Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_Q5VTR2)
Protein (NX_Q5VTR2)
Protein
Gene SymbolRNF20 to neXtProt (NX_Q5VTR2)
DescriptionE3 ubiquitin-protein ligase BRE1A
Chromosome9
Location9q31.1 (104296133 ~ 104325622) to Ensembl
Sequene Features : Isoforms 1, Variants 112, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.positive regulation of transcription, DNA-templated
  + 7 more...
.histone binding
.ubiquitin protein ligase binding
.ligase activity
  + 6 more...
.HULC complex
.nucleolus
.nucleoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 112 8
2014-09-19protein level
1 88 8
2014-05-27protein level
1 88 9
2014-02-25protein level
1 87 9
2013-12-09protein level
1 76 9
2013-11-01protein level
1 73 5
2013-09-12protein level
1 73 5
2013-08-17protein level
1 73 5
2013-07-15protein level
1 44 5
2013-06-11protein level
1 44 5
2013-02-12protein level
1 17 8
2012-12-20protein level
1 17 8
2012-10-30protein level
1 23 8
2012-10-07protein level
1 23 8
2012-08-24protein level
1 20 8
2012-07-28protein level
1 20 8
2012-06-08protein level
1 29 8
2012-05-07protein level
1 18 8
2012-04-10protein level
1 18 8
2012-01-13protein level
1 13 8
2011-12-20protein level
1 13 8
2011-11-11protein level
1 13 8
2011-08-23protein level
1 13 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5VTR2-1
42 0 2 113591.9717
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2372238,EBI-744408 RNF40  
  .positive regulation of histone H2B ubiquitination
.negative regulation of mRNA polyadenylation
.histone H2B ubiquitination
  + 2 more...
.protein homodimerization activity
.ubiquitin protein ligase binding
.ligase activity
  + 3 more...
.neuron projection
.HULC complex
.membrane
  + 3 more...
2 EBI-2372238,EBI-1180783 CHEK2  
  .replicative senescence
.mitotic spindle assembly
.signal transduction involved in intra-S DNA damage checkpoint
  + 18 more...
.metal ion binding
.protein homodimerization activity
.identical protein binding
  + 4 more...
.PML body
.Golgi apparatus
.nucleoplasm
3 EBI-2372238,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
4 EBI-2372238,EBI-348546 UBE2E1  
  .protein K48-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin conjugating enzyme activity
.ISG15 transferase activity
.ligase activity
  + 2 more...
.cytosol
.nucleoplasm
.nucleus
.ubiquitin ligase complex
5 EBI-2372238,EBI-739895 USHBP1  
  .N/A .PDZ domain binding .N/A
6 EBI-2372238,EBI-594661 COPS5  
  .exosomal secretion
.regulation of IRE1-mediated unfolded protein response
.regulation of cell cycle
  + 8 more...
.metal ion binding
.metallopeptidase activity
.ubiquitin-specific protease activity
  + 2 more...
.perinuclear region of cytoplasm
.cell junction
.COP9 signalosome
  + 5 more...
7 EBI-2372238,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
bladder167
bone55
bone marrow20
brain50
connective tissue40
embryonic tissue23
esophagus49
eye43
heart33
intestine25
kidney42
liver24
lung26
lymph22
mammary gland52
mouth105
muscle65
nerve64
ovary19
pancreas32
pharynx147
placenta14
prostate42
salivary gland49
skin47
spleen18
stomach20
testis66
trachea77
uterus64
vascular38
Health State
TissuesTPM*
normal37
adrenal tumor158
breast (mammary gland) tumor32
chondrosarcoma48
colorectal tumor8
esophageal tumor57
gastrointestinal tumor8
germ cell tumor72
glioma27
head and neck tumor52
kidney tumor43
leukemia10
liver tumor10
lung tumor9
lymphoma13
non-neoplasia31
ovarian tumor26
pancreatic tumor19
primitive neuroectodermal tumor of the CNS39
prostate cancer57
skin tumor71
soft tissue/muscle tissue tumor39
uterine tumor66
Developmental Stage
TissuesTPM*
adult31
embryoid body57
fetus39
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.5
adrenal gland18.3
appendix15.9
bone marrow8.2
cerebral cortex24.7
colon17.2
duodenum10.2
esophagus20.5
gallbladder16.9
heart muscle22.3
kidney19.8
liver9.9
lung14.8
lymph node17.8
ovary22
pancreas8.2
placenta14.2
prostate20.1
salivary gland12.1
skin15.4
small intestine10.8
spleen16.7
stomach14.5
testis36.5
thyroid gland24.6
urinary bladder21.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaHigh
ovaryHigh
pancreasMedium
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*607699, gene) Ring finger protein 20; RNF20OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center