrial outer membrane
.integral component of membrane
.microtubule cytoskeleton
  + 3 more...
12 EBI-5323863,EBI-296723 SNAPIN  
  .positive regulation of late endosome to lysosome transport
.autophagic vacuole maturation
.terminal button organization
  + 14 more...
.SNARE binding .perinuclear region of cytoplasm
.synapse
.BLOC-1 complex
  + 9 more...
13 EBI-5323863,EBI-355275 BAG2  
  .regulation of cellular response to heat
.cellular response to heat
.protein metabolic process
.protein folding
.identical protein binding .cytosol
14 EBI-5323863,EBI-747185 BAG3  
  .regulation of cellular response to heat
.extrinsic apoptotic signaling pathway in absence of ligand
.cellular response to mechanical stimulus
  + 8 more...
.N/A .neuron projection
.Z disc
.plasma membrane
  + 2 more...
15 EBI-5323863,EBI-355007 TUBB4A  
  .protein polymerization
.'de novo' posttranslational protein folding
.cellular protein metabolic process
  + 5 more...
.GTP binding
.structural constituent of cytoskeleton
.GTPase activity
.extracellular exosome
.myelin sheath
.neuronal cell body
  + 5 more...
16 EBI-5323863,EBI-712619 CHGB  
  .N/A .hormone activity .secretory granule
.extracellular region
17 EBI-5323863,EBI-355133 SLC25A5  
  .negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
.regulation of insulin secretion
.small molecule metabolic process
  + 6 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.adenine transmembrane transporter activity
.MMXD complex
.extracellular exosome
.mitochondrial nucleoid
  + 5 more...
18 EBI-5323863,EBI-358748 LDHB  
  .small molecule metabolic process
.cellular metabolic process
.NAD metabolic process
  + 3 more...
.NAD binding
.L-lactate dehydrogenase activity
.extracellular exosome
.membrane raft
.membrane
  + 3 more...
19 EBI-5323863,EBI-350864 TUBB  
  .cell division
.protein polymerization
.spindle assembly
  + 8 more...
.MHC class I protein binding
.ubiquitin protein ligase binding
.GTP binding
  + 3 more...
.extracellular exosome
.cell body
.cytoplasmic ribonucleoprotein granule
  + 5 more...
20 EBI-5323863,EBI-4370304 BCL2  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
21 EBI-5323863,EBI-7796412 MAPT  
  .regulation of microtubule-based movement
.generation of neurons
.axon extension
  + 13 more...
.lipoprotein particle binding
.apolipoprotein binding
.enzyme binding
  + 3 more...
.tubulin complex
.cytoplasmic ribonucleoprotein granule
.nuclear periphery
  + 7 more...
22 EBI-5323863,EBI-351896 HSPA8  
  .negative regulation of fibril organization
.regulation of cellular response to heat
.clathrin coat disassembly
  + 18 more...
.C3HC4-type RING finger domain binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.blood microparticle
.extracellular exosome
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
  + 13 more...
23 EBI-5323863,EBI-359074 SLC25A4  
  .negative regulation of necroptotic process
.regulation of insulin secretion
.small molecule metabolic process
  + 7 more...
.adenine transmembrane transporter activity .integral component of plasma membrane
.mitochondrial inner membrane
.mitochondrion
.nucleus
24 EBI-5323863,EBI-356254 SLC25A6  
  .regulation of insulin secretion
.active induction of host immune response by virus
.small molecule metabolic process
  + 9 more...
.ATP:ADP antiporter activity .integral component of membrane
.mitochondrial inner membrane presequence translocase complex
.mitochondrial inner membrane
  + 2 more...
25 EBI-5323863,EBI-443446 RPS2  
  .positive regulation of transferase activity
.cellular protein metabolic process
.viral transcription
  + 9 more...
.poly(A) RNA binding
.enzyme binding
.fibroblast growth factor binding
  + 2 more...
