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> Protein (NX_Q5T7P3)
Protein (NX_Q5T7P3)
Protein
Gene SymbolLCE1B to neXtProt (NX_Q5T7P3)
DescriptionLate cornified envelope protein 1B
Chromosome1
Location1q21.3 (152784447 ~ 152785585) to Ensembl
Sequene Features : Isoforms 1, Variants 48, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.keratinization .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
1 48 0
2014-09-19transcript level
1 35 0
2014-05-27transcript level
1 35 0
2014-02-25transcript level
1 33 0
2013-12-09transcript level
1 28 0
2013-11-01transcript level
1 26 0
2013-09-12transcript level
1 26 0
2013-08-17transcript level
1 26 0
2013-07-15transcript level
1 19 0
2013-06-11transcript level
1 19 0
2013-02-12transcript level
1 8 0
2012-12-20transcript level
1 8 0
2012-10-30transcript level
1 7 0
2012-10-07transcript level
1 7 0
2012-08-24transcript level
1 5 0
2012-07-28transcript level
1 5 0
2012-06-08transcript level
1 6 0
2012-05-07transcript level
1 4 0
2012-04-10transcript level
1 4 0
2012-01-13transcript level
1 5 0
2011-12-20transcript level
1 5 0
2011-11-11transcript level
1 5 0
2011-08-23transcript level
1 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5T7P3-1
0 0 3 11617.6656
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10245913,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
2 EBI-10245913,EBI-3866665 SPRY1  
  .negative regulation of ERK1 and ERK2 cascade
.bud elongation involved in lung branching
.negative regulation of neurotrophin TRK receptor signaling pathway
  + 10 more...
.N/A .plasma membrane
.cytosol
3 EBI-10245913,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
4 EBI-10245913,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
5 EBI-10245913,EBI-740446 OTX1  
  .diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
6 EBI-10245913,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
7 EBI-10245913,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
8 EBI-10245913,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
9 EBI-10245913,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
10 EBI-10245913,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
11 EBI-10245913,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
12 EBI-10245913,EBI-724373 BEND5  
  .N/A .N/A .Golgi apparatus
13 EBI-10245913,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
14 EBI-10245913,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
15 EBI-10245913,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
16 EBI-10245913,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
17 EBI-10245913,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
18 EBI-10245913,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
19 EBI-10245913,EBI-751260 KRTAP3-2  
  .N/A .structural molecule activity .keratin filament
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
skin23
Health State
TissuesTPM*
normal1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
skin102.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*612604, gene) Late cornified envelope protein 1b; LCE1BOMIM


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