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> Protein (NX_Q5T0T0)
Protein (NX_Q5T0T0)
Protein
Gene SymbolMARCH8 to neXtProt (NX_Q5T0T0)
DescriptionE3 ubiquitin-protein ligase MARCH8
Chromosome10
Location10q11.21 (45950035 ~ 46090354) to Ensembl
Sequene Features : Isoforms 2, Variants 43, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of MHC class II biosynthetic process
.antigen processing and presentation of peptide antigen via MHC class II
.protein polyubiquitination
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.early endosome membrane
.cytoplasmic vesicle membrane
.integral component of membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 43 0
2014-09-19protein level
2 36 0
2014-05-27protein level
1 25 0
2014-02-25protein level
1 25 0
2013-12-09protein level
1 21 0
2013-11-01protein level
1 21 0
2013-09-12protein level
1 21 0
2013-08-17protein level
1 21 0
2013-07-15protein level
1 18 0
2013-06-11protein level
1 18 0
2013-02-12protein level
1 8 0
2012-12-20protein level
1 8 0
2012-10-30protein level
1 8 0
2012-10-07protein level
1 8 0
2012-08-24protein level
1 5 0
2012-07-28protein level
1 5 0
2012-06-08protein level
1 5 0
2012-05-07protein level
1 5 0
2012-04-10protein level
1 5 0
2012-01-13protein level
1 5 0
2011-12-20protein level
1 5 0
2011-11-11protein level
1 5 0
2011-08-23protein level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5T0T0-1
1 12 0 32943.1691
NX_Q5T0T0-2
17 12 0 63277.9921
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
ascites25
blood49
bone55
bone marrow184
brain27
cervix41
connective tissue13
embryonic tissue9
esophagus49
eye81
heart11
intestine25
kidney23
larynx42
liver29
lung11
lymph45
lymph node167
mammary gland6
mouth30
muscle28
ovary59
pancreas70
parathyroid97
pharynx24
pituitary gland60
placenta21
prostate5
skin14
stomach83
testis128
thymus25
tonsil58
uterus51
vascular19
Health State
TissuesTPM*
normal45
cervical tumor57
chondrosarcoma60
colorectal tumor17
esophageal tumor57
gastrointestinal tumor8
germ cell tumor11
glioma46
head and neck tumor22
leukemia190
liver tumor31
lymphoma41
non-neoplasia41
ovarian tumor65
pancreatic tumor66
retinoblastoma43
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult39
embryoid body28
fetus59
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue13.3
adrenal gland20.8
appendix15.3
bone marrow31.2
cerebral cortex13.8
colon20.9
duodenum13.6
esophagus15.7
gallbladder20.8
heart muscle22
kidney16.7
liver9.2
lung17.2
lymph node21.1
ovary25.5
pancreas15.1
placenta11.5
prostate12.5
salivary gland12.9
skin11.2
small intestine22.3
spleen19.9
stomach14.3
testis60.2
thyroid gland23.5
urinary bladder25
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastMedium
bronchusHigh
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleLow
hippocampusLow
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeLow
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasLow
parathyroid glandMedium
placentaMedium
prostateLow
rectumHigh
salivary glandMedium
seminal vesicleLow
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineHigh
soft tissue 1Medium
soft tissue 2Low
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*613335, gene) Membrane-associated ring-ch finger protein 8; MARCH8OMIM


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