.extracellular exosome
.cytosolic small ribosomal subunit
.membrane
  + 5 more...
26 EBI-5323863,EBI-476586 PRKACA  
  .regulation of tight junction assembly
.negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.cell communication by electrical coupling involved in cardiac conduction
  + 47 more...
.protein kinase A regulatory subunit binding
.ubiquitin protein ligase binding
.protein kinase binding
  + 3 more...
.ciliary base
.sperm midpiece
.extracellular exosome
  + 11 more...
27 EBI-5323863,EBI-351193 RPS3  
  .positive regulation of apoptotic signaling pathway
.positive regulation of DNA N-glycosylase activity
.cell division
  + 20 more...
.iron-sulfur cluster binding
.NF-kappaB binding
.protein kinase A binding
  + 8 more...
.extracellular exosome
.ruffle membrane
.ribonucleoprotein complex
  + 9 more...
28 EBI-5323863,EBI-528768 MSN  
  .regulation of lymphocyte migration
.establishment of endothelial barrier
.leukocyte migration
  + 4 more...
.cell adhesion molecule binding
.protein kinase binding
.structural constituent of cytoskeleton
  + 2 more...
.blood microparticle
.cell periphery
.extracellular exosome
  + 15 more...
29 EBI-5323863,EBI-356849 RPL13  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic ribosome
.cytosolic large ribosomal subunit
.membrane
  + 4 more...
30 EBI-5323863,EBI-359854 YWHAQ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 8 more...
.protein N-terminus binding .extracellular exosome
.protein complex
.cytoplasmic vesicle membrane
  + 4 more...
31 EBI-5323863,EBI-748336 PRDX3  
  .regulation of mitochondrial membrane potential
.positive regulation of NF-kappaB transcription factor activity
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
  + 14 more...
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.protein kinase binding
.kinase binding
  + 3 more...
.extracellular exosome
.cytosol
.early endosome
  + 3 more...
32 EBI-5323863,EBI-719602 ECHS1  
  .small molecule metabolic process
.cellular lipid metabolic process
.fatty acid beta-oxidation
.enoyl-CoA hydratase activity .extracellular exosome
.mitochondrial matrix
.mitochondrion
33 EBI-5323863,EBI-296087 AKT1  
  .negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
.response to insulin-like growth factor stimulus
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 108 more...
.14-3-3 protein binding
.phosphatidylinositol-3,4-bisphosphate binding
.identical protein binding
  + 8 more...
.ciliary basal body
.microtubule cytoskeleton
.cell-cell junction
  + 7 more...
34 EBI-5323863,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
35 EBI-5323863,EBI-985879 SNCA  
  .regulation of reactive oxygen species biosynthetic process
.regulation of synaptic vesicle recycling
.positive regulation of hydrogen peroxide catabolic process
  + 63 more...
.phosphoprotein binding
.tau protein binding
.dynein binding
  + 14 more...
.perinuclear region of cytoplasm
.fibril
.terminal bouton
  + 21 more...
36 EBI-5323863,EBI-712388 RGS2  
  .regulation of adrenergic receptor signaling pathway
.positive regulation of cardiac muscle contraction
.relaxation of vascular smooth muscle
  + 13 more...
.calmodulin binding
.GTPase activator activity
.neuron projection
.cytoplasmic side of plasma membrane
.plasma membrane
  + 5 more...
37 EBI-5323863,EBI-356336 RPS27  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 11 more...
.poly(A) RNA binding
.zinc ion binding
.structural constituent of ribosome
.DNA binding
.cytosolic small ribosomal subunit
.ribosome
.cytosol
.nucleus
38 EBI-5323863,EBI-751664 MATK  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 8 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytosol
39 EBI-5323863,EBI-602462 MAP2K3  
  .cardiac muscle contraction
.stress-activated MAPK cascade
.positive regulation of transcription, DNA-templated
  + 21 more...
