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> Protein (NX_Q5T700)
Protein (NX_Q5T700)
Protein
Gene SymbolLDLRAD1 to neXtProt (NX_Q5T700)
DescriptionLow-density lipoprotein receptor class A domain-containing protein 1
Chromosome1
Location1p32.3 (54474412 ~ 54483856) to Ensembl
Sequene Features : Isoforms 4, Variants 37, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.N/A .N/A .integral component of membrane
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
4 37 6
2014-09-19transcript level
4 31 6
2014-05-27transcript level
4 30 6
2014-02-25transcript level
3 30 6
2013-12-09transcript level
3 23 6
2013-11-01transcript level
3 21 6
2013-09-12transcript level
3 21 6
2013-08-17transcript level
3 21 6
2013-07-15transcript level
3 17 6
2013-06-11transcript level
3 17 6
2013-02-12transcript level
3 14 15
2012-12-20transcript level
3 14 15
2012-10-30transcript level
3 15 15
2012-10-07transcript level
3 15 6
2012-08-24transcript level
3 9 6
2012-07-28transcript level
3 8 6
2012-06-08transcript level
3 8 6
2012-05-07transcript level
3 8 6
2012-04-10transcript level
3 8 6
2012-01-13transcript level
3 3 6
2011-12-20transcript level
3 3 6
2011-11-11transcript level
3 3 6
2011-08-23transcript level
3 3 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5T700-1
2 7 0 21818.864
NX_Q5T700-2
2 6 0 18153.9497
NX_Q5T700-3
1 3 0 12712.4357
NX_Q5T700-4
1 7 0 17661.605
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10173166,EBI-10173151 TMEM218  
  .N/A .N/A .integral component of membrane
2 EBI-10173166,EBI-849893 BNIP3L  
  .mitochondrial outer membrane permeabilization
.defense response to virus
.negative regulation of apoptotic process
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.lamin binding
.intrinsic component of membrane
.integral component of membrane
.endoplasmic reticulum
  + 3 more...
3 EBI-10173166,EBI-3932027 MAL  
  .positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
.transmembrane transport
.apical protein localization
  + 5 more...
.structural constituent of myelin sheath
.peptidase activator activity involved in apoptotic process
.channel activity
.lipid binding
.membrane raft
.extrinsic component of membrane
.apical plasma membrane
  + 3 more...
4 EBI-10173166,EBI-745376 SLC1A1  
  .cysteine transmembrane transport
.L-glutamate transmembrane transport
.D-aspartate import
  + 8 more...
.cysteine transmembrane transporter activity
.sodium:dicarboxylate symporter activity
.glutamate binding
  + 2 more...
.extracellular exosome
.apical plasma membrane
.membrane
  + 2 more...
5 EBI-10173166,EBI-3906138 PTTG1IP  
  .multicellular organismal development
.protein import into nucleus
.receptor activity .extracellular exosome
.integral component of membrane
.membrane
  + 2 more...
6 EBI-10173166,EBI-749464 BNIP3  
  .intrinsic apoptotic signaling pathway in response to hypoxia
.toxin transport
.mitochondrial outer membrane permeabilization
  + 28 more...
.GTPase binding
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.mitochondrial membrane
.integral component of mitochondrial outer membrane
.dendrite
  + 7 more...
7 EBI-10173166,EBI-750078 MALL  
  .cholesterol homeostasis .N/A .membrane raft
.clathrin-coated vesicle
.cytoplasmic membrane-bounded vesicle
  + 3 more...
8 EBI-10173166,EBI-2865663 LAPTM5  
  .transport .N/A .integral component of plasma membrane
.lysosomal membrane
.lysosome
9 EBI-10173166,EBI-2804156 OLFM4  
  .positive regulation of substrate adhesion-dependent cell spreading
.protein homooligomerization
.negative regulation of immune response
  + 2 more...
.cadherin binding
.protein homodimerization activity
.catalytic activity
.extracellular exosome
.perinuclear region of cytoplasm
.specific granule
  + 3 more...
10 EBI-10173166,EBI-10278423 TMEM190  
  .hematopoietic progenitor cell differentiation .N/A .integral component of membrane
.nucleus
.inner acrosomal membrane
11 EBI-10173166,EBI-6166686 GIMAP5  
  .negative regulation of lipid catabolic process
.negative regulation of T cell activation
.regulation of mitochondrial membrane permeability
  + 14 more...
.GTP binding .integral component of membrane
.lysosome
.mitochondrial outer membrane
12 EBI-10173166,EBI-10290200 GPR128  
  .G-protein coupled receptor signaling pathway .G-protein coupled receptor activity .integral component of membrane
.plasma membrane
13 EBI-10173166,EBI-348587 TMEM147  
  .protein destabilization .N/A .integral component of membrane
.endoplasmic reticulum membrane
14 EBI-10173166,EBI-10317612 MARCH2  
  .protein ubiquitination
.endocytosis
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasmic vesicle
.integral component of membrane
.endosome membrane
  + 3 more...
15 EBI-10173166,EBI-723716 VTI1B  
  .regulation of protein localization to plasma membrane
.membrane fusion
.vesicle fusion with Golgi apparatus
  + 8 more...
.chloride channel inhibitor activity
.SNAP receptor activity
.SNARE binding
.recycling endosome
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
heart11
lung29
pharynx24
Health State
TissuesTPM*
normal3
lung tumor9
Developmental Stage
TissuesTPM*
adult2
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1.1
gallbladder1.2
lung8.1
prostate1.1
stomach1.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bronchusMedium
cervix, uterineMedium
colonLow
duodenumLow
endometrium 1Low
endometrium 2Low
fallopian tubeMedium
gallbladderMedium
lateral ventricleLow
nasopharynxLow
pancreasLow
placentaLow
prostateMedium
rectumMedium
small intestineLow
thyroid glandMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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