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> Protein (NX_Q5VU43)
Protein (NX_Q5VU43)
Protein
Gene SymbolPDE4DIP to neXtProt (NX_Q5VU43)
DescriptionMyomegalin
Chromosome1
Location1q21.1 (144836157 ~ 145076186) to Ensembl
Sequene Features : Isoforms 11, Variants 564, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular protein complex assembly .enzyme binding .myofibril
.centrosome
.Golgi apparatus
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
11 564 4
2014-09-19protein level
11 440 4
2014-05-27protein level
11 440 5
2014-02-25protein level
11 439 5
2013-12-09protein level
11 387 5
2013-11-01protein level
11 376 5
2013-09-12protein level
11 376 5
2013-08-17protein level
11 376 5
2013-07-15protein level
11 312 4
2013-06-11protein level
11 312 4
2013-02-12protein level
11 181 6
2012-12-20protein level
11 184 6
2012-10-30protein level
11 183 6
2012-10-07protein level
11 183 1
2012-08-24protein level
11 157 1
2012-07-28protein level
11 156 1
2012-06-08protein level
11 43 1
2012-05-07protein level
11 43 1
2012-04-10protein level
11 43 1
2012-01-13protein level
11 43 1
2011-12-20protein level
11 43 1
2011-11-11protein level
11 43 1
2011-08-23protein level
12 43 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_Q5VU43-1
0 114 0 264916.7709
NX_Q5VU43-10
0 7 0 20785.5417
NX_Q5VU43-11
0 7 0 20672.458
NX_Q5VU43-12
0 11 0 28489.3163
NX_Q5VU43-2
17 37 0 128383.9801
NX_Q5VU43-3
2 108 0 253889.7598
NX_Q5VU43-4
2 113 0 267012.7483
NX_Q5VU43-6
0 46 0 112162.499
NX_Q5VU43-7
1 45 0 114083.3726
NX_Q5VU43-8
0 14 0 36098.775
NX_Q5VU43-9
0 14 0 36211.8587
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1105124,EBI-373498 MIF4GD  
  .regulation of translation .protein C-terminus binding
.RNA binding
.cytoplasm
.nucleolus
2 EBI-1105124,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-1105124,EBI-747693 NAA10  
  .N-terminal peptidyl-glutamic acid acetylation
.N-terminal peptidyl-serine acetylation
.internal protein amino acid acetylation
  + 2 more...
.peptide-glutamate-N-acetyltransferase activity
.peptide-serine-N-acetyltransferase activity
.N-acetyltransferase activity
.NatA complex
.cytosolic ribosome
.membrane
  + 4 more...
4 EBI-1105124,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
5 EBI-1105124,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
6 EBI-1105124,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
7 EBI-1105124,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
8 EBI-1105124,EBI-10217913 RTP5  
  .N/A .N/A .integral component of membrane
9 EBI-1105124,EBI-1004115 MAPRE1  
  .positive regulation of microtubule plus-end binding
.cell division
.protein localization to microtubule
  + 7 more...
.microtubule plus-end binding
.poly(A) RNA binding
.protein C-terminus binding
.microtubule plus-end
.cell projection membrane
.cortical microtubule cytoskeleton
  + 6 more...
10 EBI-1105124,EBI-3920053 ZSCAN26  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.nucleic acid binding
.nucleus
11 EBI-1105124,EBI-719941 FAM161A  
  .response to stimulus
.cilium assembly
.visual perception
.N/A .ciliary basal body
.photoreceptor connecting cilium
.centrosome
.cytoplasm
12 EBI-1105124,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
13 EBI-1105124,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
14 EBI-1105124,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
15 EBI-1105124,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
16 EBI-1105124,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
17 EBI-1105124,EBI-726510 LENG1  
  .N/A .N/A .N/A
18 EBI-1105124,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
19 EBI-1105124,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
20 EBI-1105124,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
21 EBI-1105124,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
22 EBI-1105124,EBI-347633 ZNF408  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.identical protein binding
.DNA binding
.nucleus
23 EBI-1105124,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
24 EBI-1105124,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
25 EBI-1105124,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
26 EBI-1105124,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
blood57
bone195
bone marrow123
brain1
cervix61
connective tissue154
ear62
embryonic tissue84
esophagus99
eye9
heart502
intestine43
kidney66
larynx213
liver77
lung209
lymph45
lymph node33
mammary gland79
mouth317
muscle855
nerve321
ovary9
pancreas131
parathyroid97
pharynx24
pituitary gland181
placenta197
prostate31
salivary gland345
skin4
spleen37
stomach52
testis52
thymus25
thyroid128
trachea173
uterus38
vascular38
Health State
TissuesTPM*
normal2
breast (mammary gland) tumor96
cervical tumor86
chondrosarcoma132
colorectal tumor35
esophageal tumor115
gastrointestinal tumor33
germ cell tumor87
glioma9
head and neck tumor127
kidney tumor14
leukemia10
non-neoplasia10
pancreatic tumor9
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult142
embryoid body57
blastocyst65
neonate64
fetus5
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue57.3
adrenal gland38
appendix41.7
bone marrow14.7
cerebral cortex172.5
colon37.5
duodenum37
esophagus153.3
gallbladder46.2
heart muscle1832.2
kidney49.6
liver54
lung61
lymph node46.3
ovary21.6
pancreas21.2
placenta158.7
prostate88.4
salivary gland20.4
skin48.1
small intestine45.1
spleen31.8
stomach32.9
testis21.3
thyroid gland20.6
urinary bladder49.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*608117, gene) Phosphodiesterase 4d-interacting protein; PDE4DIPOMIM
2Myeloproliferative disorderCGP


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