.protein kinase binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.membrane
.cytosol
.cytoplasm
.nucleoplasm
40 EBI-5323863,EBI-9517186 MAP1B  
  .establishment of monopolar cell polarity
.axon extension
.mitochondrion transport along microtubule
  + 5 more...
.structural molecule activity .dendritic spine
.cell junction
.postsynaptic density
  + 5 more...
41 EBI-5323863,EBI-10106282 CSNK1A1  
  .positive regulation of canonical Wnt signaling pathway
.cell division
.peptidyl-serine phosphorylation
  + 7 more...
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.primary cilium
.nuclear speck
.membrane
  + 4 more...
42 EBI-5323863,EBI-373586 GSK3B  
  .positive regulation of stem cell differentiation
.negative regulation of glycogen (starch) synthase activity
.negative regulation of type B pancreatic cell development
  + 61 more...
.NF-kappaB binding
.tau-protein kinase activity
.protein kinase A catalytic subunit binding
  + 8 more...
.perinuclear region of cytoplasm
.membrane raft
.dendritic shaft
  + 11 more...
43 EBI-5323863,EBI-356746 RPL14  
  .cellular protein metabolic process
.ribosomal large subunit biogenesis
.viral transcription
  + 10 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 2 more...
44 EBI-5323863,EBI-448135 MAP2K6  
  .cellular response to sorbitol
.nucleotide-binding oligomerization domain containing signaling pathway
.cardiac muscle contraction
  + 33 more...
.protein kinase binding
.ATP binding
.protein tyrosine kinase activity
  + 2 more...
.cytoskeleton
.cytosol
.cytoplasm
.nucleoplasm
45 EBI-5323863,EBI-358616 DAPK1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.extrinsic apoptotic signaling pathway in absence of ligand
  + 13 more...
.identical protein binding
.syntaxin-1 binding
.GTP binding
  + 5 more...
.actin cytoskeleton
.plasma membrane
.cytoplasm
46 EBI-5323863,EBI-353105 RPS20  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 9 more...
.poly(A) RNA binding
.structural constituent of ribosome
.extracellular exosome
.cytosolic small ribosomal subunit
.membrane
  + 2 more...
47 EBI-5323863,EBI-81752 CDC42  
  .positive regulation of substrate adhesion-dependent cell spreading
.positive regulation of intracellular protein transport
.epithelial cell-cell adhesion
  + 61 more...
.identical protein binding
.apolipoprotein A-I receptor binding
.thioesterase binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.spindle midzone
  + 17 more...
48 EBI-5323863,EBI-399401 RAB5B  
  .plasma membrane to endosome transport
.Rab protein signal transduction
.regulation of endocytosis
  + 4 more...
.GTP-dependent protein binding
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.melanosome
.early endosome membrane
  + 6 more...
49 EBI-5323863,EBI-359832 YWHAG  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.negative regulation of protein serine/threonine kinase activity
  + 14 more...
.poly(A) RNA binding
.protein kinase C inhibitor activity
.insulin-like growth factor receptor binding
.protein kinase C binding
.extracellular exosome
.cytoplasmic vesicle membrane
.membrane
  + 2 more...
50 EBI-5323863,EBI-357253 PPP1CA  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.cell division
.branching morphogenesis of an epithelial tube
  + 15 more...
.metal ion binding
.ribonucleoprotein complex binding
.phosphatase activity
.protein serine/threonine phosphatase activity
.PTW/PP1 phosphatase complex
.MLL5-L complex
.extracellular exosome
  + 10 more...
51 EBI-5323863,EBI-352480 RPS16  
  .cellular protein metabolic process
.ribosomal small subunit biogenesis
.viral transcription
  + 10 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.extracellular exosome
.cytosolic small ribosomal subunit
.membrane
  + 3 more...
52 EBI-5323863,EBI-356498 YWHAE  
  .negative regulation of peptidyl-serine dephosphorylation
.regulation of potassium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
  + 27 more...
