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> Protein (NX_Q5U5Q3)
Protein (NX_Q5U5Q3)
Protein
Gene SymbolMEX3C to neXtProt (NX_Q5U5Q3)
DescriptionRNA-binding E3 ubiquitin-protein ligase MEX3C
Chromosome18
Location18q21.2 (48700920 ~ 48744674) to Ensembl
Sequene Features : Isoforms 1, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.energy homeostasis
.regulation of fat cell differentiation
.chondrocyte hypertrophy
.poly(A) RNA binding
.ligase activity
.zinc ion binding
.cytoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 49 1
2014-09-19protein level
1 42 1
2014-05-27protein level
1 42 1
2014-02-25protein level
1 41 1
2013-12-09protein level
1 34 1
2013-11-01protein level
1 32 1
2013-09-12protein level
1 32 1
2013-08-17protein level
1 32 1
2013-07-15protein level
1 22 0
2013-06-11protein level
1 22 0
2013-02-12protein level
1 6 1
2012-12-20protein level
1 5 1
2012-10-30protein level
1 10 1
2012-10-07protein level
1 10 1
2012-08-24protein level
1 7 1
2012-07-28protein level
1 7 1
2012-06-08protein level
1 10 1
2012-05-07protein level
1 10 1
2012-04-10protein level
1 10 1
2012-01-13protein level
1 11 1
2011-12-20protein level
1 11 1
2011-11-11protein level
1 11 1
2011-08-23protein level
1 11 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5U5Q3-1
20 0 3 69322.9885
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2864451,EBI-302474 USP7  
  .regulation of proteasomal protein catabolic process
.regulation of sequence-specific DNA binding transcription factor activity
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 7 more...
.ubiquitin protein ligase binding
.transcription factor binding
.protein C-terminus binding
  + 3 more...
.PML body
.nuclear body
.cytosol
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
blood8
bone marrow102
brain12
cervix41
connective tissue6
embryonic tissue51
esophagus49
eye14
heart44
intestine17
kidney66
liver14
lung65
lymph22
lymph node111
mammary gland13
mouth45
muscle9
ovary59
pancreas18
parathyroid145
prostate15
salivary gland49
skin23
testis62
thymus50
thyroid236
uterus47
vascular38
Health State
TissuesTPM*
normal29
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor28
colorectal tumor26
esophageal tumor57
germ cell tumor34
glioma27
head and neck tumor104
kidney tumor72
leukemia105
liver tumor10
lung tumor29
lymphoma41
non-neoplasia10
ovarian tumor78
prostate cancer9
retinoblastoma21
skin tumor39
soft tissue/muscle tissue tumor39
uterine tumor66
Developmental Stage
TissuesTPM*
adult22
embryoid body42
blastocyst65
fetus46
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16
adrenal gland15.1
appendix18.2
bone marrow30.7
cerebral cortex15.1
colon15.1
duodenum11.5
esophagus16.7
gallbladder21.8
heart muscle10
kidney11.3
liver8.7
lung14.2
lymph node23.8
ovary22.6
pancreas6.9
placenta15.7
prostate12
salivary gland7.8
skin9
small intestine12.8
spleen21.8
stomach13.3
testis107.2
thyroid gland17.2
urinary bladder23.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*611005, gene) Mex3, c. elegans, homolog of, c; MEX3COMIM


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