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> Protein (NX_Q5TCZ1)
Protein (NX_Q5TCZ1)
Protein
Gene SymbolSH3PXD2A to neXtProt (NX_Q5TCZ1)
DescriptionSH3 and PX domain-containing protein 2A
Chromosome10
Location10q24.33 (105348285 ~ 105615301) to Ensembl
Sequene Features : Isoforms 3, Variants 138, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.osteoclast fusion
.superoxide metabolic process
.phosphatidylinositol binding .cell projection
.cell junction
.cytoplasm
.podosome
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 138 16
2014-09-19protein level
3 114 16
2014-05-27protein level
3 114 16
2014-02-25protein level
3 114 16
2013-12-09protein level
3 88 16
2013-11-01protein level
3 85 16
2013-09-12protein level
3 85 15
2013-08-17protein level
3 85 15
2013-07-15protein level
3 58 15
2013-06-11protein level
3 58 15
2013-02-12protein level
3 30 39
2012-12-20protein level
3 30 39
2012-10-30protein level
3 30 39
2012-10-07protein level
3 30 13
2012-08-24protein level
3 25 13
2012-07-28protein level
3 25 13
2012-06-08protein level
3 27 13
2012-05-07protein level
3 27 13
2012-04-10protein level
3 27 13
2012-01-13protein level
3 14 13
2011-12-20protein level
3 14 13
2011-11-11protein level
3 14 13
2011-08-23protein level
3 14 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5TCZ1-1
1 58 2 125212.1812
NX_Q5TCZ1-2
1 49 1 102555.3702
NX_Q5TCZ1-3
0 58 2 121761.2468
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-7014859,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
2 EBI-2483234,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone55
brain49
cervix103
connective tissue40
embryonic tissue46
eye47
heart100
intestine30
kidney28
larynx85
liver24
lung44
lymph node11
mouth75
muscle65
ovary49
pancreas23
parathyroid97
pharynx24
pituitary gland60
placenta60
prostate36
skin61
spleen18
stomach20
testis20
thymus12
trachea38
uterus68
vascular19
Health State
TissuesTPM*
normal47
chondrosarcoma48
colorectal tumor17
gastrointestinal tumor16
germ cell tumor22
glioma27
head and neck tumor44
kidney tumor58
leukemia10
liver tumor20
lung tumor19
non-neoplasia20
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS31
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult45
embryoid body85
blastocyst48
fetus68
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.7
adrenal gland6.4
appendix11.8
bone marrow1.3
cerebral cortex10.3
colon14.8
duodenum5.4
esophagus20.1
gallbladder20.1
heart muscle10.1
kidney3.9
liver3.4
lung10.5
lymph node4.9
ovary21.2
pancreas3.2
placenta17.2
prostate9.5
salivary gland5.8
skin25.8
small intestine8.2
spleen9.6
stomach7
testis4.3
thyroid gland3.3
urinary bladder15.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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