.phosphoprotein binding
.phosphoserine binding
.protein heterodimerization activity
  + 7 more...
.extracellular exosome
.melanosome
.cytoplasmic vesicle membrane
  + 6 more...
53 EBI-5323863,EBI-353072 RPS23  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.structural constituent of ribosome
.cytosolic small ribosomal subunit
.membrane
.ribosome
  + 3 more...
54 EBI-5323863,EBI-1047710 RPS11  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.rRNA binding
.structural constituent of ribosome
.extracellular exosome
.cytosolic small ribosomal subunit
.membrane
  + 5 more...
55 EBI-5323863,EBI-353254 RPL23A  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 9 more...
.poly(A) RNA binding
.rRNA binding
.structural constituent of ribosome
.nucleotide binding
.extracellular exosome
.cytosolic large ribosomal subunit
.cytosol
  + 3 more...
56 EBI-5323863,EBI-372635 RPS15  
  .cellular protein metabolic process
.ribosomal small subunit biogenesis
.viral transcription
  + 13 more...
.poly(A) RNA binding
.structural constituent of ribosome
.DNA binding
.cytosolic small ribosomal subunit
.membrane
.focal adhesion
  + 4 more...
57 EBI-5323863,EBI-356860 RPL10A  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 9 more...
.poly(A) RNA binding
.structural constituent of ribosome
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 6 more...
58 EBI-5323863,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
59 EBI-5323863,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
60 EBI-5323863,EBI-306940 YWHAH  
  .regulation of sodium ion transmembrane transporter activity
.positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
  + 16 more...
.protein heterodimerization activity
.ion channel binding
.glucocorticoid receptor binding
  + 4 more...
.extracellular exosome
.cytoplasmic vesicle membrane
.intercalated disc
  + 3 more...
61 EBI-5323863,EBI-713135 DNM1  
  .clathrin-mediated endocytosis
.ephrin receptor signaling pathway
.receptor internalization
  + 4 more...
.poly(A) RNA binding
.identical protein binding
.protein kinase binding
  + 2 more...
.extracellular exosome
.membrane coat
.plasma membrane
.microtubule
62 EBI-5323863,EBI-494804 FADD  
  .positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 49 more...
.identical protein binding
.death effector domain binding
.tumor necrosis factor receptor superfamily binding
  + 2 more...
.ripoptosome
.membrane raft
.cell body
  + 4 more...
63 EBI-5323863,EBI-716258 NFATC2  
  .B cell receptor signaling pathway
.positive regulation of transcription, DNA-templated
.innate immune response
  + 8 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.nuclear transcription factor complex
.ribonucleoprotein complex
.actin cytoskeleton
  + 5 more...
64 EBI-5323863,EBI-9837586 RAB32  
  .melanosome assembly
.phagosome maturation
.endosome to melanosome transport
  + 4 more...
.BLOC-2 complex binding
.AP-3 adaptor complex binding
.AP-1 adaptor complex binding
  + 3 more...
.phagocytic vesicle
.melanosome
.phagocytic vesicle membrane
  + 4 more...
65 EBI-5323863,EBI-717515 ARHGEF7  
  .positive regulation of lamellipodium morphogenesis
.positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
  + 14 more...
.protein kinase binding
.Rho guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.protein complex
.neuronal cell body
.neuron projection
  + 5 more...
66 EBI-5323863,EBI-295634 CDC37  
  .regulation of type I interferon-mediated signaling pathway
.regulation of interferon-gamma-mediated signaling pathway
.protein stabilization
  + 3 more...
.chaperone binding
.unfolded protein binding
.heat shock protein binding
.kinase binding
.extracellular exosome
.protein complex
.ruffle membrane
  + 2 more...
67 EBI-5323863,EBI-1050422 LRRK1  
  .positive regulation of intracellular signal transduction
.negative regulation of peptidyl-tyrosine phosphorylation
.positive regulation of peptidyl-tyrosine phosphorylation
  + 3 more...
