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> Protein (NX_Q5ST30)
Protein (NX_Q5ST30)
Protein
Gene SymbolVARS2 to neXtProt (NX_Q5ST30)
DescriptionValine--tRNA ligase, mitochondrial
Chromosome6
Location6p21.33 (30876019 ~ 30894236) to Ensembl
Sequene Features : Isoforms 4, Variants 104, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.gene expression
.valyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.valine-tRNA ligase activity
.aminoacyl-tRNA editing activity
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 104 4
2014-09-19protein level
4 69 4
2014-05-27protein level
4 68 5
2014-02-25protein level
4 37 5
2013-12-09protein level
4 27 5
2013-11-01protein level
4 27 3
2013-09-12protein level
4 27 3
2013-08-17protein level
4 27 3
2013-07-15protein level
4 27 1
2013-06-11protein level
4 27 1
2013-02-12protein level
2 27 2
2012-12-20protein level
2 27 2
2012-10-30protein level
2 27 2
2012-10-07protein level
2 27 1
2012-08-24protein level
2 27 1
2012-07-28protein level
2 27 1
2012-06-08protein level
2 28 1
2012-05-07protein level
2 28 1
2012-04-10protein level
2 29 1
2012-01-13protein level
2 19 1
2011-12-20protein level
2 19 1
2011-11-11protein level
2 19 1
2011-08-23protein level
2 12 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5ST30-1
1 45 0 118414.438
NX_Q5ST30-2
4 17 0 55042.4433
NX_Q5ST30-3
1 38 0 102350.1208
NX_Q5ST30-4
1 45 0 121465.9827
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10244997,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-10244997,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
3 EBI-10244969,EBI-944295 MAL2  
  .N/A .N/A .extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 3 more...
4 EBI-10244969,EBI-2548702 CMTM5  
  .negative regulation of myoblast differentiation
.chemotaxis
.N/A .integral component of membrane
.extracellular space
5 EBI-10244997,EBI-743598 ABI2  
  .positive regulation of Arp2/3 complex-mediated actin nucleation
.peptidyl-tyrosine phosphorylation
.Rac protein signal transduction
  + 5 more...
.proline-rich region binding
.protein complex binding
.ubiquitin protein ligase binding
  + 4 more...
.SCAR complex
.filopodium
.lamellipodium
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood40
brain80
cervix20
connective tissue26
embryonic tissue37
eye43
intestine12
kidney33
larynx42
liver48
lung32
lymph925
lymph node11
mammary gland26
mouth15
muscle18
ovary68
pancreas28
placenta7
prostate26
skin52
spleen56
stomach41
testis64
thymus62
thyroid21
tonsil58
trachea135
uterus34
vascular38
Health State
TissuesTPM*
normal42
breast (mammary gland) tumor21
chondrosarcoma48
gastrointestinal tumor42
germ cell tumor15
glioma65
head and neck tumor14
kidney tumor29
leukemia42
liver tumor52
lung tumor29
lymphoma567
non-neoplasia10
ovarian tumor91
pancreatic tumor57
primitive neuroectodermal tumor of the CNS15
prostate cancer19
retinoblastoma107
skin tumor63
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult22
blastocyst113
neonate32
fetus52
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.7
adrenal gland9
appendix12
bone marrow7.3
cerebral cortex19.3
colon9.2
duodenum11.5
esophagus12.7
gallbladder10.5
heart muscle8.4
kidney12.9
liver9.5
lung10.9
lymph node13.3
ovary15.6
pancreas7.3
placenta7.9
prostate9.2
salivary gland9.4
skin10.5
small intestine13.8
spleen15.5
stomach11.5
testis12.7
thyroid gland13.1
urinary bladder9.4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*612802, gene) Valyl-trna synthetase 2; VARS2OMIM


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