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> Protein (NX_Q5TA78)
Protein (NX_Q5TA78)
Protein
Gene SymbolLCE4A to neXtProt (NX_Q5TA78)
DescriptionLate cornified envelope protein 4A
Chromosome1
Location1q21.3 (152680636 ~ 152681967) to Ensembl
Sequene Features : Isoforms 1, Variants 24, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.keratinization .N/A .N/A
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01transcript level
1 24 0
2014-09-19transcript level
1 21 0
2014-05-27transcript level
1 21 0
2014-02-25transcript level
1 21 0
2013-12-09transcript level
1 18 0
2013-11-01transcript level
1 18 0
2013-09-12transcript level
1 18 0
2013-08-17transcript level
1 18 0
2013-07-15transcript level
1 15 0
2013-06-11transcript level
1 15 0
2013-02-12transcript level
1 6 0
2012-12-20transcript level
1 6 0
2012-10-30transcript level
1 7 0
2012-10-07transcript level
1 7 0
2012-08-24transcript level
1 7 0
2012-07-28transcript level
1 7 0
2012-06-08transcript level
1 7 0
2012-05-07transcript level
1 6 0
2012-04-10transcript level
1 6 0
2012-01-13transcript level
1 10 0
2011-12-20transcript level
1 10 0
2011-11-11transcript level
1 10 0
2011-08-23transcript level
1 10 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5TA78-1
2 0 1 9972.9606
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10246358,EBI-740019 PLSCR1  
  .positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
.regulation of Fc receptor mediated stimulatory signaling pathway
.defense response to virus
  + 11 more...
.CD4 receptor binding
.enzyme binding
.phospholipid scramblase activity
  + 5 more...
.extracellular exosome
.membrane raft
.extracellular matrix
  + 7 more...
2 EBI-10246358,EBI-742487 SPRY2  
  .positive regulation of protein serine/threonine kinase activity
.positive regulation of ERK1 and ERK2 cascade
.negative regulation of ERK1 and ERK2 cascade
  + 19 more...
.protein serine/threonine kinase activator activity
.protein serine/threonine kinase inhibitor activity
.protein kinase binding
.ruffle membrane
.microtubule cytoskeleton
.plasma membrane
  + 2 more...
3 EBI-10246358,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
4 EBI-10246358,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
5 EBI-10246358,EBI-740446 OTX1  
  .diencephalon morphogenesis
.positive regulation of transcription from RNA polymerase II promoter
.inner ear morphogenesis
  + 3 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
6 EBI-10246358,EBI-740785 HOXA1  
  .cochlea morphogenesis
.cochlea development
.cellular response to retinoic acid
  + 24 more...
.sequence-specific DNA binding .nucleus
7 EBI-10246358,EBI-750494 SMCP  
  .sperm motility
.penetration of zona pellucida
.N/A .mitochondrial membrane
.mitochondrion
.cytoplasm
8 EBI-10246358,EBI-10176379 KRTAP12-2  
  .N/A .N/A .keratin filament
9 EBI-10246358,EBI-10172150 KRTAP10-5  
  .N/A .identical protein binding .keratin filament
10 EBI-10246358,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
11 EBI-10246358,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
12 EBI-10246358,EBI-10172052 KRTAP10-9  
  .N/A .N/A .keratin filament
13 EBI-10246358,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
14 EBI-10246358,EBI-10173507 ADAMTSL4  
  .cellular protein metabolic process
.post-translational protein modification
.positive regulation of apoptotic process
  + 4 more...
.metalloendopeptidase activity
.protease binding
.endoplasmic reticulum lumen
.interstitial matrix
15 EBI-10246358,EBI-2129175 RNF111  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.positive regulation of protein ubiquitination
  + 9 more...
.ubiquitin protein ligase activity
.SUMO polymer binding
.ligase activity
.zinc ion binding
.protein complex
.cytoplasm
.nucleolus
  + 2 more...
16 EBI-10246358,EBI-724076 MDFI  
  .trophoblast giant cell differentiation
.embryonic skeletal system morphogenesis
.negative regulation of DNA binding
  + 6 more...
.N/A .cytoplasm
.nucleus
17 EBI-10246358,EBI-739863 KRTAP4-12  
  .N/A .N/A .keratin filament
18 EBI-10246358,EBI-10185730 KRTAP9-4  
  .N/A .N/A .keratin filament
19 EBI-10246358,EBI-1044640 KRTAP9-2  
  .N/A .N/A .keratin filament
20 EBI-10246358,EBI-10172511 KRTAP4-2  
  .N/A .N/A .keratin filament
21 EBI-10246358,EBI-751260 KRTAP3-2  
  .N/A .structural molecule activity .keratin filament
22 EBI-10246358,EBI-3918154 RGS17  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.GTPase activator activity .plasma membrane
.cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
connective tissue13
Health State
TissuesTPM*
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
skin4.7
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*612618, gene) Late cornified envelope protein 4a; LCE4AOMIM


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