.metal ion binding
.identical protein binding
.GTP binding
  + 2 more...
.mitochondrion
.cytoplasm
68 EBI-5323863,EBI-6288865 ARFGAP1  
  .membrane organization
.COPI coating of Golgi vesicle
.cellular protein metabolic process
  + 5 more...
.zinc ion binding
.GTPase activator activity
.synapse
.Golgi-associated vesicle membrane
.cytosol
69 EBI-5323863,EBI-295695 NUP133  
  .regulation of cellular response to heat
.transmembrane transport
.paraxial mesoderm development
  + 20 more...
.nucleocytoplasmic transporter activity .nuclear membrane
.nuclear pore outer ring
.membrane
  + 4 more...
70 EBI-5323863,EBI-739789 DVL3  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 12 more...
.protein heterodimerization activity
.beta-catenin binding
.frizzled binding
  + 2 more...
.cytosol
71 EBI-5323863,EBI-373615 NEK1  
  .cell division
.cilium assembly
.response to ionizing radiation
  + 5 more...
.metal ion binding
.kinase activity
.ATP binding
  + 4 more...
.centrosome
.cytoplasm
.nucleus
.pericentriolar material
72 EBI-5323863,EBI-77938 SH3GL2  
  .membrane organization
.synaptic vesicle endocytosis
.neurotrophin TRK receptor signaling pathway
  + 8 more...
.identical protein binding
.lipid binding
.extracellular exosome
.clathrin-coated endocytic vesicle membrane
.plasma membrane
  + 2 more...
73 EBI-5323863,EBI-1053685 PAK6  
  .regulation of MAPK cascade
.regulation of apoptotic process
.activation of protein kinase activity
  + 8 more...
.Rac GTPase binding
.ATP binding
.protein serine/threonine kinase activity
.cytoplasm
.nucleus
74 EBI-5323863,EBI-528269 AGO2  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.mRNA cleavage involved in gene silencing by siRNA
.RNA phosphodiester bond hydrolysis, endonucleolytic
  + 25 more...
.endoribonuclease activity, cleaving miRNA-paired mRNA
.pre-miRNA binding
.endoribonuclease activity, cleaving siRNA-paired mRNA
  + 12 more...
.RISC-loading complex
.micro-ribonucleoprotein complex
.ribonucleoprotein complex
  + 9 more...
75 EBI-5323863,EBI-356517 BAG5  
  .negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.regulation of cellular response to heat
.regulation of inclusion body assembly
  + 7 more...
.chaperone binding
.ubiquitin protein ligase binding
.protein kinase binding
.perinuclear region of cytoplasm
.inclusion body
.membrane
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood24
bone27
bone marrow82
brain10
connective tissue13
embryonic tissue4
eye4
intestine4
kidney52
liver4
lung17
lymph node89
mammary gland6
mouth15
nerve64
pharynx24
prostate5
skin4
testis2
thymus25
thyroid193
trachea38
Health State
TissuesTPM*
normal12
breast (mammary gland) tumor10
chondrosarcoma36
germ cell tumor3
head and neck tumor74
leukemia42
lung tumor9
non-neoplasia10
skin tumor7
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult15
fetus8
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue5.4
adrenal gland4.4
appendix14
bone marrow8.3
cerebral cortex4.8
colon2.7
duodenum1.3
esophagus9.5
gallbladder9.3
heart muscle2.9
kidney12.3
liver4.7
lung53.4
lymph node8.9
ovary8.7
pancreas2.7
placenta1.8
prostate3.4
salivary gland3
skin2
small intestine2.3
spleen11.7
stomach1.9
testis1.6
thyroid gland2.9
urinary bladder6.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#168600, phenotype) Parkinson disease, late-onset; PDOMIM
2(#607060, phenotype) Parkinson disease 8, autosomal dominant; PARK8OMIM
3(*609007, gene) Leucine-rich repeat kinase 2; LRRK2OMIM


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