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> Protein (NX_Q5T7P8)
Protein (NX_Q5T7P8)
Protein
Gene SymbolSYT6 to neXtProt (NX_Q5T7P8)
DescriptionSynaptotagmin-6
Chromosome1
Location1p13.2 (114631913 ~ 114696541) to Ensembl
Sequene Features : Isoforms 2, Variants 83, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.acrosomal vesicle exocytosis
.calcium ion-dependent exocytosis of neurotransmitter
.regulation of calcium ion-dependent exocytosis
  + 2 more...
.protein homodimerization activity
.clathrin binding
.syntaxin binding
.calcium ion binding
.perinuclear endoplasmic reticulum
.synaptic vesicle membrane
.cell junction
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 83 1
2014-09-19protein level
2 64 1
2014-05-27protein level
2 64 1
2014-02-25protein level
2 63 1
2013-12-09protein level
2 44 1
2013-11-01protein level
2 42 1
2013-09-12protein level
2 42 1
2013-08-17protein level
2 42 1
2013-07-15protein level
2 33 1
2013-06-11protein level
2 33 1
2013-02-12protein level
2 18 2
2012-12-20protein level
2 18 2
2012-10-30protein level
2 26 2
2012-10-07protein level
2 26 1
2012-08-24protein level
2 17 1
2012-07-28protein level
2 17 1
2012-06-08protein level
2 17 1
2012-05-07protein level
2 17 1
2012-04-10protein level
2 17 1
2012-01-13protein level
2 2 1
2011-12-20protein level
2 2 1
2011-11-11protein level
2 2 1
2011-08-23protein level
2 2 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5T7P8-1
5 19 0 57288.2272
NX_Q5T7P8-2
0 19 0 48411.6252
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10246152,EBI-740718 ZBTB43  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
2 EBI-10246152,EBI-740459 FXR2  
  .negative regulation of translation
.positive regulation of defense response to virus by host
.poly(A) RNA binding
.identical protein binding
.mRNA binding
.RNA binding
.extracellular exosome
.cytosolic large ribosomal subunit
.membrane
  + 3 more...
3 EBI-10246152,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
4 EBI-10246152,EBI-742790 TRIM32  
  .positive regulation of cell motility
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of viral release from host cell
  + 21 more...
.ubiquitin protein ligase activity
.protein self-association
.ubiquitin binding
  + 8 more...
.striated muscle myosin thick filament
.cytosol
.cytoplasm
.nucleus
5 EBI-10246152,EBI-357849 TNIP1  
  .modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade
.negative regulation of ERK1 and ERK2 cascade
.positive regulation of inflammatory response
  + 9 more...
.mitogen-activated protein kinase binding .cytoplasm
.nucleus
.intracellular
6 EBI-10246152,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
7 EBI-10246152,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
8 EBI-10246152,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
9 EBI-10246152,EBI-739789 DVL3  
  .positive regulation of canonical Wnt signaling pathway
.planar cell polarity pathway involved in neural tube closure
.cochlea morphogenesis
  + 12 more...
.protein heterodimerization activity
.beta-catenin binding
.frizzled binding
  + 2 more...
.cytosol
10 EBI-10246152,EBI-742740 ZBTB8A  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
11 EBI-10246152,EBI-744794 TSGA10  
  .cell projection assembly
.spermatogenesis
.N/A .neuron projection
.nuclear membrane
.motile cilium
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain2
embryonic tissue4
kidney4
lung2
pancreas23
prostate5
testis2
Health State
TissuesTPM*
normal1
germ cell tumor3
non-neoplasia31
primitive neuroectodermal tumor of the CNS7
Developmental Stage
TissuesTPM*
adult3
embryoid body14
blastocyst16
fetus3
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland1
cerebral cortex4.5
kidney1.5
pancreas2.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607718, gene) Synaptotagmin 6; SYT6OMIM


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